{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:52:36Z","timestamp":1772160756294,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":1916,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National S & T Major Projects of China","award":["2014ZX09101043002"],"award-info":[{"award-number":["2014ZX09101043002"]}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["14431904100"],"award-info":[{"award-number":["14431904100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["YG2013MS09"],"award-info":[{"award-number":["YG2013MS09"]}],"id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013286","name":"SRFDP","doi-asserted-by":"crossref","award":["20130073120110"],"award-info":[{"award-number":["20130073120110"]}],"id":[{"id":"10.13039\/501100013286","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1111\/jth.13561","type":"journal-article","created":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T04:59:51Z","timestamp":1478235591000},"page":"122-130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Coagulation factor XI vaccination: an alternative strategy to prevent thrombosis"],"prefix":"10.1016","volume":"15","author":[{"given":"C.","family":"Zhong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1111\/jth.13561_bb0010","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3109\/07853890.2010.539250","article-title":"Old and new anticoagulant drugs: a minireview","volume":"43","author":"Mannucci","year":"2011","journal-title":"Ann Med"},{"key":"10.1111\/jth.13561_bb0015","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nrcardio.2012.61","article-title":"Direct thrombin inhibitors in cardiovascular disease","volume":"9","author":"Arsenault","year":"2012","journal-title":"Nat Rev Cardiol"},{"key":"10.1111\/jth.13561_bb0020","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1111\/j.1538-7836.2011.04432.x","article-title":"Bleeding risk and reversal strategies for old and new anticoagulants and antiplatelet agents","volume":"9","author":"Levi","year":"2011","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.13561_bb0025","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1097\/MOH.0b013e328365a164","article-title":"Novel thrombin and factor Xa inhibitors: challenges to reversal of their anticoagulation effects","volume":"20","author":"Yates","year":"2013","journal-title":"Curr Opin Hematol"},{"key":"10.1111\/jth.13561_bb0030","first-page":"175","article-title":"The evolution of anticoagulant therapy","volume":"14","author":"Franchini","year":"2016","journal-title":"Blood Transfus"},{"key":"10.1111\/jth.13561_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jth.13005","article-title":"Factor XI and contact activation as targets for antithrombotic therapy","volume":"13","author":"Gailani","year":"2015","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.13561_bb0040","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.drudis.2014.04.018","article-title":"Inhibition of factor XI activity as a promising antithrombotic strategy","volume":"19","author":"Chen","year":"2014","journal-title":"Drug Discovery Today"},{"key":"10.1111\/jth.13561_bb0045","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.drudis.2014.05.018","article-title":"Factor XI as a target for antithrombotic therapy","volume":"19","author":"Bane","year":"2014","journal-title":"Drug Discovery Today"},{"key":"10.1111\/jth.13561_bb0050","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1056\/NEJMoa1405760","article-title":"Factor XI antisense oligonucleotide for prevention of venous thrombosis","volume":"372","author":"Buller","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1111\/jth.13561_bb0055","doi-asserted-by":"crossref","first-page":"561","DOI":"10.2217\/imt.10.30","article-title":"Immunodrugs: breaking B\u2010 but not T\u2010cell tolerance with therapeutic anticytokine vaccines","volume":"2","author":"Link","year":"2010","journal-title":"Immunotherapy"},{"key":"10.1111\/jth.13561_bb0060","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/j.vaccine.2013.02.001","article-title":"Active immunotherapy for chronic diseases","volume":"31","author":"Bachmann","year":"2013","journal-title":"Vaccine"},{"key":"10.1111\/jth.13561_bb0065","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.vph.2006.08.004","article-title":"Vaccines for the prevention of cardiovascular disease","volume":"45","author":"Ryan","year":"2006","journal-title":"Vascul Pharmacol"},{"key":"10.1111\/jth.13561_bb0070","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.bbrc.2013.09.031","article-title":"A DNA vaccine against cytotoxic T\u2010lymphocyte associated antigen\u20104 (CTLA\u20104) prevents tumor growth","volume":"440","author":"Lan","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/jth.13561_bb0075","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.bbrc.2013.04.057","article-title":"Prophylactic effect of a peptide vaccine targeting TM4SF5 against colon cancer in a mouse model","volume":"435","author":"Kwon","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/jth.13561_bb0080","doi-asserted-by":"crossref","first-page":"e114469","DOI":"10.1371\/journal.pone.0114469","article-title":"Peptide\u2010based anti\u2010PCSK9 vaccines \u2013 an approach for long\u2010term LDLc management","volume":"9","author":"Galabova","year":"2014","journal-title":"PLoS One"},{"key":"10.1111\/jth.13561_bb0085","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1194\/jlr.M028340","article-title":"Immunization against proprotein convertase subtilisin\u2010like\/kexin type 9 lowers plasma LDL\u2010cholesterol levels in mice","volume":"53","author":"Fattori","year":"2012","journal-title":"J Lipid Res"},{"key":"10.1111\/jth.13561_bb0090","doi-asserted-by":"crossref","first-page":"e0003684","DOI":"10.1371\/journal.pntd.0003684","article-title":"A small antigenic determinant of the Chikungunya virus E2 protein is sufficient to induce neutralizing antibodies which are partially protective in mice","volume":"9","author":"Weber","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1111\/jth.13561_bb0095","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0165-2427(03)00069-2","article-title":"Staphylococcus aureus vaccine against mastitis in dairy cows, composition and evaluation of its immunogenicity in a mouse model","volume":"93","author":"Leitner","year":"2003","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1111\/jth.13561_bb0100","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/hae.12374","article-title":"Evaluation of the activated partial thromboplastin time assay for clinical monitoring of PEGylated recombinant factor VIII (BAY 94\u20109027) for haemophilia A","volume":"20","author":"Gu","year":"2014","journal-title":"Haemophilia"},{"key":"10.1111\/jth.13561_bb0105","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1538-7836.2010.04098.x","article-title":"Effects of the oral, direct factor Xa inhibitor rivaroxaban on commonly used coagulation assays","volume":"9","author":"Hillarp","year":"2011","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.13561_bb0110","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1182\/blood-2010-05-287623","article-title":"von Willebrand factor\u2010mediated platelet adhesion is critical for deep vein thrombosis in mouse models","volume":"117","author":"Brill","year":"2011","journal-title":"Blood"},{"key":"10.1111\/jth.13561_bb0115","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/jth.12866","article-title":"Inferior vena cava branch variations in C57BL\/6 mice have an impact on thrombus size in an IVC ligation (stasis) model","volume":"13","author":"Diaz","year":"2015","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.13561_bb0120","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1939-165X.2012.00405.x","article-title":"Evaluation of the impedance analyzer PocH\u2010100iV Diff for analysis of canine and feline blood","volume":"41","author":"Bauer","year":"2012","journal-title":"Vet Clin Pathol"},{"key":"10.1111\/jth.13561_bb0125","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/pim.12138","article-title":"Matrix metalloproteinase (MMP)\u20102 and MMP\u20109 as inflammation markers of Trichinella spiralis and Trichinella pseudospiralis infections in mice","volume":"36","author":"Bruschi","year":"2014","journal-title":"Parasite Immunol"},{"key":"10.1111\/jth.13561_bb0130","doi-asserted-by":"crossref","first-page":"e160","DOI":"10.1016\/j.thromres.2011.07.044","article-title":"Treatment with unfractionated heparin attenuates coagulation and inflammation in endotoxemic mice","volume":"128","author":"Ding","year":"2011","journal-title":"Thromb Res"},{"key":"10.1111\/jth.13561_bb0135","doi-asserted-by":"crossref","first-page":"4684","DOI":"10.1182\/blood-2010-04-277798","article-title":"Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk","volume":"116","author":"Zhang","year":"2010","journal-title":"Blood"},{"key":"10.1111\/jth.13561_bb0140","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1182\/blood-2002-05-1470","article-title":"Protection against thrombosis in mice lacking PAR3","volume":"100","author":"Weiss","year":"2002","journal-title":"Blood"},{"key":"10.1111\/jth.13561_bb0145","first-page":"1569","article-title":"The anti\u2010leukemic Bruton's tyrosine kinase inhibitor alpha\u2010cyano\u2010beta\u2010hydroxy\u2010beta\u2010methyl\u2010N\u2010(2,5\u2010dibromophenyl) propenamide (LFM\u2010A13) prevents fatal thromboembolism","volume":"44","author":"Uckun","year":"2003","journal-title":"Leukemia Lymphoma"},{"key":"10.1111\/jth.13561_bb0150","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1161\/01.ATV.0000146531.79402.9a","article-title":"Inhibition of endogenous leptin protects mice from arterial and venous thrombosis","volume":"24","author":"Konstantinides","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/jth.13561_bb0155","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1172\/JCI11849","article-title":"Conjugation of a self\u2010antigen to papillomavirus\u2010like particles allows for efficient induction of protective autoantibodies","volume":"108","author":"Chackerian","year":"2001","journal-title":"J Clin Investig"},{"key":"10.1111\/jth.13561_bb0160","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1086\/315324","article-title":"Universal epitopes for human CD4+ cells on tetanus and diphtheria toxins","volume":"181","author":"Diethelm\u2010Okita","year":"2000","journal-title":"J Infect Dis"},{"key":"10.1111\/jth.13561_bb0165","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1097\/00029330-200709010-00010","article-title":"Active immunotherapy of allergic asthma with a recombinant human interleukin\u20105 protein as vaccine in a murine model","volume":"120","author":"Tan","year":"2007","journal-title":"Chin Med J (Engl)"},{"key":"10.1111\/jth.13561_bb0170","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1084\/jem.20112322","article-title":"Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo","volume":"209","author":"von Bruhl","year":"2012","journal-title":"J Exp Med"},{"key":"10.1111\/jth.13561_bb0175","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1161\/ATVBAHA.113.301282","article-title":"Antithrombotic effect of antisense factor XI oligonucleotide treatment in primates","volume":"33","author":"Crosby","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/jth.13561_bb0180","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1182\/blood-2011-10-387134","article-title":"Antisense inhibition of coagulation factor XI prolongs APTT without increased bleeding risk in cynomolgus monkeys","volume":"119","author":"Younis","year":"2012","journal-title":"Blood"},{"key":"10.1111\/jth.13561_bb0185","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1128\/IAI.05568-11","article-title":"Factor XI\u2010deficient mice display reduced inflammation, coagulopathy, and bacterial growth during listeriosis","volume":"80","author":"Luo","year":"2012","journal-title":"Infect Immun"},{"key":"10.1111\/jth.13561_bb0190","doi-asserted-by":"crossref","first-page":"e0152968","DOI":"10.1371\/journal.pone.0152968","article-title":"Factor XI deficiency alters the cytokine response and activation of contact proteases during polymicrobial sepsis in mice","volume":"11","author":"Bane","year":"2016","journal-title":"PLoS One"},{"key":"10.1111\/jth.13561_bb0195","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1086\/589514","article-title":"Survival advantage of coagulation factor XI\u2010deficient mice during peritoneal sepsis","volume":"198","author":"Tucker","year":"2008","journal-title":"J Infect Dis"},{"key":"10.1111\/jth.13561_bb0200","doi-asserted-by":"crossref","first-page":"5569","DOI":"10.1038\/sj.emboj.7601422","article-title":"The contact system \u2013 a novel branch of innate immunity generating antibacterial peptides","volume":"25","author":"Frick","year":"2006","journal-title":"EMBO J"},{"key":"10.1111\/jth.13561_bb0205","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1056\/NEJMe1413874","article-title":"Making (anti)sense of factor XI in thrombosis","volume":"372","author":"Flaumenhaft","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1111\/jth.13561_bb0210","doi-asserted-by":"crossref","first-page":"I22","DOI":"10.1161\/01.CIR.0000078464.82671.78","article-title":"Natural history of venous thromboembolism","volume":"107","author":"Kearon","year":"2003","journal-title":"Circulation"},{"key":"10.1111\/jth.13561_bb0215","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1160\/TH09-03-0172","article-title":"Recombinant activated factor VII and tranexamic acid are haemostatically effective during major surgery in factor XI\u2010deficient patients with inhibitor antibodies","volume":"102","author":"Livnat","year":"2009","journal-title":"Thromb Haemost"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.13561","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.13561","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622031634?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622031634?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/jth.13561\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:17:15Z","timestamp":1761535035000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622031634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S1538783622031634"],"URL":"https:\/\/doi.org\/10.1111\/jth.13561","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726924297.793527973","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.726924297.793529217","asserted-by":"object"}]},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Coagulation factor XI vaccination: an alternative strategy to prevent thrombosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/jth.13561","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 The Authors. Journal of Thrombosis and Haemostasis. Published by ELSEVIER INC. on behalf of International Society on Thrombosis and Haemostasis","name":"copyright","label":"Copyright"}]}}