{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:21:55Z","timestamp":1777562515379,"version":"3.51.4"},"reference-count":115,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":943,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1111\/jth.14549","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T16:24:18Z","timestamp":1561047858000},"page":"1417-1429","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Sex matters: Practice 5P's when treating young women with venous thromboembolism"],"prefix":"10.1016","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1155-4143","authenticated-orcid":false,"given":"Ingrid M.","family":"Bistervels","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5282-5520","authenticated-orcid":false,"given":"Luuk J.J.","family":"Scheres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9340-8771","authenticated-orcid":false,"given":"Eva N.","family":"Hamuly\u00e1k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1006-6420","authenticated-orcid":false,"given":"Saskia","family":"Middeldorp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1111\/jth.14549_bb0010","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1161\/ATVBAHA.114.304488","article-title":"Thrombosis: a major contributor to global disease burden","volume":"34","author":"Raskob","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"7","key":"10.1111\/jth.14549_bb0015","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1111\/jth.13712","article-title":"Sex\u2010specific differences in the presenting location of a first venous thromboembolism","volume":"15","author":"Scheres","year":"2017","journal-title":"J Thromb Haemost"},{"issue":"3","key":"10.1111\/jth.14549_bb0020","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.blre.2014.03.005","article-title":"Sex, thrombosis and inherited thrombophilia","volume":"28","author":"Bleker","year":"2014","journal-title":"Blood Rev"},{"issue":"4","key":"10.1111\/jth.14549_bb0025","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1056\/NEJM199107253250408","article-title":"The Yentl syndrome","volume":"325","author":"Healy","year":"1991","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1111\/jth.14549_bb0030","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1538-7836.2007.02450.x","article-title":"Incidence and mortality of venous thrombosis: a population\u2010based study","volume":"5","author":"Naess","year":"2007","journal-title":"J Thromb Haemost"},{"issue":"5","key":"10.1111\/jth.14549_bb0035","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1160\/TH16-03-0205","article-title":"Current incidence of venous thromboembolism and comparison with 1998: a community\u2010based study in Western France","volume":"116","author":"Delluc","year":"2016","journal-title":"Thromb Haemost"},{"issue":"12","key":"10.1111\/jth.14549_bb0040","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1111\/jth.13868","article-title":"Relationship between neighborhood socioeconomic status and venous thromboembolism: results from a population\u2010based study","volume":"15","author":"Kort","year":"2017","journal-title":"J Thromb Haemost"},{"issue":"2","key":"10.1111\/jth.14549_bb0045","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1160\/TH16-07-0509","article-title":"Reasons for the persistent incidence of venous thromboembolism","volume":"117","author":"Heit","year":"2017","journal-title":"Thromb Haemost"},{"issue":"1","key":"10.1111\/jth.14549_bb0050","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1161\/CIRCULATIONAHA.113.004768","article-title":"Sex difference in risk of second but not of first venous thrombosis: paradox explained","volume":"129","author":"Roach","year":"2014","journal-title":"Circulation"},{"issue":"10","key":"10.1111\/jth.14549_bb0055","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1111\/jth.13116","article-title":"Sex difference in the risk of recurrent venous thrombosis: a detailed analysis in four European cohorts","volume":"13","author":"Roach","year":"2015","journal-title":"J Thromb Haemost"},{"issue":"1","key":"10.1111\/jth.14549_bb0060","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ijgo.2010.11.011","article-title":"Disorders FWGoM. FIGO classification system (PALM\u2010COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age","volume":"113","author":"Munro","year":"2011","journal-title":"Int J Gynaecol Obstet"},{"issue":"12","key":"10.1111\/jth.14549_bb0065","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1111\/j.1440-1754.2011.02101.x","article-title":"Effect of warfarin on menstruation and menstrual management of the adolescent on warfarin","volume":"47","author":"Peake","year":"2011","journal-title":"J Paediatr Child Health"},{"issue":"4","key":"10.1111\/jth.14549_bb0070","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.thromres.2015.07.030","article-title":"Abnormal uterine bleeding in VTE patients treated with rivaroxaban compared to vitamin K antagonists","volume":"136","author":"De Crem","year":"2015","journal-title":"Thromb Res"},{"issue":"1","key":"10.1111\/jth.14549_bb0075","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11239-006-0003-7","article-title":"Menorrhagia and minor bleeding symptoms in women on oral anticoagulation","volume":"24","author":"Sjalander","year":"2007","journal-title":"J Thromb Thrombolysis"},{"issue":"2","key":"10.1111\/jth.14549_bb0080","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.chest.2015.11.026","article-title":"Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report","volume":"149","author":"Kearon","year":"2016","journal-title":"Chest"},{"issue":"11","key":"10.1111\/jth.14549_bb0085","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1182\/blood-2015-08-665927","article-title":"Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use","volume":"127","author":"Martinelli","year":"2016","journal-title":"Blood"},{"issue":"4","key":"10.1111\/jth.14549_bb0090","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1160\/TH16-11-0874","article-title":"Abnormal vaginal bleeding in women with venous thromboembolism treated with apixaban or warfarin","volume":"117","author":"Brekelmans","year":"2017","journal-title":"Thromb Haemost"},{"issue":"12","key":"10.1111\/jth.14549_bb0095","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1111\/1471-0528.15388","article-title":"Abnormal vaginal bleeding in women of reproductive age treated with edoxaban or warfarin for venous thromboembolism: a post hoc analysis of the Hokusai\u2010VTE study","volume":"125","author":"Scheres","year":"2018","journal-title":"BJOG"},{"issue":"10","key":"10.1111\/jth.14549_bb0100","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1160\/TH16-12-0946","article-title":"Clinical impact of major bleeding in patients with venous thromboembolism treated with factor Xa inhibitors or vitamin K antagonists","volume":"117","author":"Bleker","year":"2017","journal-title":"Thromb Haemost"},{"issue":"9","key":"10.1111\/jth.14549_bb0105","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1111\/jth.14226","article-title":"Less abnormal uterine bleeding with dabigatran than warfarin in women treated for acute venous thromboembolism","volume":"169","author":"Huisman","year":"2018","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14549_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2017.05.001","article-title":"Abnormal uterine bleeding in women receiving direct oral anticoagulants for the treatment of venous thromboembolism","volume":"93\u201395","author":"Godin","year":"2017","journal-title":"Vascul Pharmacol"},{"issue":"24","key":"10.1111\/jth.14549_bb0115","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1182\/blood-2017-07-797423","article-title":"How I treat heavy menstrual bleeding associated with anticoagulants","volume":"130","author":"Boonyawat","year":"2017","journal-title":"Blood"},{"key":"10.1111\/jth.14549_bb0120","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.thromres.2017.03.013","article-title":"Oral contraception and menstrual bleeding during treatment of venous thromboembolism: expert opinion versus current practice: combined results of a systematic review, expert panel opinion and an international survey","volume":"153","author":"Klok","year":"2017","journal-title":"Thromb Res"},{"issue":"10","key":"10.1111\/jth.14549_bb0125","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1093\/humrep\/der224","article-title":"Effective treatment of heavy and\/or prolonged menstrual bleeding with an oral contraceptive containing estradiol valerate and dienogest: a randomized, double\u2010blind Phase III trial","volume":"26","author":"Fraser","year":"2011","journal-title":"Hum Reprod"},{"key":"10.1111\/jth.14549_bb0130","first-page":"CD002126","article-title":"Progesterone or progestogen\u2010releasing intrauterine systems for heavy menstrual bleeding","volume":"4","author":"Lethaby","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"issue":"11","key":"10.1111\/jth.14549_bb0135","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1161\/ATVBAHA.110.211482","article-title":"The risk of deep venous thrombosis associated with injectable depot\u2010medroxyprogesterone acetate contraceptives or a levonorgestrel intrauterine device","volume":"30","author":"van Hylckama","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/jth.14549_bb0140","doi-asserted-by":"crossref","first-page":"e2990","DOI":"10.1136\/bmj.e2990","article-title":"Venous thrombosis in users of non\u2010oral hormonal contraception: follow\u2010up study, Denmark 2001\u201010","volume":"344","author":"Lidegaard","year":"2012","journal-title":"BMJ"},{"issue":"3","key":"10.1111\/jth.14549_bb0145","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1097\/AOG.0000000000000411","article-title":"Association of venous thromboembolism with hormonal contraception and thrombophilic genotypes","volume":"124","author":"Bergendal","year":"2014","journal-title":"Obstet Gynecol"},{"issue":"2","key":"10.1111\/jth.14549_bb0150","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.contraception.2009.02.007","article-title":"The effect of levonorgestrel\u2010releasing intrauterine device on menorrhagia in women taking anticoagulant medication after cardiac valve replacement","volume":"80","author":"Kilic","year":"2009","journal-title":"Contraception"},{"key":"10.1111\/jth.14549_bb0155","first-page":"CD000249","article-title":"Antifibrinolytics for heavy menstrual bleeding","volume":"4","author":"Bryant\u2010Smith","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1111\/jth.14549_bb0160","series-title":"Heavy menstrual bleeding","year":"2018"},{"key":"10.1111\/jth.14549_bb0165","unstructured":"European Medicines Agency. Antifibrinolytics containing aprotinin, aminocoproic acid and tranexamic acid. Assessment report. https:\/\/www.ema.europa.eu\/documents\/referral\/assessment-report-antifibrinolytic-medicines-tranexamic-acid_en.pdf2012"},{"issue":"10084","key":"10.1111\/jth.14549_bb0170","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/S0140-6736(17)30638-4","article-title":"Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post\u2010partum haemorrhage (WOMAN): an international, randomised, double\u2010blind, placebo\u2010controlled trial","volume":"389","author":"Shakur","year":"2017","journal-title":"Lancet"},{"issue":"9734","key":"10.1111\/jth.14549_bb0175","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0140-6736(10)60835-5","article-title":"Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH\u20102): a randomised, placebo\u2010controlled trial","volume":"376","author":"Shakur","year":"2010","journal-title":"Lancet"},{"key":"10.1111\/jth.14549_bb0180","unstructured":"Boonyawat KL A., Prins M., Prandoni P., Weitz J.I., Crowther M. Menstrual bleeding patterns in women treated with rivaroxaban: Data from the EINSTEIN CHOICE trial. Paper presented at the XXVI Congress of the International Society on Thrombosis and Haemostasis. 8\u201013 July 2017. Berlin, Germany 2017."},{"key":"10.1111\/jth.14549_bb0185","unstructured":"United Nations. World Contraceptive Use 2018. Department of Economic and Social Affairs, Population Division. 2018."},{"issue":"2","key":"10.1111\/jth.14549_bb0190","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/rth2.12101","article-title":"Current and future burden of venous thrombosis: not simply predictable","volume":"2","author":"Scheres","year":"2018","journal-title":"Res Pract Thromb Haemost"},{"issue":"1","key":"10.1111\/jth.14549_bb0195","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.beem.2012.11.004","article-title":"History of oral contraceptive drugs and their use worldwide","volume":"27","author":"Christin\u2010Maitre","year":"2013","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"3","key":"10.1111\/jth.14549_bb0200","first-page":"CD010813","article-title":"Combined oral contraceptives: venous thrombosis","author":"de Bastos","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1111\/jth.14549_bb0205","doi-asserted-by":"crossref","first-page":"f5298","DOI":"10.1136\/bmj.f5298","article-title":"Different combined oral contraceptives and the risk of venous thrombosis: systematic review and network meta\u2010analysis","volume":"347","author":"Stegeman","year":"2013","journal-title":"BMJ"},{"key":"10.1111\/jth.14549_bb0210","doi-asserted-by":"crossref","first-page":"d2758","DOI":"10.1136\/bmj.d2758","article-title":"Duration of anticoagulation for venous thromboembolism","volume":"342","author":"Middeldorp","year":"2011","journal-title":"BMJ"},{"issue":"9383","key":"10.1111\/jth.14549_bb0215","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0140-6736(03)14111-6","article-title":"Incidence of recurrent venous thromboembolism in relation to clinical and thrombophilic risk factors: prospective cohort study","volume":"362","author":"Baglin","year":"2003","journal-title":"Lancet"},{"issue":"7","key":"10.1111\/jth.14549_bb0220","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1182\/bloodadvances.2018017160","article-title":"Risk of recurrent venous thromboembolism according to baseline risk factor profiles","volume":"2","author":"Prins","year":"2018","journal-title":"Blood Adv"},{"key":"10.1111\/jth.14549_bb0225","doi-asserted-by":"crossref","first-page":"d813","DOI":"10.1136\/bmj.d813","article-title":"Risk of recurrence after venous thromboembolism in men and women: patient level meta\u2010analysis","volume":"342","author":"Douketis","year":"2011","journal-title":"BMJ"},{"issue":"12","key":"10.1111\/jth.14549_bb0230","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1111\/jth.13524","article-title":"The long\u2010term recurrence risk of patients with unprovoked venous thromboembolism: an observational cohort study","volume":"14","author":"Kyrle","year":"2016","journal-title":"J Thromb Haemost"},{"issue":"11","key":"10.1111\/jth.14549_bb0235","doi-asserted-by":"crossref","first-page":"893","DOI":"10.7326\/0003-4819-139-11-200312020-00007","article-title":"Clinical impact of bleeding in patients taking oral anticoagulant therapy for venous thromboembolism: a meta\u2010analysis","volume":"139","author":"Linkins","year":"2003","journal-title":"Ann Intern Med"},{"issue":"12","key":"10.1111\/jth.14549_bb0240","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1182\/blood-2014-04-571232","article-title":"Direct oral anticoagulants compared with vitamin K antagonists for acute venous thromboembolism: evidence from phase 3 trials","volume":"124","author":"van Es","year":"2014","journal-title":"Blood"},{"issue":"5","key":"10.1111\/jth.14549_bb0245","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1001\/archinte.159.5.457","article-title":"Prediction of the risk of bleeding during anticoagulant treatment for venous thromboembolism","volume":"159","author":"Kuijer","year":"1999","journal-title":"Arch Intern Med"},{"issue":"26","key":"10.1111\/jth.14549_bb0250","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1056\/NEJMoa1007903","article-title":"Oral rivaroxaban for symptomatic venous thromboembolism","volume":"363","author":"Investigators","year":"2010","journal-title":"N Engl J Med"},{"issue":"14","key":"10.1111\/jth.14549_bb0255","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1056\/NEJMoa1113572","article-title":"Oral rivaroxaban for the treatment of symptomatic pulmonary embolism","volume":"366","author":"Investigators","year":"2012","journal-title":"N Engl J Med"},{"issue":"15","key":"10.1111\/jth.14549_bb0260","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1056\/NEJMoa1306638","article-title":"Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism","volume":"369","author":"Hokusai","year":"2013","journal-title":"N Engl J Med"},{"issue":"8","key":"10.1111\/jth.14549_bb0265","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJMoa1113697","article-title":"Extended use of dabigatran, warfarin, or placebo in venous thromboembolism","volume":"368","author":"Schulman","year":"2013","journal-title":"N Engl J Med"},{"issue":"8","key":"10.1111\/jth.14549_bb0270","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJMoa1207541","article-title":"Apixaban for extended treatment of venous thromboembolism","volume":"368","author":"Agnelli","year":"2013","journal-title":"N Engl J Med"},{"issue":"13","key":"10.1111\/jth.14549_bb0275","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1056\/NEJMoa1700518","article-title":"Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism","volume":"376","author":"Weitz","year":"2017","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1111\/jth.14549_bb0280","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1503\/cmaj.080493","article-title":"Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy","volume":"179","author":"Rodger","year":"2008","journal-title":"CMAJ"},{"key":"10.1111\/jth.14549_bb0285","doi-asserted-by":"crossref","first-page":"j2073","DOI":"10.1136\/bmj.j2073","article-title":"Oral contraceptive use is a provoking factor for venous thromboembolism","volume":"357","author":"Middeldorp","year":"2017","journal-title":"BMJ"},{"key":"10.1111\/jth.14549_bb0290","doi-asserted-by":"crossref","first-page":"j1065","DOI":"10.1136\/bmj.j1065","article-title":"Validating the HERDOO2 rule to guide treatment duration for women with unprovoked venous thrombosis: multinational prospective cohort management study","volume":"356","author":"Rodger","year":"2017","journal-title":"BMJ"},{"key":"10.1111\/jth.14549_bb0295","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.thromres.2018.07.020","article-title":"\u201cHERDOO2\u201d clinical decision rule to guide duration of anticoagulation in women with unprovoked venous thromboembolism. Can I use any d\u2010Dimer?","volume":"169","author":"Rodger","year":"2018","journal-title":"Thromb Res"},{"issue":"5","key":"10.1111\/jth.14549_bb0300","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.ajog.2005.11.008","article-title":"Venous thromboembolism during pregnancy and the postpartum period: incidence, risk factors, and mortality","volume":"194","author":"James","year":"2006","journal-title":"Am J Obstet Gynecol"},{"issue":"5\u20136","key":"10.1111\/jth.14549_bb0305","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.thromres.2004.08.004","article-title":"Haemostatic changes in pregnancy","volume":"114","author":"Brenner","year":"2004","journal-title":"Thromb Res"},{"issue":"6","key":"10.1111\/jth.14549_bb0310","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1055\/s-0037-1615035","article-title":"Activated protein C sensitivity, protein C, protein S and coagulation in normal pregnancy","volume":"79","author":"Clark","year":"1998","journal-title":"Thromb Haemost"},{"issue":"3","key":"10.1111\/jth.14549_bb0315","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1160\/TH05-11-0753","article-title":"Haemostasis and pregnancy","volume":"95","author":"Franchini","year":"2006","journal-title":"Thromb Haemost"},{"issue":"2","key":"10.1111\/jth.14549_bb0320","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jvsv.2017.08.001","article-title":"The hemodynamic effects of pregnancy on the lower extremity venous system","volume":"6","author":"Taylor","year":"2018","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"issue":"1","key":"10.1111\/jth.14549_bb0325","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ijgo.2015.06.054","article-title":"A systematic review and meta\u2010analysis of the epidemiology and burden of venous thromboembolism among pregnant women","volume":"132","author":"Kourlaba","year":"2016","journal-title":"Int J Gynaecol Obstet"},{"issue":"10","key":"10.1111\/jth.14549_bb0330","doi-asserted-by":"crossref","first-page":"697","DOI":"10.7326\/0003-4819-143-10-200511150-00006","article-title":"Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30\u2010year population\u2010based study","volume":"143","author":"Heit","year":"2005","journal-title":"Ann Intern Med"},{"issue":"2","key":"10.1111\/jth.14549_bb0335","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00404-013-2923-8","article-title":"Trends, risk factors and mortality among women with venous thromboembolism during labour and delivery: a population\u2010based study of 8 million births","volume":"289","author":"Abbasi","year":"2014","journal-title":"Arch Gynecol Obstet"},{"issue":"6","key":"10.1111\/jth.14549_bb0340","doi-asserted-by":"crossref","first-page":"e323","DOI":"10.1016\/S2214-109X(14)70227-X","article-title":"Global causes of maternal death: a WHO systematic analysis","volume":"2","author":"Say","year":"2014","journal-title":"Lancet Glob Health"},{"issue":"3","key":"10.1111\/jth.14549_bb0345","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1365-2141.2006.06317.x","article-title":"The risk of recurrent venous thromboembolism in pregnancy and puerperium without antithrombotic prophylaxis","volume":"135","author":"De Stefano","year":"2006","journal-title":"Br J Haematol"},{"issue":"5","key":"10.1111\/jth.14549_bb0350","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1111\/j.1538-7836.2005.01307.x","article-title":"Risk of pregnancy\u2010associated recurrent venous thromboembolism in women with a history of venous thrombosis","volume":"3","author":"Pabinger","year":"2005","journal-title":"J Thromb Haemost"},{"issue":"20","key":"10.1111\/jth.14549_bb0355","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1056\/NEJM200011163432002","article-title":"Safety of withholding heparin in pregnant women with a history of venous thromboembolism: recurrence of clot in this pregnancy study group","volume":"343","author":"Brill\u2010Edwards","year":"2000","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1111\/jth.14549_bb0360","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1160\/TH08-04-0238","article-title":"Recurrent venous thromboembolism after pregnancy\u2010associated versus unprovoked thromboembolism","volume":"100","author":"White","year":"2008","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.14549_bb0365","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.thromres.2018.05.005","article-title":"Prevention of venous thromboembolism in pregnant patients with a history of venous thromboembolic disease: a retrospective cohort study","volume":"167","author":"Lazo\u2010Langner","year":"2018","journal-title":"Thromb Res"},{"issue":"2 Suppl","key":"10.1111\/jth.14549_bb0370","doi-asserted-by":"crossref","first-page":"e691S","DOI":"10.1378\/chest.11-2300","article-title":"VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence\u2010Based Clinical Practice Guidelines","volume":"141","author":"Bates","year":"2012","journal-title":"Chest"},{"issue":"22","key":"10.1111\/jth.14549_bb0375","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1182\/bloodadvances.2018024802","article-title":"American Society of Hematology 2018 guidelines for management of venous thromboembolism: venous thromboembolism in the context of pregnancy","volume":"2","author":"Bates","year":"2018","journal-title":"Blood Adv"},{"issue":"6","key":"10.1111\/jth.14549_bb0380","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1046\/j.0306-5251.2001.01517.x","article-title":"Excretion of low molecular weight heparin in human milk","volume":"52","author":"Richter","year":"2001","journal-title":"Br J Clin Pharmacol"},{"key":"10.1111\/jth.14549_bb0385","unstructured":"Gynaecologists RCOG. Thrombosis and Embolism during Pregnancy and the Puerperium, the Acute Management of (Green\u2010top Guideline No. 37b). 2015."},{"issue":"1","key":"10.1111\/jth.14549_bb0390","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0031-6997(25)06718-3","article-title":"Low molecular weight heparin: a critical analysis of clinical trials","volume":"46","author":"Green","year":"1994","journal-title":"Pharmacol Rev"},{"issue":"8812","key":"10.1111\/jth.14549_bb0395","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/0140-6736(92)93223-A","article-title":"Low\u2010molecular\u2010weight heparin versus standard heparin in general and orthopaedic surgery: a meta\u2010analysis","volume":"340","author":"Nurmohamed","year":"1992","journal-title":"Lancet"},{"issue":"2","key":"10.1111\/jth.14549_bb0400","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1182\/blood-2005-02-0626","article-title":"Low\u2010molecular\u2010weight heparins for thromboprophylaxis and treatment of venous thromboembolism in pregnancy: a systematic review of safety and efficacy","volume":"106","author":"Greer","year":"2005","journal-title":"Blood"},{"issue":"2","key":"10.1111\/jth.14549_bb0405","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ejogrb.2011.08.005","article-title":"Tinzaparin use in pregnancy: an international, retrospective study of the safety and efficacy profile","volume":"159","author":"Nelson\u2010Piercy","year":"2011","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"2","key":"10.1111\/jth.14549_bb0410","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ejogrb.2012.05.010","article-title":"Safety of low\u2010molecular\u2010weight heparin during pregnancy: a retrospective controlled cohort study","volume":"163","author":"Galambosi","year":"2012","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"Suppl 1","key":"10.1111\/jth.14549_bb0415","doi-asserted-by":"crossref","first-page":"18","DOI":"10.2298\/SARH10S1018M","article-title":"Efficacy and safety of nadroparin and unfractionated heparin for the treatment of venous thromboembolism during pregnancy and puerperium","volume":"138","author":"Mitic","year":"2010","journal-title":"Srp Arh Celok Lek"},{"issue":"3","key":"10.1111\/jth.14549_bb0420","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1538-7836.2011.04186.x","article-title":"Prophylaxis with low\u2010dose low\u2010molecular\u2010weight heparin during pregnancy and postpartum: is it effective?","volume":"9","author":"Roeters van Lennep","year":"2011","journal-title":"J Thromb Haemost"},{"issue":"9955","key":"10.1111\/jth.14549_bb0425","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/S0140-6736(14)60793-5","article-title":"Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia (TIPPS): a multinational open\u2010label randomised trial","volume":"384","author":"Rodger","year":"2014","journal-title":"Lancet"},{"issue":"1","key":"10.1111\/jth.14549_bb0430","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/0002-9378(89)90095-1","article-title":"Matzsch T, Bergqvist A, Hedner U. Recurrent thromboembolism in pregnancy and puerperium. Is there a need for thromboprophylaxis?","volume":"160","author":"Tengborn","year":"1989","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"10.1111\/jth.14549_bb0435","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.ajog.2004.03.039","article-title":"Bowler U, Thromboprophylaxis in Pregnancy Advisory G. Thromboprophylaxis and pregnancy: two randomized controlled pilot trials that used low\u2010molecular\u2010weight heparin","volume":"191","author":"Gates","year":"2004","journal-title":"Am J Obstet Gynecol"},{"issue":"12","key":"10.1111\/jth.14549_bb0440","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1111\/j.1471-0528.1983.tb06458.x","article-title":"The risks of antenatal subcutaneous heparin prophylaxis: a controlled trial","volume":"90","author":"Howell","year":"1983","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1111\/jth.14549_bb0445","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.thromres.2016.06.001","article-title":"Low\u2010molecular\u2010weight heparin to prevent recurrent venous thromboembolism in pregnancy: rationale and design of the Highlow study, a randomised trial of two doses","volume":"144","author":"Bleker","year":"2016","journal-title":"Thromb Res"},{"key":"10.1111\/jth.14549_bb0450","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.blre.2018.08.001","article-title":"Everything the clinician needs to know about evidence\u2010based anticoagulation in pregnancy","volume":"33","author":"Scheres","year":"2019","journal-title":"Blood Rev"},{"issue":"8","key":"10.1111\/jth.14549_bb0455","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1111\/jth.13366","article-title":"Management of direct oral anticoagulants in women of childbearing potential: guidance from the SSC of the ISTH","volume":"14","author":"Cohen","year":"2016","journal-title":"J Thromb Haemost"},{"issue":"1","key":"10.1111\/jth.14549_bb0460","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1160\/TH07-04-0266","article-title":"Vitamin K: the coagulation vitamin that became omnipotent","volume":"98","author":"Cranenburg","year":"2007","journal-title":"Thromb Haemost"},{"issue":"1","key":"10.1111\/jth.14549_bb0465","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/jth.13484","article-title":"Management of direct oral anticoagulants in women of childbearing potential: guidance from the SSC of the ISTH: comment","volume":"15","author":"Desborough","year":"2017","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14549_bb0470","unstructured":"Haemostatsis WsHSaSCotISoTa. DOAC in pregnancy registry. https:\/\/cdn.ymaws.com\/www.isth.org\/resource\/group\/a9f3a2ba-d3e5-4bb6-8b82-508d3c002a06\/projects\/2015-10-27_SSC_Subcommittee_pdf."},{"issue":"20","key":"10.1111\/jth.14549_bb0475","doi-asserted-by":"crossref","first-page":"5394","DOI":"10.1182\/blood-2011-04-306589","article-title":"How I treat pregnancy\u2010related venous thromboembolism","volume":"118","author":"Middeldorp","year":"2011","journal-title":"Blood"},{"issue":"3","key":"10.1111\/jth.14549_bb0480","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1177\/096721090100900302","article-title":"Development of oral heparin therapy for prophylaxis and treatment of deep venous thrombosis","volume":"9","author":"Money","year":"2001","journal-title":"Cardiovasc Surg"},{"issue":"18","key":"10.1111\/jth.14549_bb0485","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1161\/CIR.0000000000000130","article-title":"The postthrombotic syndrome: evidence\u2010based prevention, diagnosis, and treatment strategies: a scientific statement from the American Heart Association","volume":"130","author":"Kahn","year":"2014","journal-title":"Circulation"},{"issue":"2","key":"10.1111\/jth.14549_bb0490","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.blre.2015.09.002","article-title":"The post thrombotic syndrome: ignore it and it will come back to bite you","volume":"30","author":"ten Cate\u2010Hoek","year":"2016","journal-title":"Blood Rev"},{"issue":"9054","key":"10.1111\/jth.14549_bb0495","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0140-6736(96)12215-7","article-title":"Randomised trial of effect of compression stockings in patients with symptomatic proximal\u2010vein thrombosis","volume":"349","author":"Brandjes","year":"1997","journal-title":"Lancet"},{"issue":"4","key":"10.1111\/jth.14549_bb0500","first-page":"423","article-title":"The clinical course of deep\u2010vein thrombosis. Prospective long\u2010term follow\u2010up of 528 symptomatic patients","volume":"82","author":"Prandoni","year":"1997","journal-title":"Haematologica"},{"issue":"3","key":"10.1111\/jth.14549_bb0505","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1365-2141.2009.07601.x","article-title":"Post\u2010thrombotic syndrome: prevalence, prognostication and need for progress","volume":"145","author":"Prandoni","year":"2009","journal-title":"Br J Haematol"},{"key":"10.1111\/jth.14549_bb0510","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1182\/asheducation.V2012.1.203.3798262","article-title":"Thrombosis in pregnancy: updates in diagnosis and management","volume":"2012","author":"Greer","year":"2012","journal-title":"Hematology Am Soc Hematol Educ Program"},{"issue":"10","key":"10.1111\/jth.14549_bb0515","doi-asserted-by":"crossref","first-page":"698","DOI":"10.7326\/0003-4819-149-10-200811180-00004","article-title":"Determinants and time course of the postthrombotic syndrome after acute deep venous thrombosis","volume":"149","author":"Kahn","year":"2008","journal-title":"Ann Intern Med"},{"issue":"5","key":"10.1111\/jth.14549_bb0520","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/j.1538-7836.2012.04690.x","article-title":"Prevalence and predictors for post\u2010thrombotic syndrome 3 to 16\u00a0years after pregnancy\u2010related venous thrombosis: a population\u2010based, cross\u2010sectional, case\u2010control study","volume":"10","author":"Wik","year":"2012","journal-title":"J Thromb Haemost"},{"issue":"1","key":"10.1111\/jth.14549_bb0525","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s11239-015-1312-5","article-title":"Guidance for the prevention and treatment of the post\u2010thrombotic syndrome","volume":"41","author":"Kahn","year":"2016","journal-title":"J Thromb Thrombolysis"},{"issue":"23","key":"10.1111\/jth.14549_bb0530","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1056\/NEJMoa1615066","article-title":"Pharmacomechanical Catheter\u2010Directed Thrombolysis for Deep\u2010Vein Thrombosis","volume":"377","author":"Vedantham","year":"2017","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1111\/jth.14549_bb0535","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1016\/S2352-3026(15)00248-3","article-title":"Post\u2010thrombotic syndrome after catheter\u2010directed thrombolysis for deep vein thrombosis (CaVenT): 5\u2010year follow\u2010up results of an open\u2010label, randomised controlled trial","volume":"3","author":"Haig","year":"2016","journal-title":"Lancet Haematol"},{"issue":"4","key":"10.1111\/jth.14549_bb0540","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1177\/0268355517698620","article-title":"Long\u2010term quality of life and postthrombotic syndrome in women after an episode of venous thromboembolism","volume":"33","author":"Ljungqvist","year":"2018","journal-title":"Phlebology"},{"issue":"6","key":"10.1111\/jth.14549_bb0545","doi-asserted-by":"crossref","first-page":"e002048","DOI":"10.1136\/bmjopen-2012-002048","article-title":"Long\u2010term impact of pregnancy\u2010related venous thrombosis on quality\u2010of\u2010life, general health and functioning: results of a cross\u2010sectional, case\u2010control study","volume":"2","author":"Wik","year":"2012","journal-title":"BMJ Open"},{"issue":"1","key":"10.1111\/jth.14549_bb0550","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/S2352-3026(17)30227-2","article-title":"Individualised versus standard duration of elastic compression therapy for prevention of post\u2010thrombotic syndrome (IDEAL DVT): a multicentre, randomised, single\u2010blind, allocation\u2010concealed, non\u2010inferiority trial","volume":"5","author":"Ten Cate\u2010Hoek","year":"2018","journal-title":"Lancet Haematol"},{"issue":"6","key":"10.1111\/jth.14549_bb0555","first-page":"612","article-title":"Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH\u20102) A randomised, placebo\u2010controlled trial","volume":"59","author":"Williams\u2010Johnson","year":"2010","journal-title":"West Indian Med J"},{"key":"10.1111\/jth.14549_bb0560","doi-asserted-by":"crossref","first-page":"e4944","DOI":"10.1136\/bmj.e4944","article-title":"Assessing the risk of venous thromboembolic events in women taking progestin\u2010only contraception: a meta\u2010analysis","volume":"345","author":"Mantha","year":"2012","journal-title":"BMJ"},{"key":"10.1111\/jth.14549_bb0565","doi-asserted-by":"crossref","first-page":"d6423","DOI":"10.1136\/bmj.d6423","article-title":"Risk of venous thromboembolism from use of oral contraceptives containing different progestogens and oestrogen doses: Danish cohort study, 2001\u20109","volume":"343","author":"Lidegaard","year":"2011","journal-title":"BMJ"},{"issue":"9190","key":"10.1111\/jth.14549_bb0570","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/S0140-6736(99)03132-3","article-title":"Risk of cardiovascular diseases associated with oral progestagen preparations with therapeutic indications","volume":"354","author":"Poulter","year":"1999","journal-title":"Lancet"},{"issue":"6","key":"10.1111\/jth.14549_bb0575","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1586\/17474086.2014.960385","article-title":"The real value of thrombophilia markers in identifying patients at high risk of venous thromboembolism","volume":"7","author":"Mannucci","year":"2014","journal-title":"Expert Rev Hematol"},{"issue":"3","key":"10.1111\/jth.14549_bb0580","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/nrcardio.2013.211","article-title":"Inherited risk factors for venous thromboembolism","volume":"11","author":"Martinelli","year":"2014","journal-title":"Nat Rev Cardiol"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.14549","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.14549","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jth.14549","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622141553?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622141553?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.14549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:14:22Z","timestamp":1761534862000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622141553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":115,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S1538783622141553"],"URL":"https:\/\/doi.org\/10.1111\/jth.14549","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex matters: Practice 5P's when treating young women with venous thromboembolism","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/jth.14549","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2019 The Authors. Journal of Thrombosis and Haemostasis. Published by ELSEVIER INC. on behalf of International Society on Thrombosis and Haemostasis","name":"copyright","label":"Copyright"}]}}