{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T21:33:54Z","timestamp":1781818434527,"version":"3.54.5"},"reference-count":50,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":2163,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003545","name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003545","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Danish Science Foundation"}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1111\/jth.13518","type":"journal-article","created":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T09:18:17Z","timestamp":1475054297000},"page":"2419-2429","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Altered collagen turnover in factor VIII\u2010deficient rats with hemophilic arthropathy identifies potential novel serological biomarkers in hemophilia"],"prefix":"10.1016","volume":"14","author":[{"given":"T.","family":"Manon\u2010Jensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Karsdal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.N.","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kjelgaard\u2010Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Vandahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.H.N.","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Enoksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Roepstorff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/jth.13518_bb0010","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.transci.2007.12.006","article-title":"Hemophilic joint disease \u2010 current perspective and potential future strategies","volume":"38","author":"Acharya","year":"2008","journal-title":"Transfus Apher Sci"},{"key":"10.1111\/jth.13518_bb0015","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1182\/blood-2010-05-284653","article-title":"Neoangiogenesis contributes to the development of hemophilic synovitis","volume":"117","author":"Acharya","year":"2011","journal-title":"Blood"},{"key":"10.1111\/jth.13518_bb0020","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1055\/s-0035-1564445","article-title":"Blood\u2010induced arthropathy in hemophilia: mechanisms and heterogeneity","volume":"41","author":"Blobel","year":"2015","journal-title":"Semin Thromb Hemost"},{"key":"10.1111\/jth.13518_bb0025","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1053\/j.seminhematol.2015.10.005","article-title":"Advances and challenges in hemophilic arthropathy","volume":"53","author":"Wyseure","year":"2016","journal-title":"Semin Hematol"},{"key":"10.1111\/jth.13518_bb0030","doi-asserted-by":"crossref","first-page":"G807","DOI":"10.1152\/ajpgi.00447.2014","article-title":"Novel insights into the function and dynamics of extracellular matrix in liver fibrosis","volume":"308","author":"Karsdal","year":"2015","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1111\/jth.13518_bb0035","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1089\/adt.2012.474","article-title":"Extracellular matrix remodeling: the common denominator in connective tissue diseases. Possibilities for evaluation and current understanding of the matrix as more than a passive architecture, but a key player in tissue failure","volume":"11","author":"Karsdal","year":"2013","journal-title":"Assay Drug Dev Technol"},{"key":"10.1111\/jth.13518_bb0040","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/apt.12820","article-title":"Review article: the efficacy of biomarkers in chronic fibroproliferative diseases \u2010 early diagnosis and prognosis, with liver fibrosis as an exemplar","volume":"40","author":"Karsdal","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1111\/jth.13518_bb0045","doi-asserted-by":"crossref","first-page":"713","DOI":"10.2217\/bmm.13.144","article-title":"Biomarkers of cartilage and surrounding joint tissue","volume":"8","author":"Siebuhr","year":"2014","journal-title":"Biomark Med"},{"key":"10.1111\/jth.13518_bb0050","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1046\/j.1365-2559.1999.00608.x","article-title":"Haemophilic arthropathy resembles degenerative rather than inflammatory joint disease","volume":"34","author":"Roosendaal","year":"1999","journal-title":"Histopathology"},{"key":"10.1111\/jth.13518_bb0055","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S1367-5931(98)80122-1","article-title":"Matrix metalloproteinases","volume":"2","author":"Johnson","year":"1998","journal-title":"Curr Opin Chem Biol"},{"key":"10.1111\/jth.13518_bb0060","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3109\/1354750X.2013.789084","article-title":"Quantification of \u201cend products\u201d of tissue destruction in inflammation may reflect convergence of cytokine and signaling pathways \u2010 implications for modern clinical chemistry","volume":"18","author":"Karsdal","year":"2013","journal-title":"Biomarkers"},{"key":"10.1111\/jth.13518_bb0065","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.clinbiochem.2010.03.015","article-title":"Novel combinations of Post\u2010Translational Modification (PTM) neo\u2010epitopes provide tissue\u2010specific biochemical markers\u2013are they the cause or the consequence of the disease?","volume":"43","author":"Karsdal","year":"2010","journal-title":"Clin Biochem"},{"key":"10.1111\/jth.13518_bb0070","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12931-015-0225-3","article-title":"Accelerated extracellular matrix turnover during exacerbations of COPD","volume":"16","author":"Sand","year":"2015","journal-title":"Respir Res"},{"key":"10.1111\/jth.13518_bb0075","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.surg.2014.09.006","article-title":"The collagen turnover profile is altered in patients with inguinal and incisional hernia","volume":"157","author":"Henriksen","year":"2015","journal-title":"Surgery"},{"key":"10.1111\/jth.13518_bb0080","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nrm3904","article-title":"Remodelling the extracellular matrix in development and disease","volume":"15","author":"Bonnans","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1111\/jth.13518_bb0085","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.joca.2014.09.008","article-title":"Biochemical markers of joint tissue damage increase shortly after a joint bleed; an explorative human and canine in vivo study","volume":"23","author":"van Vulpen","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1111\/jth.13518_bb0090","doi-asserted-by":"crossref","first-page":"R86","DOI":"10.1186\/ar4266","article-title":"Serological identification of fast progressors of structural damage with rheumatoid arthritis","volume":"15","author":"Siebuhr","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"10.1111\/jth.13518_bb0095","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.joca.2013.10.020","article-title":"Identification and characterisation of osteoarthritis patients with inflammation derived tissue turnover","volume":"22","author":"Siebuhr","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1111\/jth.13518_bb0100","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.semarthrit.2013.07.008","article-title":"Effect of tocilizumab combined with methotrexate on circulating biomarkers of synovium, cartilage, and bone in the LITHE study","volume":"43","author":"Bay\u2010Jensen","year":"2014","journal-title":"Semin Arthritis Rheum"},{"key":"10.1111\/jth.13518_bb0105","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1111\/jth.12635","article-title":"A novel F8\u2212\/\u2212 rat as a translational model of human hemophilia A","volume":"12","author":"Nielsen","year":"2014","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.13518_bb0110","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/jth.13328","article-title":"The F8 rat as a model of hemophilic arthropathy","volume":"14","author":"Sorensen","year":"2016","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.13518_bb0115","first-page":"303","article-title":"The neo\u2010epitope specific PRO\u2010C3 ELISA measures true formation of type III collagen associated with liver and muscle parameters","volume":"5","author":"Nielsen","year":"2013","journal-title":"Am J Transl Res"},{"key":"10.1111\/jth.13518_bb0120","doi-asserted-by":"crossref","first-page":"e71050","DOI":"10.1371\/journal.pone.0071050","article-title":"Association of systemic collagen type IV formation with survival among patients undergoing hemodialysis","volume":"8","author":"Leeming","year":"2013","journal-title":"PLoS One"},{"key":"10.1111\/jth.13518_bb0125","doi-asserted-by":"crossref","first-page":"584","DOI":"10.3109\/00365521.2014.996590","article-title":"Pro\u2010C5, a marker of true type V collagen formation and fibrillation, correlates with portal hypertension in patients with alcoholic cirrhosis","volume":"50","author":"Leeming","year":"2015","journal-title":"Scand J Gastroenterol"},{"key":"10.1111\/jth.13518_bb0130","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3109\/1354750X.2011.584131","article-title":"Immunological detection of the type V collagen propeptide fragment, PVCP\u20101230, in connective tissue remodeling associated with liver fibrosis","volume":"16","author":"Vassiliadis","year":"2011","journal-title":"Biomarkers"},{"key":"10.1111\/jth.13518_bb0135","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.clinbiochem.2011.01.001","article-title":"Enzyme\u2010linked immunosorbent assay (ELISAs) for metalloproteinase derived type II collagen neoepitope, CIIM\u2013increased serum CIIM in subjects with severe radiographic osteoarthritis","volume":"44","author":"Bay\u2010Jensen","year":"2011","journal-title":"Clin Biochem"},{"key":"10.1111\/jth.13518_bb0140","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.clinbiochem.2010.03.012","article-title":"A novel assay for extracellular matrix remodeling associated with liver fibrosis: an enzyme\u2010linked immunosorbent assay (ELISA) for a MMP\u20109 proteolytically revealed neo\u2010epitope of type III collagen","volume":"43","author":"Barascuk","year":"2010","journal-title":"Clin Biochem"},{"key":"10.1111\/jth.13518_bb0145","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1755-1536-4-22","article-title":"Assessment of proteolytic degradation of the basement membrane: a fragment of type IV collagen as a biochemical marker for liver fibrosis","volume":"4","author":"Veidal","year":"2011","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1111\/jth.13518_bb0150","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s13539-013-0114-x","article-title":"Type VI collagen turnover\u2010related peptides\u2010novel serological biomarkers of muscle mass and anabolic response to loading in young men","volume":"4","author":"Nedergaard","year":"2013","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1111\/jth.13518_bb0155","doi-asserted-by":"crossref","first-page":"e24753","DOI":"10.1371\/journal.pone.0024753","article-title":"MMP mediated degradation of type VI collagen is highly associated with liver fibrosis\u2013identification and validation of a novel biochemical marker assay","volume":"6","author":"Veidal","year":"2011","journal-title":"PLoS One"},{"key":"10.1111\/jth.13518_bb0160","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/nrc1094","article-title":"Basement membranes: structure, assembly and role in tumour angiogenesis","volume":"3","author":"Kalluri","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"10.1111\/jth.13518_bb0165","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1432-1033.1981.tb05690.x","article-title":"A network model for the organization of type IV collagen molecules in basement membranes","volume":"120","author":"Timpl","year":"1981","journal-title":"Eur J Biochem"},{"key":"10.1111\/jth.13518_bb0170","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0014-5793(81)81012-5","article-title":"Macromolecular structure of basement membrane collagens","volume":"125","author":"Kuhn","year":"1981","journal-title":"FEBS Lett"},{"key":"10.1111\/jth.13518_bb0175","doi-asserted-by":"crossref","first-page":"R165","DOI":"10.1186\/ar2073","article-title":"Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal\/fibrotic characteristics","volume":"8","author":"Steenvoorden","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"10.1111\/jth.13518_bb0180","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1002\/art.23072","article-title":"Type IV collagen alpha\u2010chain composition in synovial lining from trauma patients and patients with rheumatoid arthritis","volume":"56","author":"Poduval","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1111\/jth.13518_bb0185","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/ajh.24133","article-title":"Vascular remodeling underlies rebleeding in hemophilic arthropathy","volume":"90","author":"Bhat","year":"2015","journal-title":"Am J Hematol"},{"key":"10.1111\/jth.13518_bb0190","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/ejh.12227","article-title":"Angiogenesis is increased in advanced haemophilic joint disease and characterised by normal pericyte coverage","volume":"92","author":"Zetterberg","year":"2014","journal-title":"Eur J Haematol"},{"key":"10.1111\/jth.13518_bb0195","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1053\/S0270-9295(03)00131-1","article-title":"Pathogenesis of Goodpasture syndrome: a molecular perspective","volume":"23","author":"Borza","year":"2003","journal-title":"Semin Nephrol"},{"key":"10.1111\/jth.13518_bb0200","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1182\/blood-2006-05-020495","article-title":"Cutaneous wound healing is impaired in hemophilia B","volume":"108","author":"Hoffman","year":"2006","journal-title":"Blood"},{"key":"10.1111\/jth.13518_bb0205","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/j.1538-7836.2007.02647.x","article-title":"Restoring hemostatic thrombin generation at the time of cutaneous wounding does not normalize healing in hemophilia B","volume":"5","author":"McDonald","year":"2007","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.13518_bb0210","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/1479-5876-10-195","article-title":"Matrix metalloproteinase\u2010dependent turnover of cartilage, synovial membrane, and connective tissue is elevated in rats with collagen induced arthritis","volume":"10","author":"Siebuhr","year":"2012","journal-title":"J Transl Med"},{"key":"10.1111\/jth.13518_bb0215","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.phrs.2008.06.007","article-title":"The immune system and cardiac repair","volume":"58","author":"Frangogiannis","year":"2008","journal-title":"Pharmacol Res"},{"key":"10.1111\/jth.13518_bb0220","doi-asserted-by":"crossref","first-page":"26522","DOI":"10.1074\/jbc.272.42.26522","article-title":"Type VI collagen anchors endothelial basement membranes by interacting with type IV collagen","volume":"272","author":"Kuo","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.13518_bb0225","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0002-9440(10)63889-8","article-title":"Short\u2010term exposure of cartilage to blood results in chondrocyte apoptosis","volume":"162","author":"Hooiveld","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1111\/jth.13518_bb0230","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/art.22304","article-title":"Exposure of human cartilage tissue to low concentrations of blood for a short period of time leads to prolonged cartilage damage: an in vitro study","volume":"56","author":"Jansen","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1111\/jth.13518_bb0235","doi-asserted-by":"crossref","first-page":"648459","DOI":"10.1155\/2014\/648459","article-title":"The ECM\u2010cell interaction of cartilage extracellular matrix on chondrocytes","volume":"2014","author":"Gao","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1111\/jth.13518_bb0240","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1042\/bj2480373","article-title":"Type VI collagen of the intervertebral disc. Biochemical and electron\u2010microscopic characterization of the native protein","volume":"248","author":"Wu","year":"1987","journal-title":"Biochem J"},{"key":"10.1111\/jth.13518_bb0245","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1101\/gad.9.22.2821","article-title":"Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone","volume":"9","author":"Li","year":"1995","journal-title":"Genes Dev"},{"key":"10.1111\/jth.13518_bb0250","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.joca.2014.12.019","article-title":"Treatment of symptomatic knee osteoarthritis with oral salmon calcitonin: results from two phase 3 trials","volume":"23","author":"Karsdal","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1111\/jth.13518_bb0255","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/art.24184","article-title":"The combination of the biomarkers urinary C\u2010terminal telopeptide of type II collagen, serum cartilage oligomeric matrix protein, and serum chondroitin sulfate 846 reflects cartilage damage in hemophilic arthropathy","volume":"60","author":"Jansen","year":"2009","journal-title":"Arthritis Rheum"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.13518","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.13518","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622025326?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622025326?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/jth.13518\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:13:57Z","timestamp":1761534837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622025326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":50,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S1538783622025326"],"URL":"https:\/\/doi.org\/10.1111\/jth.13518","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered collagen turnover in factor VIII\u2010deficient rats with hemophilic arthropathy identifies potential novel serological biomarkers in hemophilia","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/jth.13518","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}