{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:47:50Z","timestamp":1790754470133,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":2163,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["13\/CDA\/2119"],"award-info":[{"award-number":["13\/CDA\/2119"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1111\/jth.13501","type":"journal-article","created":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T11:08:03Z","timestamp":1473332883000},"page":"2536-2547","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Inhibition of major integrin \u03b1V\u03b23 reduces Staphylococcus aureus attachment to sheared human endothelial cells"],"prefix":"10.1016","volume":"14","author":[{"given":"C.J.","family":"McDonnell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.D.","family":"Garciarena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.L.","family":"Watkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.M.","family":"McHale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"McLoughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Claes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Verhamme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.M.","family":"Cummins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.W.","family":"Kerrigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/jth.13501_bb0010","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis\u20103)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1111\/jth.13501_bb0015","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S1473-3099(15)70112-X","article-title":"Sepsis: a roadmap for future research","volume":"15","author":"Cohen","year":"2015","journal-title":"Lancet Infect Dis"},{"key":"10.1111\/jth.13501_bb0020","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.1182\/blood-2002-06-1887","article-title":"The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome","volume":"101","author":"Aird","year":"2003","journal-title":"Blood"},{"key":"10.1111\/jth.13501_bb0025","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1182\/blood-2014-02-558890","article-title":"Adhesion of Staphylococcus aureus to the vessel wall under flow is mediated by von Willebrand factor\u2010binding protein","volume":"124","author":"Claes","year":"2014","journal-title":"Blood"},{"key":"10.1111\/jth.13501_bb0030","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1189\/jlb.0607373","article-title":"Inflammation, endothelium, and coagulation in sepsis","volume":"83","author":"Schouten","year":"2008","journal-title":"J Leukoc Biol"},{"key":"10.1111\/jth.13501_bb0035","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/CCM.0b013e3181feeb15","article-title":"Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality","volume":"39","author":"Boyd","year":"2011","journal-title":"Crit Care Med"},{"key":"10.1111\/jth.13501_bb0040","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1056\/NEJM198709103171101","article-title":"A controlled clinical trial of high\u2010dose methylprednisolone in the treatment of severe sepsis and septic shock","volume":"317","author":"Bone","year":"1987","journal-title":"N Engl J Med"},{"key":"10.1111\/jth.13501_bb0045","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJMoa1500896","article-title":"Trial of early, goal\u2010directed resuscitation for septic shock","volume":"372","author":"Mouncey","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1111\/jth.13501_bb0050","doi-asserted-by":"crossref","first-page":"8","DOI":"10.5005\/ijccm-14-1-8","article-title":"Severe sepsis bundles","volume":"14","author":"Khan","year":"2010","journal-title":"Indian J Crit Care Med"},{"key":"10.1111\/jth.13501_bb0055","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1001\/jama.2009.1754","article-title":"International study of the prevalence and outcomes of infection in intensive care units","volume":"302","author":"Vincent","year":"2009","journal-title":"JAMA"},{"key":"10.1111\/jth.13501_bb0060","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1146\/annurev.mi.48.100194.003101","article-title":"MSCRAMM\u2010mediated adherence of microorganisms to host tissues","volume":"48","author":"Patti","year":"1994","journal-title":"Annu Rev Microbiol"},{"key":"10.1111\/jth.13501_bb0065","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/ATVBAHA.107.152058","article-title":"Molecular basis for Staphylococcus aureus\u2010mediated platelet aggregate formation under arterial shear in vitro","volume":"28","author":"Kerrigan","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/jth.13501_bb0070","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1080\/01902140500324901","article-title":"Expression of angiostatin, integrin alphavbeta3, and vitronectin in human lungs in sepsis","volume":"31","author":"Singh","year":"2005","journal-title":"Exp Lung Res"},{"key":"10.1111\/jth.13501_bb0075","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/jth.12175","article-title":"Glycoprotein Ibalpha and FcgammaRIIa play key roles in platelet activation by the colonizing bacterium, Streptococcus oralis","volume":"11","author":"Tilley","year":"2013","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.13501_bb0080","first-page":"95","article-title":"Staphylococcal coagulase; mode of action and antigenicity","volume":"6","author":"Duthie","year":"1952","journal-title":"J Gen Microbiol"},{"key":"10.1111\/jth.13501_bb0085","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1365-2958.1994.tb00304.x","article-title":"Molecular characterization of the clumping factor (fibrinogen receptor) of Staphylococcus aureus","volume":"11","author":"McDevitt","year":"1994","journal-title":"Mol Microbiol"},{"key":"10.1111\/jth.13501_bb0090","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1046\/j.1365-2958.1998.01050.x","article-title":"Clumping factor B (ClfB), a new surface\u2010located fibrinogen\u2010binding adhesin of Staphylococcus aureus","volume":"30","author":"Ni Eidhin","year":"1998","journal-title":"Mol Microbiol"},{"key":"10.1111\/jth.13501_bb0095","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/j.1365-2672.1993.tb05195.x","article-title":"Improved cloning vectors and transformation procedure for Lactococcus lactis","volume":"74","author":"Wells","year":"1993","journal-title":"J Appl Bacteriol"},{"key":"10.1111\/jth.13501_bb0100","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1128\/IAI.68.6.3516-3522.2000","article-title":"Expression of Staphylococcus aureus clumping factor A in Lactococcus lactis subsp. cremoris using a new shuttle vector","volume":"68","author":"Que","year":"2000","journal-title":"Infect Immun"},{"key":"10.1111\/jth.13501_bb0105","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/j.1365-2958.2005.04731.x","article-title":"Roles for fibrinogen, immunoglobulin and complement in platelet activation promoted by Staphylococcus aureus clumping factor A","volume":"57","author":"Loughman","year":"2005","journal-title":"Mol Microbiol"},{"key":"10.1111\/jth.13501_bb0110","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1046\/j.1365-2958.2002.02935.x","article-title":"Multiple mechanisms for the activation of human platelet aggregation by Staphylococcus aureus: roles for the clumping factors ClfA and ClfB, the serine\u2010aspartate repeat protein SdrE and protein A","volume":"44","author":"O'Brien","year":"2002","journal-title":"Mol Microbiol"},{"key":"10.1111\/jth.13501_bb0115","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/S0022-3565(24)38272-2","article-title":"Ethanol enhances basal and flow\u2010stimulated nitric oxide synthase activity in vitro by activating an inhibitory guanine nucleotide binding protein","volume":"289","author":"Hendrickson","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1111\/jth.13501_bb0120","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1099\/mic.0.074724-0","article-title":"A short sequence within subdomain N1 of region A of the Staphylococcus aureus MSCRAMM clumping factor A is required for export and surface display","volume":"160","author":"McCormack","year":"2014","journal-title":"Microbiology"},{"key":"10.1111\/jth.13501_bb0125","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1002\/jcp.22655","article-title":"Stabilization of brain microvascular endothelial barrier function by shear stress involves VE\u2010cadherin signaling leading to modulation of pTyr\u2010occludin levels","volume":"226","author":"Walsh","year":"2011","journal-title":"J Cell Physiol"},{"key":"10.1111\/jth.13501_bb0130","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.devcel.2013.08.020","article-title":"VE\u2010cadherin and endothelial adherens junctions: active guardians of vascular integrity","volume":"26","author":"Giannotta","year":"2013","journal-title":"Dev Cell"},{"key":"10.1111\/jth.13501_bb0135","doi-asserted-by":"crossref","first-page":"e18748","DOI":"10.1371\/journal.pone.0018748","article-title":"Staphylococcus aureus protein A binds to osteoblasts and triggers signals that weaken bone in osteomyelitis","volume":"6","author":"Claro","year":"2011","journal-title":"PLoS One"},{"key":"10.1111\/jth.13501_bb0140","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3109\/09537104.2014.997690","article-title":"The expanding field of platelet\u2013bacterial interconnections","volume":"26","author":"Kerrigan","year":"2015","journal-title":"Platelets"},{"key":"10.1111\/jth.13501_bb0145","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1182\/blood-2004-04-1519","article-title":"Vascular endothelial growth factor regulation of Weibel\u2013Palade\u2010body exocytosis","volume":"105","author":"Matsushita","year":"2005","journal-title":"Blood"},{"key":"10.1111\/jth.13501_bb0150","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1111\/j.1742-4658.2006.05482.x","article-title":"Staphylococcus aureus protein A binding to von Willebrand factor A1 domain is mediated by conserved IgG binding regions","volume":"273","author":"O'Seaghdha","year":"2006","journal-title":"FEBS J"},{"key":"10.1111\/jth.13501_bb0155","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00441-008-0706-5","article-title":"Arterial versus venous endothelial cells","volume":"335","author":"dela Paz","year":"2009","journal-title":"Cell Tissue Res"},{"key":"10.1111\/jth.13501_bb0160","doi-asserted-by":"crossref","first-page":"21773","DOI":"10.1074\/jbc.M502529200","article-title":"Binding of ADAMTS13 to von Willebrand factor","volume":"280","author":"Majerus","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.13501_bb0165","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1182\/blood-2005-03-1087","article-title":"Severe secondary deficiency of von Willebrand factor\u2010cleaving protease (ADAMTS13) in patients with sepsis\u2010induced disseminated intravascular coagulation: its correlation with development of renal failure","volume":"107","author":"Ono","year":"2006","journal-title":"Blood"},{"key":"10.1111\/jth.13501_bb0170","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1182\/blood-2008-05-158584","article-title":"Integrin alpha(v)beta(3) on human endothelial cells binds von Willebrand factor strings under fluid shear stress","volume":"113","author":"Huang","year":"2009","journal-title":"Blood"},{"key":"10.1111\/jth.13501_bb0175","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1056\/NEJMcibr1007320","article-title":"Sepsis and endothelial permeability","volume":"363","author":"Lee","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1111\/jth.13501_bb0180","doi-asserted-by":"crossref","first-page":"e4449","DOI":"10.1371\/journal.pone.0004449","article-title":"The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE\u2010cadherin localization at cell junctions and enhances permeability in endothelial cells","volume":"4","author":"Alghisi","year":"2009","journal-title":"PLoS One"},{"key":"10.1111\/jth.13501_bb0185","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1055\/s-0038-1657506","article-title":"Targeted mutations in integrins and their ligands: their implications for vascular biology","volume":"78","author":"Hynes","year":"1997","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.13501_bb0190","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1161\/hh1901.097747","article-title":"Integrins in vascular development","volume":"89","author":"Rupp","year":"2001","journal-title":"Circ Res"},{"key":"10.1111\/jth.13501_bb0195","doi-asserted-by":"crossref","first-page":"pe7","DOI":"10.1126\/stke.2002.119.pe7","article-title":"ECM remodeling regulates angiogenesis: endothelial integrins look for new ligands","volume":"2002","author":"Stupack","year":"2002","journal-title":"Sci STKE"},{"key":"10.1111\/jth.13501_bb0200","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00441-009-0834-6","article-title":"Integrins","volume":"339","author":"Barczyk","year":"2010","journal-title":"Cell Tissue Res"},{"key":"10.1111\/jth.13501_bb0205","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1093\/neuonc\/nou356","article-title":"Two cilengitide regimens in combination with standard treatment for patients with newly diagnosed glioblastoma and unmethylated MGMT gene promoter: results of the open\u2010label, controlled, randomized phase II CORE study","volume":"17","author":"Nabors","year":"2015","journal-title":"Neuro\u2010oncology"},{"key":"10.1111\/jth.13501_bb0210","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1093\/neuonc\/nov018","article-title":"End of the road: confounding results of the CORE trial terminate the arduous journey of cilengitide for glioblastoma","volume":"17","author":"Mason","year":"2015","journal-title":"Neuro\u2010oncology"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.13501","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.13501","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153878362202520X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153878362202520X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/jth.13501\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:12:46Z","timestamp":1761534766000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S153878362202520X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S153878362202520X"],"URL":"https:\/\/doi.org\/10.1111\/jth.13501","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of major integrin \u03b1V\u03b23 reduces Staphylococcus aureus attachment to sheared human endothelial cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/jth.13501","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}