{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:36:58Z","timestamp":1788871018341,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":2647,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003180","name":"Academic Medical Center","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003180","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Wellcome Trust of Great Britain","award":["086532\/Z\/08\/Z"],"award-info":[{"award-number":["086532\/Z\/08\/Z"]}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organization for Health Research and Development","doi-asserted-by":"crossref","award":["90700424"],"award-info":[{"award-number":["90700424"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Netherlands Organization for Scientific Research","award":["91610008"],"award-info":[{"award-number":["91610008"]}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1111\/jth.12776","type":"journal-article","created":{"date-parts":[[2014,11,5]],"date-time":"2014-11-05T01:56:19Z","timestamp":1415152579000},"page":"41-46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Diabetes\u2010independent increase of factor\u00a0VII\u2010activating protease activation in patients with Gram\u2010negative sepsis (melioidosis)"],"prefix":"10.1016","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6224-7947","authenticated-orcid":false,"given":"H.K.","family":"de Jong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.C.K.W.","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Bulder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Stephan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.J.","family":"Wiersinga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.S.","family":"Zeerleder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/jth.12776_bb0010","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1097\/00003246-199907000-00002","article-title":"Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction","volume":"27","author":"Hotchkiss","year":"1999","journal-title":"Crit Care Med"},{"key":"10.1111\/jth.12776_bb0015","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1097\/01.CCM.0000074719.40109.95","article-title":"Elevated nucleosome levels in systemic inflammation and sepsis","volume":"31","author":"Zeerleder","year":"2003","journal-title":"Crit Care Med"},{"key":"10.1111\/jth.12776_bb0020","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1097\/CCM.0b013e318265695f","article-title":"Circulating nucleosomes and severity of illness in children suffering from meningococcal sepsis treated with protein\u00a0C","volume":"40","author":"Zeerleder","year":"2012","journal-title":"Crit Care Med"},{"key":"10.1111\/jth.12776_bb0025","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1128\/CMR.18.2.383-416.2005","article-title":"Melioidosis: epidemiology, pathophysiology, and management","volume":"18","author":"Cheng","year":"2005","journal-title":"Clin Microbiol Rev"},{"key":"10.1111\/jth.12776_bb0030","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1086\/315642","article-title":"Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram\u2010negative bacteria","volume":"182","author":"Lauw","year":"2000","journal-title":"J\u00a0Infect Dis"},{"key":"10.1111\/jth.12776_bb0035","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1128\/IAI.00080-07","article-title":"Endogenous interleukin\u201018 improves the early antimicrobial host response in severe melioidosis","volume":"75","author":"Wiersinga","year":"2007","journal-title":"Infect Immun"},{"key":"10.1111\/jth.12776_bb0040","doi-asserted-by":"crossref","first-page":"e1002452","DOI":"10.1371\/journal.ppat.1002452","article-title":"Inflammasome\u2010dependent pyroptosis and IL\u201018 protect against Burkholderia pseudomallei lung infection while IL\u20101beta is deleterious","volume":"7","author":"Ceballos\u2010Olvera","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1111\/jth.12776_bb0045","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1056\/NEJMra1204699","article-title":"Melioidosis","volume":"367","author":"Wiersinga","year":"2012","journal-title":"N Engl J\u00a0Med"},{"key":"10.1111\/jth.12776_bb0050","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/cid\/ciq192","article-title":"Glyburide is anti\u2010inflammatory and associated with reduced mortality in melioidosis","volume":"52","author":"Koh","year":"2011","journal-title":"Clin Infect Dis"},{"key":"10.1111\/jth.12776_bb0055","doi-asserted-by":"crossref","first-page":"R110","DOI":"10.1186\/cc10131","article-title":"Activation of factor\u00a0VII\u2010activating protease in human inflammation: a sensor for cell death","volume":"15","author":"Stephan","year":"2011","journal-title":"Crit Care"},{"key":"10.1111\/jth.12776_bb0060","doi-asserted-by":"crossref","first-page":"5382","DOI":"10.1016\/j.febslet.2007.10.037","article-title":"A plasma nucleosome releasing factor (NRF) with serine protease activity is instrumental in removal of nucleosomes from secondary necrotic cells","volume":"581","author":"Zeerleder","year":"2007","journal-title":"FEBS Lett"},{"key":"10.1111\/jth.12776_bb0065","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1096\/fj.08-110429","article-title":"Nucleosome\u2010releasing factor: a new role for factor\u00a0VII\u2010activating protease (FSAP)","volume":"22","author":"Zeerleder","year":"2008","journal-title":"FASEB J"},{"key":"10.1111\/jth.12776_bb0070","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/art.38265","article-title":"Cooperation of factor\u00a0VII\u2010activating protease and serum DNase\u00a0I in the release of nucleosomes from necrotic cells","volume":"66","author":"Stephan","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.1111\/jth.12776_bb0075","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.bbrc.2011.05.030","article-title":"Extracellular histone induces plasma hyaluronan\u2010binding protein (factor\u00a0VII activating protease) activation in\u00a0vivo","volume":"409","author":"Yamamichi","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/jth.12776_bb0080","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1111\/j.1538-7836.2012.04712.x","article-title":"Tissue factor pathway inhibitor is an inhibitor of factor\u00a0VII\u2010activating protease","volume":"10","author":"Stephan","year":"2012","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1111\/jth.12776_bb0085","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1538-7836.2007.02796.x","article-title":"Activation of coagulation with concurrent impairment of anticoagulant mechanisms correlates with a poor outcome in severe melioidosis","volume":"6","author":"Wiersinga","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.12776_bb0090","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1086\/520223","article-title":"Risk factors for melioidosis and bacteremic melioidosis","volume":"29","author":"Suputtamongkol","year":"1999","journal-title":"Clin Infect Dis"},{"key":"10.1111\/jth.12776_bb0095","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s10096-011-1337-4","article-title":"The impact of diabetes on the pathogenesis of sepsis","volume":"31","author":"Koh","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1111\/jth.12776_bb0100","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1160\/TH11-07-0504","article-title":"Diabetes does not influence activation of coagulation, fibrinolysis or anticoagulant pathways in Gram\u2010negative sepsis (melioidosis)","volume":"106","author":"Koh","year":"2011","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.12776_bb0105","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1161\/ATVBAHA.112.300498","article-title":"Circulating nucleosomes and neutrophil activation as risk factors for deep vein thrombosis","volume":"33","author":"van Montfoort","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/jth.12776_bb0110","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1136\/ard.62.1.10","article-title":"Time between onset of apoptosis and release of nucleosomes from apoptotic cells: putative implications for systemic lupus erythematosus","volume":"62","author":"van Nieuwenhuijze","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"10.1111\/jth.12776_bb0115","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/nm.2053","article-title":"Extracellular histones are major mediators of death in sepsis","volume":"15","author":"Xu","year":"2009","journal-title":"Nat Med"},{"key":"10.1111\/jth.12776_bb0120","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/jth.12094","article-title":"Endogenous protein\u00a0C has a protective role during Gram\u2010negative pneumosepsis (melioidosis)","volume":"11","author":"Kager","year":"2013","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.12776_bb0125","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1128\/IAI.73.4.1907-1916.2005","article-title":"Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells","volume":"73","author":"Fink","year":"2005","journal-title":"Infect Immun"},{"key":"10.1111\/jth.12776_bb0130","doi-asserted-by":"crossref","first-page":"6335","DOI":"10.1182\/blood-2012-01-405183","article-title":"Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice","volume":"119","author":"Thomas","year":"2012","journal-title":"Blood"},{"key":"10.1111\/jth.12776_bb0135","doi-asserted-by":"crossref","DOI":"10.1186\/s40635-014-0021-2","article-title":"Neutrophil extracellular traps in the host defense against sepsis induced by Burkholderia pseudomallei (melioidosis)","volume":"2","author":"De Jong","year":"2014","journal-title":"Intensive Care Med Exp"},{"key":"10.1111\/jth.12776_bb0140","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nm.2184","article-title":"Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases","volume":"16","author":"Massberg","year":"2010","journal-title":"Nat Med"},{"key":"10.1111\/jth.12776_bb0145","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.156.3.1151","article-title":"Blood clearance kinetics and liver uptake of mononucleosomes in mice","volume":"156","author":"Gauthier","year":"1996","journal-title":"J Immunol"},{"key":"10.1111\/jth.12776_bb0150","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1128\/IAI.00503-08","article-title":"Human polymorphonuclear neutrophil responses to Burkholderia pseudomallei in healthy and diabetic subjects","volume":"77","author":"Chanchamroen","year":"2009","journal-title":"Infect Immun"},{"key":"10.1111\/jth.12776_bb0155","doi-asserted-by":"crossref","first-page":"3921","DOI":"10.1128\/IAI.00806-12","article-title":"Neutrophil extracellular traps exhibit antibacterial activity against Burkholderia pseudomallei and are influenced by bacterial and host factors","volume":"80","author":"Riyapa","year":"2012","journal-title":"Infect Immun"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.12776","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.12776","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jth.12776","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622034171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622034171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.12776","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:09:55Z","timestamp":1761534595000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622034171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S1538783622034171"],"URL":"https:\/\/doi.org\/10.1111\/jth.12776","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diabetes\u2010independent increase of factor\u00a0VII\u2010activating protease activation in patients with Gram\u2010negative sepsis (melioidosis)","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/jth.12776","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Journal of Thrombosis and Haemostasis. Published by ELSEVIER INC. on behalf of International Society on Thrombosis and Haemostasis","name":"copyright","label":"Copyright"}]}}