{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:28:40Z","timestamp":1789176520998,"version":"build-2803163510"},"reference-count":25,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":2777,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Science Foundation Ireland Principal Investigator","award":["11\/PI\/1066"],"award-info":[{"award-number":["11\/PI\/1066"]}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1111\/jth.12875","type":"journal-article","created":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T10:17:55Z","timestamp":1424168275000},"page":"821-826","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["von Willebrand factor arginine 1205 substitution results in accelerated macrophage\u2010dependent clearance in vivo"],"prefix":"10.1016","volume":"13","author":[{"given":"O.","family":"Rawley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"O'Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Chion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Keyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lavin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"van Rooijen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.M.","family":"Brophy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Fallon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.J.S.","family":"Preston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.S.","family":"O'Donnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 1","key":"10.1111\/jth.12875_bb0010","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/jth.12226","article-title":"Clearance of von Willebrand factor","volume":"11","author":"Casari","year":"2013","journal-title":"J Thromb Haemost"},{"issue":"Suppl 1","key":"10.1111\/jth.12875_bb0015","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1538-7836.2009.03381.x","article-title":"Reduced von Willebrand factor survival in von Willebrand disease: pathophysiologic and clinical relevance","volume":"7","author":"Castaman","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.12875_bb0020","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1046\/j.1538-7836.2003.00359.x","article-title":"Increased clearance of von Willebrand factor antigen post\u2010DDAVP in Type 1 von Willebrand disease: is it a potential pathogenic process?","volume":"1","author":"Brown","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.12875_bb0025","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1160\/TH07-10-0629","article-title":"Clearance of von Willebrand factor","volume":"99","author":"Denis","year":"2008","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.12875_bb0030","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1111\/j.1538-7836.2005.01571.x","article-title":"Cysteine\u2010mutations in von Willebrand factor associated with increased clearance","volume":"3","author":"Schooten","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.12875_bb0035","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1182\/blood-2006-04-015065","article-title":"Assay of the von Willebrand factor (VWF) propeptide to identify patients with type 1 von Willebrand disease with decreased VWF survival","volume":"108","author":"Haberichter","year":"2006","journal-title":"Blood"},{"key":"10.1111\/jth.12875_bb0040","doi-asserted-by":"crossref","first-page":"4979","DOI":"10.1182\/blood-2007-09-110940","article-title":"Identification of type 1 von Willebrand disease patients with reduced von Willebrand factor survival by assay of the VWF propeptide in the European study: molecular and clinical markers for the diagnosis and management of type 1 VWD (MCMDM\u20101VWD)","volume":"111","author":"Haberichter","year":"2008","journal-title":"Blood"},{"key":"10.1111\/jth.12875_bb0045","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.3324\/haematol.2009.019927","article-title":"Reduced survival of type 2B von Willebrand factor, irrespective of large multimer representation or thrombocytopenia","volume":"95","author":"Casonato","year":"2010","journal-title":"Haematologica"},{"key":"10.1111\/jth.12875_bb0050","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1182\/blood-2012-09-455089","article-title":"VWF propeptide and ratios between VWF, VWF propeptide, and FVIII in the characterization of type 1 von Willebrand disease","volume":"121","author":"Eikenboom","year":"2013","journal-title":"Blood"},{"key":"10.1111\/jth.12875_bb0055","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1182\/blood.V99.1.180","article-title":"Reduced von Willebrand factor survival in type Vicenza von Willebrand disease","volume":"99","author":"Casonato","year":"2002","journal-title":"Blood"},{"key":"10.1111\/jth.12875_bb0060","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1182\/blood.V71.1.65.65","article-title":"von Willebrand disease \u201cVicenza\u201d with larger\u2010than\u2010normal (supranormal) von Willebrand factor multimers","volume":"71","author":"Mannucci","year":"1988","journal-title":"Blood"},{"key":"10.1111\/jth.12875_bb0065","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1111\/j.1538-7836.2010.03753.x","article-title":"Accelerated clearance alone explains ultra\u2010large multimers in von Willebrand disease Vicenza","volume":"8","author":"Gezsi","year":"2010","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.12875_bb0070","doi-asserted-by":"crossref","first-page":"12102","DOI":"10.1074\/jbc.M310436200","article-title":"An experimental model to study the in vivo survival of von Willebrand factor. Basic aspects and application to the R1205H mutation","volume":"279","author":"Lenting","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.12875_bb0075","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1182\/blood-2010-08-303727","article-title":"Pathologic mechanisms of type 1 VWD mutations R1205H and Y1584C through in vitro and in vivo mouse models","volume":"117","author":"Pruss","year":"2011","journal-title":"Blood"},{"key":"10.1111\/jth.12875_bb0080","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1182\/blood-2008-01-133181","article-title":"Macrophages contribute to the cellular uptake of von Willebrand factor and factor VIII in vivo","volume":"112","author":"van Schooten","year":"2008","journal-title":"Blood"},{"key":"10.1111\/jth.12875_bb0085","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1182\/blood-2011-08-373605","article-title":"Macrophage LRP1 contributes to the clearance of von Willebrand factor","volume":"119","author":"Rastegarlari","year":"2012","journal-title":"Blood"},{"key":"10.1111\/jth.12875_bb0090","doi-asserted-by":"crossref","first-page":"10042","DOI":"10.1073\/pnas.142005099","article-title":"Sialyltransferase ST3Gal\u2010IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands","volume":"99","author":"Ellies","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1111\/jth.12875_bb0095","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1182\/blood-2007-11-122945","article-title":"A shorter von Willebrand factor survival in O blood group subjects explains how ABO determinants influence plasma von Willebrand factor","volume":"111","author":"Gallinaro","year":"2008","journal-title":"Blood"},{"key":"10.1111\/jth.12875_bb0100","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nm1760","article-title":"The Ashwell receptor mitigates the lethal coagulopathy of sepsis","volume":"14","author":"Grewal","year":"2008","journal-title":"Nat Med"},{"key":"10.1111\/jth.12875_bb0105","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1182\/blood-2007-06-095042","article-title":"N\u2010linked glycosylation of VWF modulates its interaction with ADAMTS13","volume":"111","author":"McKinnon","year":"2008","journal-title":"Blood"},{"key":"10.1111\/jth.12875_bb0110","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1182\/blood-2012-02-410050","article-title":"O\u2010linked glycosylation of von Willebrand factor modulates the interaction with platelet receptor glycoprotein Ib under static and shear stress conditions","volume":"120","author":"Nowak","year":"2012","journal-title":"Blood"},{"key":"10.1111\/jth.12875_bb0115","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1182\/blood-2009-09-241547","article-title":"Expression of terminal alpha2\u20106\u2010linked sialic acid on von Willebrand factor specifically enhances proteolysis by ADAMTS13","volume":"115","author":"McGrath","year":"2010","journal-title":"Blood"},{"key":"10.1111\/jth.12875_bb0120","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/jlb.45.2.97","article-title":"Macrophage subset repopulation in the spleen: differential kinetics after liposome\u2010mediated elimination","volume":"45","author":"van Rooijen","year":"1989","journal-title":"J Leukoc Biol"},{"key":"10.1111\/jth.12875_bb0125","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1160\/TH07-09-0565","article-title":"Survival of von Willebrand factor released following DDAVP in a type 1 von Willebrand disease cohort: influence of glycosylation, proteolysis and gene mutations","volume":"99","author":"Millar","year":"2008","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.12875_bb0130","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1074\/jbc.M513314200","article-title":"Shielding of the A1 domain by the D'D3 domains of von Willebrand factor modulates its interaction with platelet glycoprotein Ib\u2010IX\u2010V","volume":"281","author":"Ulrichts","year":"2006","journal-title":"J Biol Chem"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.12875","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.12875","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622089784?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622089784?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/jth.12875\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:10:27Z","timestamp":1761534627000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622089784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S1538783622089784"],"URL":"https:\/\/doi.org\/10.1111\/jth.12875","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"von Willebrand factor arginine 1205 substitution results in accelerated macrophage\u2010dependent clearance in vivo","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/jth.12875","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}