{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T21:58:47Z","timestamp":1778104727600,"version":"3.51.4"},"reference-count":45,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":1804,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL103419"],"award-info":[{"award-number":["R01 HL103419"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32HL007954-15"],"award-info":[{"award-number":["5T32HL007954-15"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32HL007954-18"],"award-info":[{"award-number":["5T32HL007954-18"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1 HL120877"],"award-info":[{"award-number":["UM1 HL120877"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 HL131053"],"award-info":[{"award-number":["U01 HL131053"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1111\/jth.13863","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T10:16:20Z","timestamp":1507198580000},"page":"2396-2407","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Soluble fibrin causes an acquired platelet glycoprotein VI signaling defect: implications for coagulopathy"],"prefix":"10.1016","volume":"15","author":[{"given":"M.Y.","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.C.","family":"Verni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.A.","family":"Herbig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.L.","family":"Diamond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1111\/jth.13863_bb0010","first-page":"748","article-title":"The coagulopathy of trauma: a review of mechanisms","volume":"65","author":"Hess","year":"2008","journal-title":"J Trauma"},{"key":"10.1111\/jth.13863_bb0015","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/TA.0b013e31825b5c10","article-title":"Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy","volume":"73","author":"Ostrowski","year":"2012","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1111\/jth.13863_bb0020","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.injury.2007.10.003","article-title":"Systemic inflammation after trauma","volume":"38","author":"Lenz","year":"2007","journal-title":"Injury"},{"key":"10.1111\/jth.13863_bb0025","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/00003246-200002000-00026","article-title":"Changes of the hemostatic network in critically ill patients\u2013is there a difference between sepsis, trauma, and neurosurgery patients?","volume":"28","author":"Boldt","year":"2000","journal-title":"Crit Care Med"},{"key":"10.1111\/jth.13863_bb0030","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1089\/0897715041526212","article-title":"Proteome study of human cerebrospinal fluid following traumatic brain injury indicates fibrin(ogen) degradation products as trauma\u2010associated markers","volume":"21","author":"Conti","year":"2004","journal-title":"J Neurotrauma"},{"key":"10.1111\/jth.13863_bb0035","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1097\/01.TA.0000069184.82147.06","article-title":"Acute traumatic coagulopathy","volume":"54","author":"Brohi","year":"2003","journal-title":"J Trauma"},{"key":"10.1111\/jth.13863_bb0040","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1097\/TA.0000000000001017","article-title":"A prospective study of platelet function in trauma patients","volume":"80","author":"Ramsey","year":"2016","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1111\/jth.13863_bb0045","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0049-3848(95)00137-G","article-title":"Soluble fibrin in plasma before and after surgery for benign and malignant colorectal disease","volume":"79","author":"Iversen","year":"1995","journal-title":"Thromb Res"},{"key":"10.1111\/jth.13863_bb0050","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.surg.2013.02.004","article-title":"Normal prothrombinase activity, increased systemic thrombin activity, and lower antithrombin levels in patients with disseminated intravascular coagulation at an early phase of trauma: comparison with acute coagulopathy of trauma\u2010shock","volume":"154","author":"Yanagida","year":"2013","journal-title":"Surgery"},{"key":"10.1111\/jth.13863_bb0055","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1055\/s-0037-1615025","article-title":"Significant correlations between tissue factor and thrombin markers in trauma and septic patients with disseminated intravascular coagulation","volume":"79","author":"Gando","year":"1998","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.13863_bb0060","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s00540-008-0731-2","article-title":"Discrepancy between soluble fibrin and D\u2010dimer levels among sampling sites in elderly patients with femoral neck fracture","volume":"23","author":"Sakai","year":"2009","journal-title":"J Anesth"},{"key":"10.1111\/jth.13863_bb0065","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/MBC.0b013e3283646659","article-title":"The clinical utility of fibrin\u2010related biomarkers in sepsis","volume":"24","author":"Toh","year":"2013","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1111\/jth.13863_bb0070","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0167-5273(98)00256-3","article-title":"Prothrombin fragments F1+2, thrombin\u2010antithrombin III complexes, fibrin monomers and fibrinogen in patients with coronary atherosclerosis","volume":"68","author":"Giannitsis","year":"1999","journal-title":"Int J Cardiol"},{"key":"10.1111\/jth.13863_bb0075","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1111\/ijlh.12117","article-title":"The evaluation of two automated soluble fibrin assays for use in the routine hospital laboratory","volume":"35","author":"Westerlund","year":"2013","journal-title":"Int J Lab Hematol"},{"key":"10.1111\/jth.13863_bb0080","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jvs.2005.03.042","article-title":"Clinical implication of plasma level of soluble fibrin monomer\u2010fibrinogen complex in patients with abdominal aortic aneurysm","volume":"42","author":"Hosaka","year":"2005","journal-title":"J Vasc Surg"},{"key":"10.1111\/jth.13863_bb0085","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/SHK.0000000000000281","article-title":"Noble\u2010Collip drum trauma induces disseminated intravascular coagulation but not acute coagulopathy of trauma\u2010shock","volume":"43","author":"Hayakawa","year":"2015","journal-title":"Shock"},{"key":"10.1111\/jth.13863_bb0090","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.jamcollsurg.2012.01.050","article-title":"Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma","volume":"214","author":"Wohlauer","year":"2012","journal-title":"J Am Coll Surg"},{"key":"10.1111\/jth.13863_bb0095","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12028-012-9745-6","article-title":"Platelet dysfunction is an early marker for traumatic brain injury\u2010induced coagulopathy","volume":"18","author":"Davis","year":"2013","journal-title":"Neurocrit Care"},{"key":"10.1111\/jth.13863_bb0100","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/TA.0b013e318256deab","article-title":"Characterization of platelet dysfunction after trauma","volume":"73","author":"Kutcher","year":"2012","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1111\/jth.13863_bb0105","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/TA.0000000000000915","article-title":"Ex vivo recapitulation of trauma\u2010induced coagulopathy and preliminary assessment of trauma patient platelet function under flow using microfluidic technology","volume":"80","author":"Li","year":"2016","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1111\/jth.13863_bb0110","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1182\/blood-2015-04-641654","article-title":"Fibrin activates GPVI in human and mouse platelets","volume":"126","author":"Alshehri","year":"2015","journal-title":"Blood"},{"key":"10.1111\/jth.13863_bb0115","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.tips.2012.07.004","article-title":"Platelet GPVI: a target for antithrombotic therapy?!","volume":"33","author":"D\u00fctting","year":"2012","journal-title":"Trends Pharmacol Sci"},{"key":"10.1111\/jth.13863_bb0120","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.yjmcc.2010.04.009","article-title":"Impact of glycoprotein VI and platelet adhesion on atherosclerosis\u2010A possible role of fibronectin","volume":"49","author":"B\u00fcltmann","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"10.1111\/jth.13863_bb0125","doi-asserted-by":"crossref","first-page":"C757","DOI":"10.1152\/ajpcell.00060.2012","article-title":"The dimeric platelet collagen receptor GPVI\u2010Fc reduces platelet adhesion to activated endothelium and preserves myocardial function after transient ischemia in mice","volume":"303","author":"Sch\u00f6nberger","year":"2012","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1111\/jth.13863_bb0130","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1182\/blood-2005-06-2406","article-title":"Laminin stimulates spreading of platelets through integrin alpha6beta1\u2010dependent activation of GPVI","volume":"107","author":"Inoue","year":"2006","journal-title":"Blood"},{"key":"10.1111\/jth.13863_bb0135","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1182\/blood-2015-02-629717","article-title":"Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation","volume":"126","author":"Mammadova\u2010Bach","year":"2015","journal-title":"Blood"},{"key":"10.1111\/jth.13863_bb0140","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1538-7836.2011.04361.x","article-title":"Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke","volume":"9","author":"Nieswandt","year":"2011","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1111\/jth.13863_bb0145","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/00008506-199404000-00002","article-title":"Soluble fibrin and d\u2010dimer as detectors of hypercoagulability in patients with isolated brain trauma","volume":"6","author":"Bredbacka","year":"1994","journal-title":"J\u00a0Neurosurg Anesthesiol"},{"key":"10.1111\/jth.13863_bb0150","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/00003246-199801000-00031","article-title":"Procoagulant activity in patients with isolated severe head trauma","volume":"26","author":"Scherer","year":"1998","journal-title":"Crit Care Med"},{"key":"10.1111\/jth.13863_bb0155","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1055\/s-2007-995857","article-title":"Hemostatic molecular markers before onset of disseminated intravascular coagulation in leukemic patients","volume":"24","author":"Wada","year":"1998","journal-title":"Semin Thromb Hemost"},{"key":"10.1111\/jth.13863_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pcbi.1004118","article-title":"A human platelet calcium calculator trained by pairwise agonist scanning","volume":"11","author":"Lee","year":"2015","journal-title":"PLoS Comput Biol"},{"key":"10.1111\/jth.13863_bb0165","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1039\/b919728a","article-title":"P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions","volume":"2","author":"Maloney","year":"2010","journal-title":"Integr Biol"},{"key":"10.1111\/jth.13863_bb0170","doi-asserted-by":"crossref","first-page":"30434","DOI":"10.1074\/jbc.M701330200","article-title":"Ligand binding rapidly induces disulfide\u2010dependent dimerization of glycoprotein VI on the platelet plasma membrane","volume":"282","author":"Arthur","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.13863_bb0175","doi-asserted-by":"crossref","first-page":"30000","DOI":"10.1074\/jbc.M112.359125","article-title":"Constitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowing blood","volume":"287","author":"Jung","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.13863_bb0180","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1182\/blood-2012-09-457739","article-title":"Hierarchical organization in the hemostatic response and its relationship to the platelet signaling network","volume":"121","author":"Stalker","year":"2013","journal-title":"Blood"},{"key":"10.1111\/jth.13863_bb0185","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1365-2141.1995.tb08900.x","article-title":"Platelets with 10% of the normal amount of glycoprotein VI have an impaired response to collagen that results in a mild bleeding tendency","volume":"89","author":"Arai","year":"1995","journal-title":"Br J Haematol"},{"key":"10.1111\/jth.13863_bb0190","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1161\/ATVBAHA.114.304244","article-title":"Redundancy and interaction of thrombin\u2010 and collagen\u2010mediated platelet activation in tail bleeding and carotid thrombosis in mice","volume":"34","author":"Bynagari\u2010Settipalli","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/jth.13863_bb0195","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1182\/bloodadvances.2017007732","article-title":"Fibrin and D\u2010dimer bind to monomeric GPVI","volume":"1","author":"Onselaer","year":"2017","journal-title":"Blood Advances"},{"key":"10.1111\/jth.13863_bb0200","doi-asserted-by":"crossref","first-page":"14430","DOI":"10.1073\/pnas.1322917111","article-title":"Platelet mechanosensing of substrate stiffness during clot formation mediates adhesion, spreading, and activation","volume":"111","author":"Qiu","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/jth.13863_bb0205","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.1182\/blood-2010-08-301523","article-title":"Coagulation\u2010induced shedding of platelet glycoprotein VI mediated by factor Xa","volume":"117","author":"Al\u2010Tamimi","year":"2011","journal-title":"Blood"},{"key":"10.1111\/jth.13863_bb0210","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1111\/j.1538-7836.2007.02590.x","article-title":"Controlled shedding of platelet glycoprotein (GP)VI and GPIb\u2010IX\u2010V by ADAM family metalloproteinases","volume":"5","author":"Gardiner","year":"2007","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1111\/jth.13863_bb0215","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1160\/TH03-12-0795","article-title":"GPVI down\u2010regulation in murine platelets through metalloproteinase\u2010dependent shedding","volume":"91","author":"Bergmeier","year":"2004","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.13863_bb0220","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1182\/blood-2004-07-2842","article-title":"Platelet activation induces metalloproteinase\u2010dependent GP VI cleavage to down\u2010regulate platelet reactivity to collagen","volume":"105","author":"Stephens","year":"2005","journal-title":"Blood"},{"key":"10.1111\/jth.13863_bb0225","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1021\/acs.biochem.5b01102","article-title":"A\u2010Disintegrin\u2010And\u2010Metalloproteinase (ADAM) 10 activity on resting and activated platelets","volume":"55","author":"Facey","year":"2016","journal-title":"Biochemistry"},{"key":"10.1111\/jth.13863_bb0230","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1182\/blood-2010-06-289108","article-title":"Differentially regulated GPVI ectodomain shedding by multiple platelet\u2010expressed proteinases","volume":"116","author":"Bender","year":"2010","journal-title":"Blood"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.13863","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622044154?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622044154?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/jth.13863\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:18:24Z","timestamp":1761535104000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622044154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":45,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S1538783622044154"],"URL":"https:\/\/doi.org\/10.1111\/jth.13863","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Soluble fibrin causes an acquired platelet glycoprotein VI signaling defect: implications for coagulopathy","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/jth.13863","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2017 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}