{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:22:27Z","timestamp":1762867347749,"version":"build-2065373602"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P27424","P23690","SFB\u2010F54"],"award-info":[{"award-number":["P27424","P23690","SFB\u2010F54"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1111\/jth.13971","type":"journal-article","created":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T03:52:42Z","timestamp":1518234762000},"page":"749-758","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Androgen receptor dampens tissue factor expression via nuclear factor\u2010\u03baB and early growth response protein 1"],"prefix":"10.1016","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7025-081X","authenticated-orcid":false,"given":"B.","family":"Hoesel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mussbacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Dikorman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Salzmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Assinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Hell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Thaler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bas\u00edlio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Moser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Resch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Paar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Mackman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1111\/jth.13971_bb0010","first-page":"7","article-title":"Cancer statistics, 2018","volume":"68","author":"Siegel","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"10.1111\/jth.13971_bb0015","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.urolonc.2008.04.001","article-title":"Outcomes for intermediate risk prostate cancer: are there advantages for surgery, external radiation, or brachytherapy?","volume":"27","author":"Klein","year":"2009","journal-title":"Urol Oncol"},{"key":"10.1111\/jth.13971_bb0020","first-page":"14","article-title":"Management of biochemically recurrent prostate cancer after local therapy: evolving standards of care and new directions","volume":"11","author":"Paller","year":"2013","journal-title":"Clin Adv Hematol Oncol"},{"key":"10.1111\/jth.13971_bb0025","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/j.ejca.2012.10.021","article-title":"Incidence of venous thromboembolism in patients with cancer \u2013 a cohort study using linked United Kingdom databases","volume":"49","author":"Walker","year":"2013","journal-title":"Eur J Cancer"},{"key":"10.1111\/jth.13971_bb0030","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S1470-2045(10)70038-3","article-title":"Risk of thromboembolic diseases in men with prostate cancer: results from the population\u2010based PCBaSe Sweden","volume":"11","author":"Van Hemelrijck","year":"2010","journal-title":"Lancet Oncol"},{"key":"10.1111\/jth.13971_bb0035","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.eururo.2015.06.022","article-title":"Androgen deprivation therapy for prostate cancer and the risk of venous thromboembolism","volume":"70","author":"Klil\u2010Drori","year":"2016","journal-title":"Eur Urol"},{"key":"10.1111\/jth.13971_bb0040","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.eururo.2012.01.045","article-title":"Androgen\u2010deprivation therapy for nonmetastatic prostate cancer is associated with an increased risk of peripheral arterial disease and venous thromboembolism","volume":"61","author":"Hu","year":"2012","journal-title":"Eur Urol"},{"key":"10.1111\/jth.13971_bb0045","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.1200\/JCO.2009.22.6324","article-title":"Role of tissue factor in cancer","volume":"27","author":"Kasthuri","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1111\/jth.13971_bb0050","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.thromres.2009.09.019","article-title":"Increased microparticle tissue factor activity in cancer patients with venous thromboembolism","volume":"125","author":"Manly","year":"2010","journal-title":"Thromb Res"},{"key":"10.1111\/jth.13971_bb0055","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1538-7836.2007.02369.x","article-title":"Microparticle\u2010associated tissue factor activity: a link between cancer and thrombosis?","volume":"5","author":"Tesselaar","year":"2007","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.13971_bb0060","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/S0090-4295(03)00768-4","article-title":"Tissue factor expression and prognosis in patients with metastatic prostate cancer","volume":"62","author":"Akashi","year":"2003","journal-title":"Urology"},{"key":"10.1111\/jth.13971_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.pai.0000213157.94804.fc","article-title":"Expression of tissue factor in prostate cancer correlates with malignant phenotype","volume":"16","author":"Kaushal","year":"2008","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1111\/jth.13971_bb0070","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1053\/hp.2000.6547","article-title":"Tissue factor expression and angiogenesis in human prostate carcinoma","volume":"31","author":"Abdulkadir","year":"2000","journal-title":"Hum Pathol"},{"key":"10.1111\/jth.13971_bb0075","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1080\/07357900802527247","article-title":"Tissue factor and VEGF expression in prostate carcinoma: a tissue microarray study","volume":"27","author":"Yao","year":"2009","journal-title":"Cancer Invest"},{"key":"10.1111\/jth.13971_bb0080","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1096\/fasebj.9.10.7615158","article-title":"Regulation of the tissue factor gene","volume":"9","author":"Mackman","year":"1995","journal-title":"FASEB J"},{"key":"10.1111\/jth.13971_bb0085","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/01.ATV.17.2.365","article-title":"Regulation of the tissue factor gene in human monocytic cells. Role of AP\u20101, NF\u2010kappa B\/Rel, and Sp1 proteins in uninduced and lipopolysaccharide\u2010induced expression","volume":"17","author":"Oeth","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/jth.13971_bb0090","doi-asserted-by":"crossref","first-page":"e12683","DOI":"10.1371\/journal.pone.0012683","article-title":"Interaction of the TNFR\u2010receptor associated factor TRAF1 with I\u2010kappa B kinase\u20102 and TRAF2 indicates a regulatory function for NF\u2010kappa B signaling","volume":"5","author":"Sughra","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1111\/jth.13971_bb0095","doi-asserted-by":"crossref","first-page":"11204","DOI":"10.1074\/jbc.M008207200","article-title":"Hormone status selects for spontaneous somatic androgen receptor variants that demonstrate specific ligand and cofactor dependent activities in autochthonous prostate cancer","volume":"276","author":"Han","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.13971_bb0100","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bbamcr.2015.10.023","article-title":"Sequence\u2013function correlations and dynamics of ERG isoforms. ERG8 is the black sheep of the family","volume":"1863","author":"Hoesel","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.1111\/jth.13971_bb0105","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/gkp045","article-title":"Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data","volume":"37","author":"Ruijter","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1111\/jth.13971_bb0110","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1101\/gad.364306","article-title":"Acetylation of Stat1 modulates NF\u2010kappaB activity","volume":"20","author":"Kr\u00e4mer","year":"2006","journal-title":"Genes Dev"},{"key":"10.1111\/jth.13971_bb0115","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1111\/j.1538-7836.2009.03448.x","article-title":"Levels of microparticle tissue factor activity correlate with coagulation activation in endotoxemic mice","volume":"7","author":"Wang","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.13971_bb0120","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge\u2010based approach for interpreting genome\u2010wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/jth.13971_bb0125","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.ccr.2011.05.006","article-title":"Cell autonomous role of PTEN in regulating castration\u2010resistant prostate cancer growth","volume":"19","author":"Mulholland","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1111\/jth.13971_bb0130","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ccr.2010.05.026","article-title":"Integrative genomic profiling of human prostate cancer","volume":"18","author":"Taylor","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1111\/jth.13971_bb0135","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1002\/pros.22841","article-title":"Dihydrotestosterone enhances castration\u2010resistant prostate cancer cell proliferation through STAT5 activation via glucocorticoid receptor pathway","volume":"74","author":"Song","year":"2014","journal-title":"Prostate"},{"key":"10.1111\/jth.13971_bb0140","first-page":"7106","article-title":"Interruption of nuclear factor kappaB signaling by the androgen receptor facilitates 12\u2010O\u2010tetradecanoylphorbolacetate\u2010induced apoptosis in androgen\u2010sensitive prostate cancer LNCaP cells","volume":"63","author":"Altuwaijri","year":"2003","journal-title":"Cancer Res"},{"key":"10.1111\/jth.13971_bb0145","doi-asserted-by":"crossref","first-page":"26267","DOI":"10.1074\/jbc.271.42.26267","article-title":"Inhibition of NFkappaB activity through maintenance of IkappaBalpha levels contributes to dihydrotestosterone\u2010mediated repression of the interleukin\u20106 promoter","volume":"271","author":"Keller","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.13971_bb0150","first-page":"2461","article-title":"Expression of early growth response genes in human prostate cancer","volume":"58","author":"Eid","year":"1998","journal-title":"Cancer Res"},{"key":"10.1111\/jth.13971_bb0155","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/83231","article-title":"Impaired prostate tumorigenesis in Egr1\u2010deficient mice","volume":"7","author":"Abdulkadir","year":"2001","journal-title":"Nat Med"},{"key":"10.1111\/jth.13971_bb0160","first-page":"2883","article-title":"Androgen deprivation therapy induces androgen receptor\u2010dependent upregulation of Egr1 in prostate cancers","volume":"7","author":"Xu","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1111\/jth.13971_bb0165","doi-asserted-by":"crossref","first-page":"8173","DOI":"10.18632\/oncotarget.2303","article-title":"A screen for transcription factor targets of glycogen synthase kinase\u20103 highlights an inverse correlation of NF\u03baB and androgen receptor signaling in prostate cancer","volume":"5","author":"Campa","year":"2014","journal-title":"Oncotarget"},{"key":"10.1111\/jth.13971_bb0170","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/ijc.22802","article-title":"Androgen receptor targets NFkappaB and TSP1 to suppress prostate tumor growth in vivo","volume":"121","author":"Nelius","year":"2007","journal-title":"Int J Cancer"},{"key":"10.1111\/jth.13971_bb0175","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/sj.bjc.6602851","article-title":"Activation of nuclear factor\u2010kappaB in human prostate carcinogenesis and association to biochemical relapse","volume":"93","author":"Domingo\u2010Domenech","year":"2005","journal-title":"Br J Cancer"},{"key":"10.1111\/jth.13971_bb0180","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1038\/bjc.2012.372","article-title":"NF\u03baB signalling is upregulated in a subset of castrate\u2010resistant prostate cancer patients and correlates with disease progression","volume":"107","author":"McCall","year":"2012","journal-title":"Br J Cancer"},{"key":"10.1111\/jth.13971_bb0185","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1158\/1078-0432.CCR-0543-3","article-title":"Expression of nuclear factor\u2010kappa B and I kappa B alpha proteins in prostatic adenocarcinomas: correlation of nuclear factor\u2010kappa B immunoreactivity with disease recurrence","volume":"10","author":"Ross","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1111\/jth.13971_bb0190","doi-asserted-by":"crossref","first-page":"E263","DOI":"10.5489\/cuaj.471","article-title":"Defining a new testosterone threshold for medical castration: results from a prospective cohort series","volume":"7","author":"Dason","year":"2013","journal-title":"Can Urol Assoc J"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.13971","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.13971","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jth.13971","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622009667?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622009667?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.13971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:21:40Z","timestamp":1761535300000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622009667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S1538783622009667"],"URL":"https:\/\/doi.org\/10.1111\/jth.13971","relation":{},"ISSN":["1538-7836"],"issn-type":[{"type":"print","value":"1538-7836"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Androgen receptor dampens tissue factor expression via nuclear factor\u2010\u03baB and early growth response protein 1","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/jth.13971","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2018 The Authors. Journal of Thrombosis and Haemostasis. Published by ELSEVIER INC. on behalf of International Society on Thrombosis and Haemostasis","name":"copyright","label":"Copyright"}]}}