{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T22:58:27Z","timestamp":1778021907229,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":790,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1111\/jth.14652","type":"journal-article","created":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T22:11:29Z","timestamp":1569535889000},"page":"295-305","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["One piece of the puzzle: Population pharmacokinetics of FVIII during perioperative Haemate P\u00ae\/Humate P\u00ae treatment in von Willebrand disease patients"],"prefix":"10.1016","volume":"18","author":[{"given":"Nico C.B.","family":"de Jager","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7967-1023","authenticated-orcid":false,"given":"Laura H.","family":"Bukkems","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1069-8097","authenticated-orcid":false,"given":"Jessica M.","family":"Heijdra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolien H.C.A.M.","family":"Hazendonk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Fijnvandraat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina","family":"Meijer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3268-5759","authenticated-orcid":false,"given":"Jeroen","family":"Eikenboom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britta A.P.","family":"Laros - van Gorkom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank W.G.","family":"Leebeek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjon H.","family":"Cnossen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron A.A.","family":"Math\u00f4t","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.W.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.H.A.","family":"Kruip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Polinder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Lock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"van Moort","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.C.H.J.","family":"Goedhart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Coppens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Preijers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Brons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.J.M.","family":"van der Meer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.E.G.","family":"Schutgens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.H.E.","family":"Driessens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.M.","family":"Zwaan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"van Vliet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Liesner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Chowdary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Keeling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1111\/jth.14652_bb0010","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1055\/s-0037-1613992","article-title":"Impact, diagnosis and treatment of von Willebrand disease","volume":"84","author":"Sadler","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.14652_bb0015","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1182\/blood-2015-11-664680","article-title":"Rapid discrimination of the phenotypic variants of von Willebrand disease","volume":"127","author":"Roberts","year":"2016","journal-title":"Blood"},{"key":"10.1111\/jth.14652_bb0020","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1056\/NEJMra1601561","article-title":"Von Willebrand's disease","volume":"375","author":"Leebeek","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1111\/jth.14652_bb0025","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1111\/j.1538-7836.2006.02146.x","article-title":"Update on the pathophysiology and classification of von Willebrand disease: a report of the subcommittee on von Willebrand factor","volume":"4","author":"Sadler","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14652_bb0030","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/S0049-3848(09)70152-5","article-title":"Haemate P\/Humate\u2010P: a systematic review","volume":"124","author":"Berntorp","year":"2009","journal-title":"Thromb Res"},{"key":"10.1111\/jth.14652_bb0035","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/hae.13451","article-title":"Analysis of current perioperative management with Haemate\u00ae P\/Humate P\u00ae in von Willebrand disease: identifying the need for personalized treatment","volume":"24","author":"Hazendonk","year":"2018","journal-title":"Haemophilia"},{"key":"10.1111\/jth.14652_bb0040","first-page":"s33","article-title":"Surgical prophylaxis in von Willebrand's disease: a difficult balance to manage","volume":"6","author":"Franchini","year":"2008","journal-title":"Blood Transfus"},{"key":"10.1111\/jth.14652_bb0045","first-page":"9","article-title":"Treatment of von Willebrand disease with FVIII\/VWF concentrates","volume":"9","author":"Castaman","year":"2011","journal-title":"Blood Transfus"},{"key":"10.1111\/jth.14652_bb0050","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1600-0609.2008.01049.x","article-title":"A systematic overview of the first pasteurised VWF\/FVIII medicinal product, Haemate P\/ Humate \u2010P: history and clinical performance","volume":"70","author":"Berntorp","year":"2008","journal-title":"Eur J Haematol Suppl"},{"key":"10.1111\/jth.14652_bb0055","first-page":"193","article-title":"Replacement therapy with virus\u2010inactivated plasma concentrates in von Willebrand disease","volume":"62","author":"Rodeghiero","year":"1992","journal-title":"Vox Sang"},{"key":"10.1111\/jth.14652_bb0060","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/bjh.13064","article-title":"The diagnosis and management of von Willebrand disease: a United Kingdom haemophilia centre doctors organization guideline approved by the British committee for standards in haematology","volume":"167","author":"Laffan","year":"2014","journal-title":"Br J Haematol"},{"key":"10.1111\/jth.14652_bb0065","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1046\/j.1365-2516.2001.00096.x","article-title":"Use of ristocetin cofactor activity in the management of von Willebrand disease","volume":"7","author":"Ewenstein","year":"2001","journal-title":"Haemophilia"},{"key":"10.1111\/jth.14652_bb0070","unstructured":"Nederlandse Vereniging van Hemofiliebehandelaars (NVHB). Richtlijn: diagnostiek en behandeling van hemofilie en aanverwante hemostasestoornissen. Amsterdam, The Netherlands: Alphen aan den Rijn: Van Zuiden Communications B.V.; 2009."},{"key":"10.1111\/jth.14652_bb0075","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1111\/j.1538-7836.2007.02588.x","article-title":"von Willebrand factor\/factor VIII concentrate (Haemate\u00ae P) dosing based on pharmacokinetics: a prospective multicenter trial in elective surgery","volume":"5","author":"Lethagen","year":"2007","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14652_bb0080","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1182\/blood.V86.10.3676.bloodjournal86103676","article-title":"Surgery and anesthesia in sickle cell disease. Cooperative study of sickle cell diseases","volume":"86","author":"Koshy","year":"1995","journal-title":"Blood"},{"key":"10.1111\/jth.14652_bb0085","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1046\/j.1538-7836.2003.00190.x","article-title":"Cellular mechanisms of the hemostatic effects of desmopressin (DDAVP)","volume":"1","author":"Kaufmann","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14652_bb0090","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.cmpb.2010.04.018","article-title":"Pira\u00f1a and PCluster: a modeling environment and cluster infrastructure for NONMEM","volume":"101","author":"Keizer","year":"2011","journal-title":"Comput Methods Programs Biomed"},{"key":"10.1111\/jth.14652_bb0095","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.cmpb.2005.04.005","article-title":"PsN\u2010Toolkit \u2010 a collection of computer intensive statistical methods for non\u2010linear mixed effect modeling using NONMEM","volume":"79","author":"Lindbom","year":"2005","journal-title":"Comput Methods Programs Biomed"},{"key":"10.1111\/jth.14652_bb0100","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cmpb.2003.11.003","article-title":"Perl\u2010speaks\u2010NONMEM (PsN) \u2010 A perl module for NONMEM related programming","volume":"75","author":"Lindbom","year":"2004","journal-title":"Comput Methods Programs Biomed"},{"key":"10.1111\/jth.14652_bb0105","unstructured":"R Core Team. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing."},{"key":"10.1111\/jth.14652_bb0110","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1182\/blood.V118.21.2278.2278","article-title":"An increase in factor VIII levels with increasing age in a subgroup of individuals with mild hemophilia A","volume":"118","author":"Lee","year":"2011","journal-title":"Blood"},{"key":"10.1111\/jth.14652_bb0115","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/ajh.2830160304","article-title":"Changes in coagulation parameters with exercise in patients with classic hemophilia","volume":"16","author":"Koch","year":"1984","journal-title":"Am J Hematol"},{"key":"10.1111\/jth.14652_bb0120","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/bjh.15277","article-title":"Comorbidities associated with higher von Willebrand factor (VWF) levels may explain the age\u2010related increase of VWF in von Willebrand disease","volume":"182","author":"Atiq","year":"2018","journal-title":"Br J Haematol"},{"key":"10.1111\/jth.14652_bb0125","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev.pharmtox.48.113006.094708","article-title":"Mechanism\u2010based concepts of size and maturity in pharmacokinetics","volume":"48","author":"Anderson","year":"2008","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1111\/jth.14652_bb0130","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1023\/A:1011970125687","article-title":"Automated covariate model building within NONMEM","volume":"15","author":"Jonsson","year":"1998","journal-title":"Pharm Res"},{"key":"10.1111\/jth.14652_bb0135","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/j.1365-2516.2011.02583.x","article-title":"Presurgical pharmacokinetic analysis of a von Willebrand factor\/factor VIII (VWF\/FVIII) concentrate in patients with von Willebrand\u2019s disease (VWD) has limited value in dosing for surgery","volume":"17","author":"Di Paola","year":"2011","journal-title":"Haemophilia"},{"key":"10.1111\/jth.14652_bb0140","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1365-2516.2007.01643.x","article-title":"von Willebrand disease (VWD): evidence\u2010based diagnosis and management guidelines, the national heart, lung, and blood institute (NHLBI) expert panel report (USA)","volume":"14","author":"Nichols","year":"2008","journal-title":"Haemophilia"},{"key":"10.1111\/jth.14652_bb0145","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1213\/ANE.0000000000000740","article-title":"The effect of adding functional classification to ASA status for predicting 30\u2010day mortality","volume":"121","author":"Visnjevac","year":"2015","journal-title":"Anesth Analg"},{"key":"10.1111\/jth.14652_bb0150","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2516.2009.02005.x","article-title":"Factor VIII and von Willebrand factor interaction: biological, clinical and therapeutic importance","volume":"16","author":"Terraube","year":"2010","journal-title":"Haemophilia"},{"key":"10.1111\/jth.14652_bb0155","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/ejh.12514","article-title":"Interaction between VWF and FVIII in treating VWD","volume":"95","author":"Miesbach","year":"2015","journal-title":"Eur J Haematol"},{"key":"10.1111\/jth.14652_bb0160","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1042\/bj2570679","article-title":"The interaction between human blood\u2010coagulation factor VIII and von Willebrand factor: characterization of a high\u2010affinity binding site on factor VIII","volume":"257","author":"Leyte","year":"1989","journal-title":"Biochem J"},{"key":"10.1111\/jth.14652_bb0165","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1365-2516.1998.0040s3033.x","article-title":"Pharmacokinetics, efficacy and safety of Humate\u2010P\u00ae in von Willebrand disease","volume":"4","author":"Dobrkovska","year":"1998","journal-title":"Haemophilia"},{"key":"10.1111\/jth.14652_bb0170","first-page":"494","article-title":"Factor VIII half life and clinical phenotype of severe hemophilia A","volume":"90","author":"Van Dijk","year":"2005","journal-title":"Haematologica"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.14652","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.14652","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jth.14652","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622014933?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622014933?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.14652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:27:10Z","timestamp":1761535630000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622014933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S1538783622014933"],"URL":"https:\/\/doi.org\/10.1111\/jth.14652","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"One piece of the puzzle: Population pharmacokinetics of FVIII during perioperative Haemate P\u00ae\/Humate P\u00ae treatment in von Willebrand disease patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/jth.14652","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2019 The Authors. Journal of Thrombosis and Haemostasis. Published by ELSEVIER INC. on behalf of International Society on Thrombosis and Haemostasis","name":"copyright","label":"Copyright"}]}}