{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:32:46Z","timestamp":1791657166709,"version":"4.3.4"},"reference-count":100,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":1377,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["8010002"],"award-info":[{"award-number":["8010002"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1060637"],"award-info":[{"award-number":["1060637"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1090170"],"award-info":[{"award-number":["1090170"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1111\/jth.14363","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T10:59:17Z","timestamp":1545130757000},"page":"257-270","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["Diagnostic challenges of inherited mild bleeding disorders: a bait for poorly explored clinical and basic research"],"prefix":"10.1016","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2448-9288","authenticated-orcid":false,"given":"D.","family":"Mezzano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Quiroga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/jth.14363_bb0010","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1111\/jth.13368","article-title":"A diagnostic approach to mild bleeding disorders","volume":"14","author":"Boender","year":"2016","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0015","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3324\/haematol.10816","article-title":"High prevalence of bleeders of unknown cause among patients with inherited mucocutaneous bleeding. A prospective study of 280 patients and 299 controls","volume":"92","author":"Quiroga","year":"2007","journal-title":"Haematologica"},{"key":"10.1111\/jth.14363_bb0020","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/hae.13422","article-title":"High proportion of patients with bleeding of unknown cause in persons with a mild\u2010to\u2010moderate bleeding tendency: results from the Vienna Bleeding Biobank (VIBB)","volume":"24","author":"Gebhart","year":"2018","journal-title":"Haemophilia"},{"key":"10.1111\/jth.14363_bb0025","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1111\/j.1538-7836.2004.00933.x","article-title":"Slippery criteria for von Willebrand disease type\u00a01","volume":"2","author":"Sadler","year":"2004","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0030","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1538-7836.2010.04105.x","article-title":"Impact of sex, age, race, ethnicity and aspirin use on bleeding symptoms in healthy adults","volume":"9","author":"Mauer","year":"2011","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0035","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1111\/j.1538-7836.2005.01663.x","article-title":"The discriminant power of bleeding history for the diagnosis of type\u00a01 von Willebrand disease: an international, multicenter study","volume":"3","author":"Rodeghiero","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0040","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1538-7836.2009.03661.x","article-title":"The prevalence of symptomatic von Willebrand disease in primary care practice","volume":"8","author":"Bowman","year":"2010","journal-title":"J Thromb Haemost"},{"issue":"Suppl. 1","key":"10.1111\/jth.14363_bb0045","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1016\/S0049-3848(17)30072-5","article-title":"Heavy menstrual bleeding: an update on management","volume":"151","author":"Davies","year":"2017","journal-title":"Thromb Res"},{"key":"10.1111\/jth.14363_bb0050","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1046\/j.1538-7836.2003.00061.x","article-title":"Platelet functional defects in women with unexplained menorrhagia","volume":"1","author":"Philipp","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0055","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/j.1471-0528.2004.00176.x","article-title":"von Willebrand disease in women with menorrhagia: a systematic review","volume":"111","author":"Shankar","year":"2004","journal-title":"BJOG"},{"key":"10.1111\/jth.14363_bb0060","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.ijporl.2012.02.033","article-title":"Predictors of bleeding disorders in children with epistaxis: value of preoperative tests and clinical screening","volume":"76","author":"Elden","year":"2012","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"10.1111\/jth.14363_bb0065","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/00043426-200201000-00013","article-title":"Clinical and laboratory features of 178 children with recurrent epistaxis","volume":"24","author":"Sandoval","year":"2002","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1111\/jth.14363_bb0070","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1001\/archinte.1995.00430130095010","article-title":"Usefulness of patient interview in bleeding disorders","volume":"155","author":"Sramek","year":"1995","journal-title":"Arch Intern Med"},{"key":"10.1111\/jth.14363_bb0075","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1182\/blood-2015-10-673681","article-title":"Clinical and laboratory variability in a cohort of patients diagnosed with type\u00a01 VWD in the United States","volume":"127","author":"Flood","year":"2016","journal-title":"Blood"},{"key":"10.1111\/jth.14363_bb0080","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1111\/j.1538-7836.2005.01681.x","article-title":"von Willebrand disease \u2013 the relevance of history","volume":"3","author":"Montgomery","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0085","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1182\/asheducation.V2012.1.152.3798226","article-title":"Bleeding scores: are they really useful?","volume":"2012","author":"O'Brien","year":"2012","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1111\/jth.14363_bb0090","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1055\/s-0028-1104544","article-title":"Laboratory assessment of familial, nonthrombocytopenic mucocutaneous bleeding: a definitive diagnosis is often not possible","volume":"34","author":"Pereira","year":"2008","journal-title":"Semin Thromb Hemost"},{"key":"10.1111\/jth.14363_bb0095","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1111\/j.1538-7836.2010.03975.x","article-title":"ISTH\/SSC bleeding assessment tool: a standardized questionnaire and a proposal for a new bleeding score for inherited bleeding disorders","volume":"8","author":"Rodeghiero","year":"2010","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0100","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/hae.12503","article-title":"Normal range of bleeding scores for the ISTH\u2010BAT: adult and pediatric data from the merging project","volume":"20","author":"Elbatarny","year":"2014","journal-title":"Haemophilia"},{"key":"10.1111\/jth.14363_bb0105","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1111\/j.1538-7836.2009.03499.x","article-title":"Evaluation of the diagnostic utility for von Willebrand disease of a pediatric bleeding questionnaire","volume":"7","author":"Bowman","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0110","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1365-2516.2010.02390.x","article-title":"The power of a standardized bleeding score in diagnosing paediatric type\u00a01 von Willebrand's disease and platelet function defects","volume":"17","author":"Marcus","year":"2011","journal-title":"Haemophilia"},{"key":"10.1111\/jth.14363_bb0115","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1111\/j.1538-7836.2012.04775.x","article-title":"Prospective evaluation of a pediatric bleeding questionnaire and the ISTH bleeding assessment tool in children and parents in routine clinical practice","volume":"10","author":"Bidlingmaier","year":"2012","journal-title":"J Thromb Haemost"},{"issue":"Suppl. 1","key":"10.1111\/jth.14363_bb0120","first-page":"S45","article-title":"Approaches to investigating common bleeding disorders: an evaluation of North American coagulation laboratory practices","volume":"87","author":"Hayward","year":"2012","journal-title":"Am J Hematol"},{"key":"10.1111\/jth.14363_bb0125","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1093\/clinchem\/47.7.1204","article-title":"Discontinuation of the bleeding time test without detectable adverse clinical impact","volume":"47","author":"Lehman","year":"2001","journal-title":"Clin Chem"},{"key":"10.1111\/jth.14363_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-2007-1002658","article-title":"A critical reappraisal of the bleeding time","volume":"16","author":"Rodgers","year":"1990","journal-title":"Semin Thromb Hemost"},{"key":"10.1111\/jth.14363_bb0135","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1182\/blood.V77.12.2547.2547","article-title":"The bleeding time does not predict surgical bleeding","volume":"77","author":"Lind","year":"1991","journal-title":"Blood"},{"key":"10.1111\/jth.14363_bb0140","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1111\/j.1538-7836.2004.00693.x","article-title":"Template bleeding time and PFA\u2010100 have low sensitivity to screen patients with hereditary mucocutaneous hemorrhages: comparative study in 148 patients","volume":"2","author":"Quiroga","year":"2004","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0145","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1111\/j.1538-7836.2007.02752.x","article-title":"Usefulness of PFA\u2010100 testing in the diagnostic screening of patients with suspected abnormalities of hemostasis: comparison with the bleeding time","volume":"5","author":"Podda","year":"2007","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0150","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/ajh.24620","article-title":"Clinical utility of closure times using the platelet function analyzer\u2010100\/200","volume":"92","author":"Favaloro","year":"2017","journal-title":"Am J Hematol"},{"key":"10.1111\/jth.14363_bb0155","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1365-2516.2007.01643.x","article-title":"von Willebrand disease (VWD): evidence\u2010based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel\u00a0report (USA)","volume":"14","author":"Nichols","year":"2008","journal-title":"Haemophilia"},{"key":"10.1111\/jth.14363_bb0160","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1538-7836.2006.01771.x","article-title":"Platelet function analyzer (PFA)\u2010100 closure time in the evaluation of platelet disorders and platelet function","volume":"4","author":"Hayward","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0165","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1538-7836.2012.04653.x","article-title":"Coagulation factor activity and clinical bleeding severity in rare bleeding disorders: results from the European Network of Rare Bleeding Disorders","volume":"10","author":"Peyvandi","year":"2012","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0170","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1182\/blood.V98.2.257","article-title":"Platelets from patients with the Quebec platelet disorder contain and secrete abnormal amounts of urokinase\u2010type plasminogen activator","volume":"98","author":"Kahr","year":"2001","journal-title":"Blood"},{"key":"10.1111\/jth.14363_bb0175","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1538-7836.2005.01114.x","article-title":"Bleeding and thrombotic problems in a patient with alpha2 plasmin inhibitor deficiency","volume":"3","author":"Hayward","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0180","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1182\/blood.V90.1.204.204_204_208","article-title":"Human plasminogen activator inhibitor\u20101 (PAI\u20101) deficiency: characterization of a large kindred with a null mutation in the PAI\u20101 gene","volume":"90","author":"Fay","year":"1997","journal-title":"Blood"},{"key":"10.1111\/jth.14363_bb0185","first-page":"152","article-title":"Determination of the von Willebrand's disease antigen (factor\u00a0VIII\u2010related antigen) in plasma by quantitative immunoelectrophoresis","volume":"86","author":"Zimmerman","year":"1975","journal-title":"J Lab Clin Med"},{"key":"10.1111\/jth.14363_bb0190","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1182\/blood.V41.5.687.687","article-title":"Ristocetin: a means of differentiating von Willebrand's disease into two groups","volume":"41","author":"Howard","year":"1973","journal-title":"Blood"},{"key":"10.1111\/jth.14363_bb0195","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1182\/blood-2011-10-384610","article-title":"VWF mutations and new sequence variations identified in healthy controls are more frequent in the African\u2010American population","volume":"119","author":"Bellissimo","year":"2012","journal-title":"Blood"},{"key":"10.1111\/jth.14363_bb0200","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1182\/blood-2017-05-786699","article-title":"Novel insights into the clinical phenotype and pathophysiology underlying low VWF levels","volume":"130","author":"Lavin","year":"2017","journal-title":"Blood"},{"key":"10.1111\/jth.14363_bb0205","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1182\/asheducation-2013.1.254","article-title":"Willebrand disease: advances in pathogenetic understanding, diagnosis, and therapy","volume":"2013","author":"von Lillicrap","year":"2013","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1111\/jth.14363_bb0210","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1160\/TH-07-12-0757","article-title":"Major haemorrhage related to surgery in patients with type\u00a01 and possible type\u00a01 von Willebrand disease","volume":"100","author":"Woods","year":"2008","journal-title":"Thromb Haemost"},{"issue":"Suppl. 1","key":"10.1111\/jth.14363_bb0215","first-page":"S4","article-title":"von Willebrand disease: clinical and laboratory lessons learned from the large von Willebrand disease studies","volume":"87","author":"James","year":"2012","journal-title":"Am J Hematol"},{"key":"10.1111\/jth.14363_bb0220","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1182\/blood.V69.6.1691.1691","article-title":"The effect of ABO blood group on the diagnosis of von Willebrand disease","volume":"69","author":"Gill","year":"1987","journal-title":"Blood"},{"key":"10.1111\/jth.14363_bb0225","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1111\/jth.12964","article-title":"Platelet\u2010dependent von Willebrand factor activity. Nomenclature and methodology: communication from the SSC of the ISTH","volume":"13","author":"Bodo","year":"2015","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0230","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1111\/jth.14319","article-title":"Clinically relevant differences between assays for von Willebrand factor activity","volume":"16","author":"Boender","year":"2018","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0235","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1182\/blood-2009-10-249102","article-title":"Common VWF exon\u00a028 polymorphisms in African Americans affecting the VWF activity assay by ristocetin cofactor","volume":"116","author":"Flood","year":"2010","journal-title":"Blood"},{"key":"10.1111\/jth.14363_bb0240","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1182\/blood-2014-11-610824","article-title":"Crucial role for the VWF A1 domain in binding to type\u00a0IV collagen","volume":"125","author":"Flood","year":"2015","journal-title":"Blood"},{"key":"10.1111\/jth.14363_bb0245","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1182\/blood-2006-05-020784","article-title":"Phenotype and genotype of a cohort of families historically diagnosed with type\u00a01 von Willebrand disease in the European study, Molecular and Clinical Markers for the Diagnosis and Management of Type\u00a01 von Willebrand Disease (MCMDM\u20101VWD)","volume":"109","author":"Goodeve","year":"2007","journal-title":"Blood"},{"key":"10.1111\/jth.14363_bb0250","doi-asserted-by":"crossref","first-page":"667","DOI":"10.3324\/haematol.2012.077263","article-title":"Principles of care for the diagnosis and treatment of von Willebrand disease","volume":"98","author":"Castaman","year":"2013","journal-title":"Haematologica"},{"key":"10.1111\/jth.14363_bb0255","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/bjh.13064","article-title":"The diagnosis and management of von Willebrand disease: a United Kingdom Haemophilia Centre Doctors Organization guideline approved by the British Committee for Standards in Haematology","volume":"167","author":"Laffan","year":"2014","journal-title":"Br J Haematol"},{"key":"10.1111\/jth.14363_bb0260","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1538-7836.2006.01860.x","article-title":"Genetic linkage and association analysis in type\u00a01 von Willebrand disease: results from the Canadian type\u00a01 VWD study","volume":"4","author":"James","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0265","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1182\/blood-2017-09-807180","article-title":"Low VWF: an established mild bleeding disorder?","volume":"130","author":"Leebeek","year":"2017","journal-title":"Blood"},{"key":"10.1111\/jth.14363_bb0270","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.thromres.2017.09.025","article-title":"von Willebrand disease mutation spectrum and associated mutation mechanisms","volume":"159","author":"de Jong","year":"2017","journal-title":"Thromb Res"},{"key":"10.1111\/jth.14363_bb0275","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1182\/asheducation-2016.1.678","article-title":"Diagnosing von Willebrand disease: genetic analysis","volume":"2016","author":"Goodeve","year":"2016","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1111\/jth.14363_bb0280","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1111\/jth.12594","article-title":"Quantitative impact of using different criteria for the laboratory diagnosis of type\u00a01 von Willebrand disease","volume":"12","author":"Quiroga","year":"2014","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0285","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/ejhg.2015.222","article-title":"Genome\u2010wide association studies identify genetic loci for low von Willebrand factor levels","volume":"24","author":"van Loon","year":"2016","journal-title":"Eur J Hum Genet"},{"key":"10.1111\/jth.14363_bb0290","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1182\/blood-2007-11-122945","article-title":"A shorter von Willebrand factor survival in O blood group subjects explains how ABO determinants influence plasma von Willebrand factor","volume":"111","author":"Gallinaro","year":"2008","journal-title":"Blood"},{"key":"10.1111\/jth.14363_bb0295","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/bjh.15565","article-title":"von Willebrand factor clearance \u2013 biological mechanisms and clinical significance","volume":"183","author":"O'Sullivan","year":"2018","journal-title":"Br J Haematol"},{"key":"10.1111\/jth.14363_bb0300","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1182\/blood-2006-06-032706","article-title":"Variations in glycosylation of von Willebrand factor with O\u2010linked sialylated T antigen are associated with its plasma levels","volume":"109","author":"van Schooten","year":"2007","journal-title":"Blood"},{"key":"10.1111\/jth.14363_bb0305","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/jth.12885","article-title":"Shear stress\u2010independent binding of von Willebrand factor\u2010type\u00a02B mutants p.R1306Q & p.V1316M to LRP1 explains their increased clearance","volume":"13","author":"Wohner","year":"2015","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0310","doi-asserted-by":"crossref","first-page":"728","DOI":"10.3324\/haematol.2017.175216","article-title":"Macrophage scavenger receptor SR\u2010AI contributes to the clearance of von Willebrand factor","volume":"103","author":"Wohner","year":"2018","journal-title":"Haematologica"},{"key":"10.1111\/jth.14363_bb0315","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1055\/s-0031-1281039","article-title":"von Willebrand disease in the United States: a perspective from Wisconsin","volume":"37","author":"Flood","year":"2011","journal-title":"Semin Thromb Hemost"},{"key":"10.1111\/jth.14363_bb0320","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1182\/blood-2014-09-603241","article-title":"von Willebrand factor propeptide and the phenotypic classification of von Willebrand disease","volume":"125","author":"Sanders","year":"2015","journal-title":"Blood"},{"key":"10.1111\/jth.14363_bb0325","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1111\/jth.12231","article-title":"Recommendations for the standardization of light transmission aggregometry: a consensus of the working party from the platelet physiology subcommittee of SSC\/ISTH","volume":"11","author":"Cattaneo","year":"2013","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0330","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/jth.12792","article-title":"Diagnosis of inherited platelet function disorders: guidance from the SSC of the ISTH","volume":"13","author":"Gresele","year":"2015","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0335","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1309\/AJCP9V3RRVNZMKDS","article-title":"Development of North American consensus guidelines for medical laboratories that perform and interpret platelet function testing using light transmission aggregometry","volume":"134","author":"Hayward","year":"2010","journal-title":"Am J Clin Pathol"},{"key":"10.1111\/jth.14363_bb0340","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1538-7836.2009.03273.x","article-title":"Diagnostic utility of light transmission platelet aggregometry: results from a prospective study of individuals referred for bleeding disorder assessments","volume":"7","author":"Hayward","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0345","first-page":"134","article-title":"An evaluation of methods for determining reference intervals for light transmission platelet aggregation tests on samples with normal or reduced platelet counts","volume":"100","author":"Hayward","year":"2008","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0350","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/j.1365-2141.2009.07890.x","article-title":"Diagnosis of mild platelet function disorders. Reliability and usefulness of light transmission platelet aggregation and serotonin secretion assays","volume":"147","author":"Quiroga","year":"2009","journal-title":"Br J Haematol"},{"key":"10.1111\/jth.14363_bb0355","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1111\/jth.12650","article-title":"Diagnosis of suspected inherited platelet function disorders: results of a worldwide survey","volume":"12","author":"Gresele","year":"2014","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0360","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s00277-006-0244-8","article-title":"Spectrum of von Willebrand disease and inherited platelet function disorders amongst Indian bleeders","volume":"86","author":"Gupta","year":"2007","journal-title":"Ann Hematol"},{"key":"10.1111\/jth.14363_bb0365","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1182\/blood.V70.3.620.620","article-title":"Patients with a prolonged bleeding time and normal aggregation tests may have storage pool deficiency: studies on one hundred six patients","volume":"70","author":"Nieuwenhuis","year":"1987","journal-title":"Blood"},{"key":"10.1111\/jth.14363_bb0370","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1365-2141.1990.00118.x","article-title":"Platelet storage pool deficiency: diagnosis in patients with prolonged bleeding times and normal platelet aggregation","volume":"75","author":"Israels","year":"1990","journal-title":"Br J Haematol"},{"key":"10.1111\/jth.14363_bb0375","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1046\/j.1538-7836.2003.00266.x","article-title":"Inherited platelet\u2010based bleeding disorders","volume":"1","author":"Cattaneo","year":"2003","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0380","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1111\/jth.12334","article-title":"An adenine insertion in exon\u00a06 of human GP6 generates a truncated protein associated with a bleeding disorder in 4 Chilean families","volume":"11","author":"Matus","year":"2013","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0385","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/318470a0","article-title":"Human blood platelets showing no response to collagen fail to express surface glycoprotein\u00a0Ia","volume":"318","author":"Nieuwenhuis","year":"1985","journal-title":"Nature"},{"issue":"Suppl. 1","key":"10.1111\/jth.14363_bb0390","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1111\/jth.12952","article-title":"P2Y12 receptors: structure and function","volume":"13","author":"Cattaneo","year":"2015","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0395","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/jth.12117","article-title":"Platelet dysfunction associated with the novel Trp29Cys thromboxane\u00a0A(2) receptor variant","volume":"11","author":"Mumford","year":"2013","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0400","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1055\/s-0031-1291382","article-title":"Quebec platelet disorder: update on pathogenesis, diagnosis, and treatment","volume":"37","author":"Blavignac","year":"2011","journal-title":"Semin Thromb Hemost"},{"key":"10.1111\/jth.14363_bb0405","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1600-0609.1969.tb01955.x","article-title":"The blood platelet release reaction","volume":"8","author":"Holmsen","year":"1969","journal-title":"Scand J Haematol Suppl"},{"key":"10.1111\/jth.14363_bb0410","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1309\/AJCP9IPR1TFLUAGM","article-title":"Diagnostic usefulness of a lumi\u2010aggregometer adenosine triphosphate release assay for the assessment of platelet function disorders","volume":"136","author":"Pai","year":"2011","journal-title":"Am J Clin Pathol"},{"key":"10.1111\/jth.14363_bb0415","doi-asserted-by":"crossref","first-page":"e60396","DOI":"10.1371\/journal.pone.0060396","article-title":"Prevalence of disease and relationships between laboratory phenotype and bleeding severity in platelet primary secretion defects","volume":"8","author":"Lotta","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1111\/jth.14363_bb0420","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/ijlh.12553","article-title":"Variability in platelet dense granule adenosine triphosphate release findings amongst patients tested multiple times as part of an assessment for a bleeding disorder","volume":"38","author":"Badin","year":"2016","journal-title":"Int J Lab Hematol"},{"key":"10.1111\/jth.14363_bb0425","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1160\/TH14-11-0999","article-title":"A review of platelet secretion assays for the diagnosis of inherited platelet secretion disorders","volume":"114","author":"Mumford","year":"2015","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0430","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1373\/clinchem.2011.163824","article-title":"The measurement of platelet\u2010poor plasma serotonin: a systematic review of prior reports and recommendations for improved analysis","volume":"57","author":"Brand","year":"2011","journal-title":"Clin Chem"},{"key":"10.1111\/jth.14363_bb0435","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1111\/jth.13784","article-title":"Comparison of multiple electrode aggregometry with lumi\u2010aggregometry for the diagnosis of patients with mild bleeding disorders","volume":"15","author":"Al Ghaithi","year":"2017","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0440","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1182\/blood-2016-03-378588","article-title":"Inherited platelet disorders: toward DNA\u2010based diagnosis","volume":"127","author":"Lentaigne","year":"2016","journal-title":"Blood"},{"key":"10.1111\/jth.14363_bb0445","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.3324\/haematol.2011.042077","article-title":"Novel loci involved in platelet function and platelet count identified by a genome\u2010wide study performed in children","volume":"96","author":"Guerrero","year":"2011","journal-title":"Haematologica"},{"key":"10.1111\/jth.14363_bb0450","first-page":"161","article-title":"A whole genome approach to platelet and bleeding disorders","volume":"36","author":"Laffan","year":"2016","journal-title":"Hamostaseologie"},{"key":"10.1111\/jth.14363_bb0455","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1046\/j.1365-2516.1998.440683.x","article-title":"The management of factor\u00a0XI deficiency","volume":"4","author":"Bolton\u2010Maggs","year":"1998","journal-title":"Haemophilia"},{"key":"10.1111\/jth.14363_bb0460","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1538-7836.2005.01709.x","article-title":"Evaluation of low PAI\u20101 activity as a risk factor for hemorrhagic diathesis","volume":"4","author":"Agren","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0465","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00277-016-2893-6","article-title":"Fibrinolysis in patients with a mild\u2010to\u2010moderate bleeding tendency of unknown cause","volume":"96","author":"Gebhart","year":"2017","journal-title":"Ann Hematol"},{"key":"10.1111\/jth.14363_bb0470","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3109\/09537104.2011.596957","article-title":"Clot lysis time in platelet\u2010rich plasma: method assessment, comparison with assays in platelet\u2010free and platelet\u2010poor plasmas, and response to tranexamic acid","volume":"23","author":"Panes","year":"2012","journal-title":"Platelets"},{"key":"10.1111\/jth.14363_bb0475","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1111\/j.1538-7836.2008.03168.x","article-title":"Some hemostasis variables at the end of the population distributions are risk factors for severe postpartum hemorrhages","volume":"6","author":"Chauleur","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14363_bb0480","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1542\/peds.90.1.33","article-title":"A role for prostacyclin in bruising symptomatology","volume":"90","author":"Gerrard","year":"1992","journal-title":"Pediatrics"},{"key":"10.1111\/jth.14363_bb0485","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/00005344-199508000-00022","article-title":"Effect of nitric oxide synthase inhibition on bleeding time in humans","volume":"26","author":"Simon","year":"1995","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1111\/jth.14363_bb0490","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.bcp.2013.07.009","article-title":"Antiplatelet effect of AMP\u2010activated protein kinase activator and its potentiation by the phosphodiesterase inhibitor dipyridamole","volume":"86","author":"Liu","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"10.1111\/jth.14363_bb0495","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1161\/01.ATV.0000116219.09040.8c","article-title":"Membrane\u2010potential\u2010dependent inhibition of platelet adhesion to endothelial cells by epoxyeicosatrienoic acids","volume":"24","author":"Krotz","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/jth.14363_bb0500","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3233\/CH-2012-1614","article-title":"Effect of cytochrome\u00a0P450\u2010dependent epoxyeicosanoids on ristocetin\u2010induced thrombocyte aggregation","volume":"52","author":"Jung","year":"2012","journal-title":"Clin Hemorheol Microcirc"},{"key":"10.1111\/jth.14363_bb0505","doi-asserted-by":"crossref","first-page":"e2016049","DOI":"10.4084\/mjhid.2016.049","article-title":"Mild bleeders: diagnosis is elusive in large number of patients","volume":"8","author":"Kotru","year":"2016","journal-title":"Mediterr J Hematol Infect Dis"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.14363","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.14363","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jth.14363","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622024667?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622024667?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.14363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:23:22Z","timestamp":1761535402000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622024667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":100,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S1538783622024667"],"URL":"https:\/\/doi.org\/10.1111\/jth.14363","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnostic challenges of inherited mild bleeding disorders: a bait for poorly explored clinical and basic research","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/jth.14363","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2018 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}