{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:09:56Z","timestamp":1763017796666,"version":"build-2065373602"},"reference-count":26,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":1898,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100010849","name":"Health and Family Planning Commission of Wuhan Municipality","doi-asserted-by":"crossref","award":["WX14D11"],"award-info":[{"award-number":["WX14D11"]}],"id":[{"id":"10.13039\/501100010849","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Innovation Fund of Wuhan Asia Heart Hospital","award":["2013CX2-A06"],"award-info":[{"award-number":["2013CX2-A06"]}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1111\/jth.13782","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T05:49:08Z","timestamp":1501566548000},"page":"1934-1941","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["D\u2010dimer to guide the intensity of anticoagulation in Chinese patients after mechanical heart valve replacement: a randomized controlled trial"],"prefix":"10.1016","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4918-611X","authenticated-orcid":false,"given":"L.","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1111\/jth.13782_bb0010","doi-asserted-by":"crossref","first-page":"e576S","DOI":"10.1378\/chest.11-2305","article-title":"Antithrombotic and thrombolytic therapy for valvular disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence\u2010Based Clinical Practice Guidelines","volume":"141","author":"Whitlock","year":"2012","journal-title":"Chest"},{"key":"10.1111\/jth.13782_bb0015","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s12013-011-9275-4","article-title":"Low\u2010intensity international normalized ratio (INR) oral anticoagulant therapy in Chinese patients with mechanical heart valve prostheses","volume":"62","author":"Haibo","year":"2012","journal-title":"Cell Biochem Biophys"},{"key":"10.1111\/jth.13782_bb0020","first-page":"361","article-title":"Anticoagulation intensity with warfarin for Chinese people after mechanical valve replacement: a systematic review","volume":"37","author":"Wang","year":"2010","journal-title":"Int J Cardiovasc Dis"},{"key":"10.1111\/jth.13782_bb0025","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1378\/chest.12-3077","article-title":"Antithrombotic and thrombolytic therapy for valvular disease: can this guideline apply to Chinese?(letter)","volume":"143","author":"Fu","year":"2013","journal-title":"Chest"},{"key":"10.1111\/jth.13782_bb0030","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/j.1365-2125.2005.02361.x","article-title":"Is INR between 2.0 and 3.0 the optimal level for Chinese patients on warfarin therapy for moderate\u2010intensity anticoagulation?","volume":"59","author":"You","year":"2005","journal-title":"Br J Clin Pharmacol"},{"key":"10.1111\/jth.13782_bb0035","first-page":"90","article-title":"Low intensity anticoagulation therapy for chinese population with heart valve replacement\u20133 000 cases follow\u2010up","volume":"47","author":"Xu","year":"2016","journal-title":"J Sichuan Univ (Med Sci Edi)"},{"key":"10.1111\/jth.13782_bb0040","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1046\/j.1525-1594.1999.06110.x","article-title":"Anticoagulation after valve replacement: a multicenter retrospective study","volume":"23","author":"Kudo","year":"1999","journal-title":"Artif Organs"},{"key":"10.1111\/jth.13782_bb0045","first-page":"69","article-title":"How to use D\u2010dimer in acute cardiovascular care","volume":"6","author":"Giannitsis","year":"2017","journal-title":"Eur Heart J Acute Cardiovasc Car"},{"key":"10.1111\/jth.13782_bb0050","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1016\/j.jacc.2009.12.049","article-title":"Evidence that D\u2010dimer levels predict subsequent thromboembolic and cardiovascular events in patients with atrial fibrillation during oral anticoagulant therapy","volume":"55","author":"Sadanaga","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1111\/jth.13782_bb0055","doi-asserted-by":"crossref","first-page":"c1475","DOI":"10.1136\/bmj.c1475","article-title":"Potential of an age adjusted D\u2010dimer cut\u2010off value to improve the exclusion of pulmonary embolism in older patients: a retrospective analysis of three large cohorts","volume":"340","author":"Douma","year":"2010","journal-title":"BMJ"},{"key":"10.1111\/jth.13782_bb0060","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/j.athoracsur.2007.12.082","article-title":"Sts, Aats, Eacts. Guidelines for reporting mortality and morbidity after cardiac valve interventions","volume":"85","author":"Akins","year":"2008","journal-title":"Ann Thorac Surg"},{"key":"10.1111\/jth.13782_bb0065","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1538-7836.2005.01204.x","article-title":"Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non\u2010surgical patients","volume":"3","author":"Schulman","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.13782_bb0070","first-page":"236","article-title":"Relationship of international normalized ratio to bleeding and thromboembolism rates in Taiwanese patients receiving vitamin K antagonist after mechanical valve replacement","volume":"104","author":"Yu","year":"2005","journal-title":"J Formos Med Assoc"},{"key":"10.1111\/jth.13782_bb0075","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1378\/chest.127.1.53","article-title":"Thromboembolic and bleeding complications following St. Jude Medical valve replacement: results of the German Experience With Low\u2010Intensity Anticoagulation Study","volume":"127","author":"Hering","year":"2005","journal-title":"Chest"},{"key":"10.1111\/jth.13782_bb0080","first-page":"411","article-title":"German experience with low intensity anticoagulation (GELIA): protocol of a multi\u2010center randomized, prospective study with the St. Jude Medical valve","volume":"2","author":"Horstkotte","year":"1993","journal-title":"J Heart Valve Dis"},{"key":"10.1111\/jth.13782_bb0085","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1055\/s-0038-1656064","article-title":"A comparison of a moderate with moderate\u2010high intensity oral anticoagulant treatment in patients with mechanical heart valve prostheses","volume":"77","author":"Pengo","year":"1997","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.13782_bb0090","first-page":"76","article-title":"China expert consensus on warfarin anticoagulation therapy [in Chinese]","volume":"52","year":"2013","journal-title":"Chin J Intern Med"},{"key":"10.1111\/jth.13782_bb0095","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0140-6736(06)68263-9","article-title":"Seven haemostatic gene polymorphisms in coronary disease: meta\u2010analysis of 66,155 cases and 91,307 controls","volume":"367","author":"Ye","year":"2006","journal-title":"Lancet"},{"key":"10.1111\/jth.13782_bb0100","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1111\/j.1538-7836.2006.02237.x","article-title":"Plasma hemostatic factors and endothelial markers in four racial\/ethnic groups: the MESA study","volume":"4","author":"Lutsey","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.13782_bb0105","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ijcard.2010.07.002","article-title":"First direct comparison of platelet reactivity and thrombolytic status between Japanese and Western volunteers: possible relationship to the \u201cJapanese paradox\u201d","volume":"152","author":"Gorog","year":"2011","journal-title":"Int J Cardiol"},{"key":"10.1111\/jth.13782_bb0110","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jacc.2007.01.098","article-title":"Racial\/ethnic differences in the risk of intracranial hemorrhage among patients with atrial fibrillation","volume":"50","author":"Shen","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1111\/jth.13782_bb0115","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1161\/01.ATV.17.7.1320","article-title":"D\u2010dimer and anticoagulation in patients with mechanical prosthetic heart valves. A 2\u2010year follow\u2010up","volume":"17","author":"Giansante","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/jth.13782_bb0120","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.thromres.2011.08.014","article-title":"A multicentric prospective study in usual care: D\u2010dimer and cardiovascular events in patients with atrial fibrillation","volume":"129","author":"Mahe","year":"2012","journal-title":"Thromb Res"},{"key":"10.1111\/jth.13782_bb0125","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1111\/jth.12638","article-title":"D\u2010dimer and risk of thromboembolic and bleeding events in patients with atrial fibrillation\u2013observations from the ARISTOTLE trial","volume":"12","author":"Christersson","year":"2014","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.13782_bb0130","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1136\/hrt.73.6.527","article-title":"Increased markers of thrombogenesis in chronic atrial fibrillation: effects of warfarin treatment","volume":"73","author":"Lip","year":"1995","journal-title":"Br Heart J"},{"key":"10.1111\/jth.13782_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0049-3848(02)00184-6","article-title":"D\u2010dimer: a characteristic of the coagulation state of each patient with chronic atrial fibrillation","volume":"107","author":"Mahe","year":"2002","journal-title":"Thromb Res"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.13782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622043549?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622043549?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/jth.13782\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:16:01Z","timestamp":1761534961000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622043549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S1538783622043549"],"URL":"https:\/\/doi.org\/10.1111\/jth.13782","relation":{},"ISSN":["1538-7836"],"issn-type":[{"type":"print","value":"1538-7836"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"D\u2010dimer to guide the intensity of anticoagulation in Chinese patients after mechanical heart valve replacement: a randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/jth.13782","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2017 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}