{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:11:56Z","timestamp":1779235916543,"version":"3.51.4"},"reference-count":21,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":2282,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1111\/jth.13171","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T09:43:10Z","timestamp":1444902190000},"page":"137-142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Discovery and characterization of an antibody directed against exosite I of thrombin"],"prefix":"10.1016","volume":"14","author":[{"given":"T.P.","family":"Baglin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Langdown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Frasson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Huntington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1111\/jth.13171_bb0010","series-title":"Recent Advances in Thrombosis and Hemostasis 2008","first-page":"80","article-title":"Structural insights into the life history of thrombin","author":"Huntington","year":"2008"},{"key":"10.1111\/jth.13171_bb0015","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.tips.2003.09.002","article-title":"Targeting thrombin\u2013rational drug design from natural mechanisms","volume":"24","author":"Huntington","year":"2003","journal-title":"Trends Pharmacol Sci"},{"key":"10.1111\/jth.13171_bb0020","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1182\/blood-2005-04-1710","article-title":"Directing thrombin","volume":"106","author":"Lane","year":"2005","journal-title":"Blood"},{"key":"10.1111\/jth.13171_bb0025","doi-asserted-by":"crossref","DOI":"10.1002\/clc.22434","article-title":"Non\u2010vitamin K antagonist oral anticoagulant use in patients with atrial fibrillation and associated intracranial hemorrhage: a focused review","author":"Arbit","year":"2015","journal-title":"Clin Cardiol"},{"key":"10.1111\/jth.13171_bb0030","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1365-2141.1982.tb01966.x","article-title":"An acquired coagulation inhibitor to factor II","volume":"50","author":"Scully","year":"1982","journal-title":"Br J Haematol"},{"key":"10.1111\/jth.13171_bb0035","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/00000658-200101000-00014","article-title":"Immunologic impact and clinical outcomes after surgical exposure to bovine thrombin","volume":"233","author":"Ortel","year":"2001","journal-title":"Ann Surg"},{"key":"10.1111\/jth.13171_bb0040","doi-asserted-by":"crossref","first-page":"14087","DOI":"10.1073\/pnas.1005255107","article-title":"NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation","volume":"107","author":"Lechtenberg","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/jth.13171_bb0045","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ab.2008.03.035","article-title":"Determining kinetics and affinities of protein interactions using a parallel real\u2010time label\u2010free biosensor, the Octet","volume":"377","author":"Abdiche","year":"2008","journal-title":"Anal Biochem"},{"key":"10.1111\/jth.13171_bb0050","series-title":"Evolving Methods for Macromolecular Crystallography","first-page":"41","article-title":"Processing diffraction data with mosflm","author":"Leslie","year":"2007"},{"key":"10.1111\/jth.13171_bb0055","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1107\/S090744491003982X","article-title":"An introduction to data reduction: space\u2010group determination, scaling and intensity statistics","volume":"67","author":"Evans","year":"2011","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"10.1111\/jth.13171_bb0060","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1107\/S0907444905001617","article-title":"Likelihood\u2010enhanced fast translation functions","volume":"61","author":"McCoy","year":"2005","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"10.1111\/jth.13171_bb0065","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1182\/blood-2006-03-011031","article-title":"Synthetic anti\u2010BR3 antibodies that mimic BAFF binding and target both human and murine B cells","volume":"108","author":"Lee","year":"2006","journal-title":"Blood"},{"key":"10.1111\/jth.13171_bb0070","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1002\/j.1460-2075.1989.tb08511.x","article-title":"The refined 1.9 A crystal structure of human alpha\u2010thrombin: interaction with D\u2010Phe\u2010Pro\u2010Arg chloromethylketone and significance of the Tyr\u2010Pro\u2010Pro\u2010Trp insertion segment","volume":"8","author":"Bode","year":"1989","journal-title":"EMBO J"},{"key":"10.1111\/jth.13171_bb0075","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1107\/S0907444996012255","article-title":"Refinement of macromolecular structures by the maximum\u2010likelihood method","volume":"53","author":"Murshudov","year":"1997","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"10.1111\/jth.13171_bb0080","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1159\/000071636","article-title":"Calibrated automated thrombin generation measurement in clotting plasma","volume":"33","author":"Hemker","year":"2003","journal-title":"Pathophysiol Haemost Thromb"},{"key":"10.1111\/jth.13171_bb0085","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1016\/S0021-9258(17)41920-X","article-title":"Activation\u2010induced exposure of the thrombin anion\u2010binding exosite. Interactions of recombinant mutant prothrombins with thrombomodulin and a thrombin exosite\u2010specific antibody","volume":"269","author":"Wu","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.13171_bb0090","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1111\/j.1538-7836.2005.01363.x","article-title":"Molecular recognition mechanisms of thrombin","volume":"3","author":"Huntington","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.13171_bb0095","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-3-7091-0693-8_5","article-title":"Developing a model of chronic subdural hematoma","volume":"111","author":"Tang","year":"2011","journal-title":"Acta Neurochir Suppl"},{"key":"10.1111\/jth.13171_bb0100","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.clineuro.2012.10.008","article-title":"Anticoagulation therapy a risk factor for the development of chronic subdural hematoma","volume":"115","author":"Aspegren","year":"2013","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1111\/jth.13171_bb0105","doi-asserted-by":"crossref","first-page":"e68732","DOI":"10.1371\/journal.pone.0068732","article-title":"Antiplatelet\/anticoagulant agents and chronic subdural hematoma in the elderly","volume":"8","author":"De Bonis","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1111\/jth.13171_bb0110","doi-asserted-by":"crossref","first-page":"3588","DOI":"10.1021\/bi0525369","article-title":"Structural basis for sequential cleavage of fibrinopeptides upon fibrin assembly","volume":"45","author":"Pechik","year":"2006","journal-title":"Biochemistry"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.13171","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.13171","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622049091?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622049091?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/jth.13171\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:13:43Z","timestamp":1761534823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622049091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S1538783622049091"],"URL":"https:\/\/doi.org\/10.1111\/jth.13171","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery and characterization of an antibody directed against exosite I of thrombin","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/jth.13171","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Journal of Thrombosis and Haemostasis. Published by ELSEVIER INC. on behalf of International Society on Thrombosis and Haemostasis","name":"copyright","label":"Copyright"}]}}