{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:43:51Z","timestamp":1790837031415,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":1408,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL077193"],"award-info":[{"award-number":["HL077193"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL112303"],"award-info":[{"award-number":["HL112303"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1111\/jth.14337","type":"journal-article","created":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T09:41:14Z","timestamp":1542620474000},"page":"149-156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Suppressing protein Z\u2010dependent inhibition of factor Xa improves coagulation in hemophilia A"],"prefix":"10.1016","volume":"17","author":[{"given":"T.J.","family":"Girard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.M.","family":"Lasky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Grunz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"G.J.","family":"Broze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/jth.14337_bb0010","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/jth.12864","article-title":"Safety and pharmacokinetics of anti\u2010TFPI antibody (concizumab) in healthy volunteers and patients with hemophilia: a randomized first human dose trial","volume":"13","author":"Chowdary","year":"2015","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14337_bb0015","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/nm.3847","article-title":"An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia","volume":"21","author":"Sehgal","year":"2015","journal-title":"Nat Med"},{"key":"10.1111\/jth.14337_bb0020","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1182\/blood-2016-05-718635","article-title":"Design and characterization of an APC\u2010specific serpin for the treatment of hemophilia","volume":"129","author":"Polderdijk","year":"2017","journal-title":"Blood"},{"key":"10.1111\/jth.14337_bb0025","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1182\/blood-2017-09-800326","article-title":"Targeting anticoagulant protein S to improve hemostasis in hemophilia","volume":"131","author":"Prince","year":"2018","journal-title":"Blood"},{"key":"10.1111\/jth.14337_bb0030","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1172\/JCI111317","article-title":"Human protein Z","volume":"73","author":"Broze","year":"1984","journal-title":"J Clin Invest"},{"key":"10.1111\/jth.14337_bb0035","doi-asserted-by":"crossref","first-page":"29770","DOI":"10.1074\/jbc.M805214200","article-title":"Kinetic characterization of the protein Z\u2010dependent protease inhibitor reaction with blood coagulation factor Xa","volume":"283","author":"Huang","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.14337_bb0040","doi-asserted-by":"crossref","first-page":"9250","DOI":"10.1073\/pnas.95.16.9250","article-title":"Isolation of a protein Z\u2010dependent plasma protease inhibitor","volume":"95","author":"Han","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/jth.14337_bb0045","doi-asserted-by":"crossref","first-page":"11073","DOI":"10.1021\/bi990641a","article-title":"The protein Z\u2010dependent protease inhibitor is a serpin","volume":"38","author":"Han","year":"1999","journal-title":"Biochemistry"},{"key":"10.1111\/jth.14337_bb0050","doi-asserted-by":"crossref","first-page":"19922","DOI":"10.1074\/jbc.M802639200","article-title":"Protein Z\u2010dependent protease inhibitor binds to the C\u2010terminal domain of protein Z","volume":"283","author":"Rezaie","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.14337_bb0055","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1182\/blood-2009-04-210021","article-title":"Crystal structure of protein Z\u2010dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X","volume":"114","author":"Wei","year":"2009","journal-title":"Blood"},{"key":"10.1111\/jth.14337_bb0060","doi-asserted-by":"crossref","first-page":"20399","DOI":"10.1074\/jbc.M110.112748","article-title":"Basis for the specificity and activation of the serpin protein Z\u2010dependent proteinase inhibitor (ZPI) as an inhibitor of membrane\u2010associated factor Xa","volume":"285","author":"Huang","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.14337_bb0065","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1182\/blood.V96.9.3049","article-title":"Characterization of the protein Z\u2010dependent protease inhibitor","volume":"96","author":"Han","year":"2000","journal-title":"Blood"},{"key":"10.1111\/jth.14337_bb0070","doi-asserted-by":"crossref","first-page":"9427","DOI":"10.1021\/bi060820+","article-title":"Contributions of basic amino acids in the autolysis loop of factor XIa to serpin specificity","volume":"45","author":"Rezaie","year":"2006","journal-title":"Biochemistry"},{"key":"10.1111\/jth.14337_bb0075","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1160\/TH04-11-0715","article-title":"Protein Z and protein Z\u2010dependent protease inhibitor: determinants of levels and risk of venous thrombosis","volume":"93","author":"Al\u2010Shanqeeti","year":"2005","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.14337_bb0080","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1055\/s-0037-1615649","article-title":"Protein Z circulates in plasma in a complex with protein Z\u2010dependent protease inhibitor","volume":"85","author":"Tabatabai","year":"2001","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.14337_bb0085","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1111\/j.1538-7836.2006.02012.x","article-title":"Protein Z and ZPI levels and cardiovascular events","volume":"4","author":"Refaai","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14337_bb0090","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1365-2141.2007.06548.x","article-title":"Protein Z\/Z\u2010dependent protease inhibitor (PZ\/ZPI) anticoagulant system and thrombosis","volume":"137","author":"Corral","year":"2007","journal-title":"Br J Haematol"},{"key":"10.1111\/jth.14337_bb0095","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s11936-007-0012-7","article-title":"Role of protein Z in stroke","volume":"9","author":"Tran","year":"2007","journal-title":"Curr Treat Options Cardiovasc Med"},{"key":"10.1111\/jth.14337_bb0100","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.thromres.2011.08.007","article-title":"The risk of occurrence of venous thrombosis: focus on protein Z","volume":"128","author":"Bafunno","year":"2011","journal-title":"Thromb Res"},{"key":"10.1111\/jth.14337_bb0105","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1182\/blood.V90.3.944","article-title":"Tissue factor pathway inhibitor gene disruption produces intrauterine lethality in mice","volume":"90","author":"Huang","year":"1997","journal-title":"Blood"},{"key":"10.1111\/jth.14337_bb0110","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1172\/JCI10489","article-title":"Complete antithrombin deficiency in mice results in embryonic lethality","volume":"106","author":"Ishiguro","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1111\/jth.14337_bb0115","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1172\/JCI3011","article-title":"Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice","volume":"102","author":"Jalbert","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1111\/jth.14337_bb0120","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1172\/JCI39325","article-title":"Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis","volume":"119","author":"Burstyn\u2010Cohen","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1111\/jth.14337_bb0125","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1182\/blood-2009-03-209031","article-title":"Generation and phenotypic analysis of protein S\u2010deficient mice","volume":"114","author":"Saller","year":"2009","journal-title":"Blood"},{"key":"10.1111\/jth.14337_bb0130","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1073\/pnas.1119858109","article-title":"Absence of hematopoietic tissue factor pathway inhibitor mitigates bleeding in mice with hemophilia","volume":"109","author":"Maroney","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/jth.14337_bb0135","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1160\/TH09-10-0732","article-title":"Heterozygous antithrombin deficiency improves in vivo haemostasis in factor VIII\u2010deficient mice","volume":"103","author":"Bolliger","year":"2010","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.14337_bb0140","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.1073\/pnas.120081897","article-title":"Prothrombotic phenotype of protein Z deficiency","volume":"97","author":"Yin","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/jth.14337_bb0145","doi-asserted-by":"crossref","first-page":"4973","DOI":"10.1182\/blood-2007-12-126391","article-title":"Protein Z\u2010dependent protease inhibitor deficiency produces a more severe phenotype than protein Z deficiency","volume":"111","author":"Zhang","year":"2008","journal-title":"Blood"},{"key":"10.1111\/jth.14337_bb0150","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1182\/blood-2012-03-419598","article-title":"Structural basis for catalytic activation of protein Z\u2010dependent protease inhibitor (ZPI) by protein Z","volume":"120","author":"Huang","year":"2012","journal-title":"Blood"},{"key":"10.1111\/jth.14337_bb0155","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.thromres.2012.10.011","article-title":"Data management in thrombin generation","volume":"131","author":"Hemker","year":"2013","journal-title":"Thromb Res"},{"key":"10.1111\/jth.14337_bb0160","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1111\/jth.12700","article-title":"Influence of genetic background on bleeding phenotype in the tail\u2010tip bleeding model and recommendations for standardization: communication from the SSC of the ISTH","volume":"12","author":"Schiviz","year":"2014","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14337_bb0165","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1055\/s-0037-1615666","article-title":"A tail vein bleeding time model and delayed bleeding in hemophiliac mice","volume":"85","author":"Broze","year":"2001","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.14337_bb0170","doi-asserted-by":"crossref","first-page":"6774","DOI":"10.3390\/md13116774","article-title":"The marine\u2010derived kinase inhibitor fascaplysin exerts anti\u2010thrombotic activity","volume":"13","author":"Ampofo","year":"2015","journal-title":"Mar Drugs"},{"key":"10.1111\/jth.14337_bb0175","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1161\/STROKEAHA.111.624650","article-title":"Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran","volume":"42","author":"Zhou","year":"2011","journal-title":"Stroke"},{"key":"10.1111\/jth.14337_bb0180","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1182\/blood-2007-05-090944","article-title":"Vascular smooth muscle\u2010derived tissue factor is critical for arterial thrombosis after ferric chloride\u2010induced injury","volume":"113","author":"Wang","year":"2009","journal-title":"Blood"},{"key":"10.1111\/jth.14337_bb0185","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1182\/blood-2011-08-367813","article-title":"Prolonged activity of a recombinant factor VIII\u2010Fc fusion protein in hemophilia A mice and dogs","volume":"119","author":"Dumont","year":"2012","journal-title":"Blood"},{"key":"10.1111\/jth.14337_bb0190","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1182\/blood-2009-03-212423","article-title":"Enhanced efficacy of recombinant FVIII in noncovalent complex with PEGylated liposome in hemophilia A mice","volume":"114","author":"Pan","year":"2009","journal-title":"Blood"},{"key":"10.1111\/jth.14337_bb0195","doi-asserted-by":"crossref","first-page":"e113600","DOI":"10.1371\/journal.pone.0113600","article-title":"A single chain variant of factor VIII\u2010Fc fusion protein retains normal in vivo efficacy but exhibits altered in vitro activity","volume":"9","author":"Buyue","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1111\/jth.14337_bb0200","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/hae.12907","article-title":"Development of a tail vein transection bleeding model in fully anaesthetized haemophilia A mice \u2013 characterization of two novel FVIII molecules","volume":"22","author":"Johansen","year":"2016","journal-title":"Haemophilia"},{"key":"10.1111\/jth.14337_bb0205","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1182\/blood-2008-01-136820","article-title":"The heparin\u2010binding exosite of factor IXa is a critical regulator of plasma thrombin generation and venous thrombosis","volume":"112","author":"Buyue","year":"2008","journal-title":"Blood"},{"key":"10.1111\/jth.14337_bb0210","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/j.1365-2516.2012.02780.x","article-title":"A sensitive venous bleeding model in haemophilia A mice: effects of two recombinant FVIII products (N8 and Advate)","volume":"18","author":"Pastoft","year":"2012","journal-title":"Haemophilia"},{"key":"10.1111\/jth.14337_bb0215","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1160\/TH04-10-0706","article-title":"Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B","volume":"93","author":"Dargaud","year":"2005","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.14337_bb0220","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1365-2516.2005.01107.x","article-title":"Thrombin generation and phenotype correlation in haemophilia A","volume":"11","author":"Beltran\u2010Miranda","year":"2005","journal-title":"Haemophilia"},{"key":"10.1111\/jth.14337_bb0225","doi-asserted-by":"crossref","first-page":"5120","DOI":"10.1021\/bi9626160","article-title":"Comparison of naturally occurring vitamin K\u2010dependent proteins: correlation of amino acid sequences and membrane binding properties suggests a membrane contact site","volume":"36","author":"McDonald","year":"1997","journal-title":"Biochemistry"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.14337","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.14337","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jth.14337","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622030355?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622030355?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.14337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:25:25Z","timestamp":1761535525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622030355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S1538783622030355"],"URL":"https:\/\/doi.org\/10.1111\/jth.14337","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Suppressing protein Z\u2010dependent inhibition of factor Xa improves coagulation in hemophilia A","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/jth.14337","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2018 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}