{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:18:42Z","timestamp":1782310722741,"version":"3.54.5"},"reference-count":57,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":824,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL107483"],"award-info":[{"award-number":["HL107483"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1111\/jth.14881","type":"journal-article","created":{"date-parts":[[2020,5,2]],"date-time":"2020-05-02T06:51:05Z","timestamp":1588402265000},"page":"1911-1921","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Therapeutic doses of recombinant factor VIIa in hemophilia generates thrombin in platelet\u2010dependent and \u2010independent mechanisms"],"prefix":"10.1016","volume":"18","author":[{"given":"Shiva","family":"Keshava","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha R.","family":"Pendurthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles T.","family":"Esmon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2099-0585","authenticated-orcid":false,"given":"L. Vijaya Mohan","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/jth.14881_bb0010","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1160\/TH08-07-0434","article-title":"VIIa and its potential therapeutic use in bleeding\u2010associated pathologies","volume":"100","author":"Factor","year":"2008","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.14881_bb0015","doi-asserted-by":"crossref","first-page":"516","DOI":"10.7326\/0003-4819-154-8-201104190-00002","article-title":"Off\u2010label use of recombinant factor VIIa in U.S. hospitals: analysis of hospital records","volume":"154","author":"Logan","year":"2011","journal-title":"Ann Intern Med"},{"key":"10.1111\/jth.14881_bb0020","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1053\/j.seminhematol.2003.11.019","article-title":"Safety profile of recombinant factor VIIa","volume":"41","author":"Roberts","year":"2004","journal-title":"Semin Hematol"},{"key":"10.1111\/jth.14881_bb0025","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/j.1538-7836.2004.00759.x","article-title":"Recombinant factor VIIa: review of efficacy, dosing regimens and safety in patients with congenital and acquired factor VIII or IX inhibitors","volume":"2","author":"Abshire","year":"2004","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14881_bb0030","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.amjsurg.2009.05.026","article-title":"Complications of recombinant activated human coagulation factor VII","volume":"198","author":"Howes","year":"2009","journal-title":"Am J Surg"},{"key":"10.1111\/jth.14881_bb0035","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1182\/blood.V95.4.1330.004k28_1330_1335","article-title":"Inhibition of thrombin generation by the zymogen factor VII: implications for the treatment of hemophilia A by factor VIIa","volume":"95","author":"van't Veer","year":"2000","journal-title":"Blood"},{"key":"10.1111\/jth.14881_bb0040","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1182\/blood.V99.3.923","article-title":"Mechanism of factor VIIa\u2010dependent coagulation in hemophilia blood","volume":"99","author":"Butenas","year":"2002","journal-title":"Blood"},{"key":"10.1111\/jth.14881_bb0045","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1182\/blood-2011-11-393371","article-title":"Unifying the mechanism of recombinant FVIIa action: dose dependence is regulated differently by tissue factor and phospholipids","volume":"120","author":"Shibeko","year":"2012","journal-title":"Blood"},{"key":"10.1111\/jth.14881_bb0050","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1046\/j.1365-2141.1997.4463256.x","article-title":"Platelet activity of high\u2010dose factor VIIa is independent of tissue factor","volume":"99","author":"Monroe","year":"1997","journal-title":"Br J Haematol"},{"key":"10.1111\/jth.14881_bb0055","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1182\/blood-2013-08-522987","article-title":"FVIIa as used pharmacologically is not TF dependent in hemophilia B mice","volume":"123","author":"Feng","year":"2014","journal-title":"Blood"},{"key":"10.1111\/jth.14881_bb0060","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1182\/blood.V75.5.1069.1069","article-title":"Factor VIIa\u2010catalyzed activation of factor X independent of tissue factor: its possible significance for control of hemophilic bleeding by infused factor VIIa","volume":"75","author":"Rao","year":"1990","journal-title":"Blood"},{"issue":"3","key":"10.1111\/jth.14881_bb0065","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/jth.13244","article-title":"Pharmacological concentrations of rFVIIa restore hemostasis independent of tissue factor in antibody\u2010induced hemophilia mice","volume":"14","author":"Keshava","year":"2016","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14881_bb0070","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0037-1963(01)90140-4","article-title":"The action of high\u2010dose factor VIIa (FVIIa) in a cell\u2010based model of hemostasis","volume":"38","author":"Hoffman","year":"2001","journal-title":"Semin Hematol"},{"issue":"Suppl 1","key":"10.1111\/jth.14881_bb0075","first-page":"159","article-title":"Clinical experience with recombinant factor VIIa in patients with thrombocytopenia","volume":"26","author":"Kristensen","year":"1996","journal-title":"Haemostasis"},{"key":"10.1111\/jth.14881_bb0080","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.0958-7578.2005.00564.x","article-title":"Recombinant FVIIa in the management of intracerebral haemorrhage in severe thrombocytopenia unresponsive to platelet\u2010enhancing treatment","volume":"15","author":"Barnes","year":"2005","journal-title":"Transfus Med"},{"key":"10.1111\/jth.14881_bb0085","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1055\/s-0037-1615210","article-title":"Recombinant factor VIIa in severe uremic bleeding","volume":"80","author":"Revesz","year":"1998","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.14881_bb0090","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/00001721-200009000-00010","article-title":"Recombinant factor VIIa treatment of bleeding associated with acute renal failure","volume":"11","author":"Moisescu","year":"2000","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1111\/jth.14881_bb0095","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1182\/blood.V94.11.3951","article-title":"Recombinant factor VIIa is effective for bleeding and surgery in patients with Glanzmann thrombasthenia","volume":"94","author":"Poon","year":"1999","journal-title":"Blood"},{"key":"10.1111\/jth.14881_bb0100","first-page":"655","article-title":"Clinical use of recombinant human activated factor VII (rFVIIa) in the prevention and treatment of bleeding episodes in patients with Glanzmann's thrombasthenia","volume":"3","author":"Poon","year":"2007","journal-title":"Vasc Health Risk Manag"},{"key":"10.1111\/jth.14881_bb0105","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1055\/s-2000-8455","article-title":"The factor VII\u2010platelet interplay: effectiveness of recombinant factor VIIa in the treatment of bleeding in severe thrombocytopathia","volume":"26","author":"Monroe","year":"2000","journal-title":"Semin Thromb Hemost"},{"key":"10.1111\/jth.14881_bb0110","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1182\/blood-2003-07-2287","article-title":"Recombinant factor VIIa restores aggregation of xIIbB3\u2010deficient platelets via tissue factor\u2010independent fibrin generation","volume":"103","author":"Lisman","year":"2004","journal-title":"Blood"},{"key":"10.1111\/jth.14881_bb0115","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1111\/j.1538-7836.2005.01227.x","article-title":"Recombinant factor VIIa enhances platelet adhesion and activation under flow conditions at normal and reduced platelet count","volume":"3","author":"Lisman","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14881_bb0120","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1182\/blood-2002-09-2761","article-title":"Recombinant factor VIIa enhances deposition of platelets with congenital or acquired alpha IIb beta 3 deficiency to endothelial cell matrix and collagen under conditions of flow via tissue factor\u2010independent thrombin generation","volume":"101","author":"Lisman","year":"2003","journal-title":"Blood"},{"key":"10.1111\/jth.14881_bb0125","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1046\/j.1537-2995.2003.00427.x","article-title":"Increased local procoagulant action: a mechanism contributing to the favorable hemostatic effect of recombinant FVIIa in PLT disorders","volume":"43","author":"Galan","year":"2003","journal-title":"Transfusion"},{"key":"10.1111\/jth.14881_bb0130","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1182\/blood-2014-03-565010","article-title":"New insights into the spatiotemporal localization of prothrombinase in vivo","volume":"124","author":"Ivanciu","year":"2014","journal-title":"Blood"},{"key":"10.1111\/jth.14881_bb0135","doi-asserted-by":"crossref","first-page":"11849","DOI":"10.1074\/jbc.M609283200","article-title":"Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium","volume":"282","author":"Ghosh","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.14881_bb0140","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1182\/bloodadvances.2016004143","article-title":"Factor VIIa interaction with EPCR modulates the hemostatic effect of rFVIIa in hemophilia therapy: mode of its action","volume":"1","author":"Keshava","year":"2017","journal-title":"Blood Adv"},{"issue":"9","key":"10.1111\/jth.14881_bb0145","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1111\/jth.14165","article-title":"Human platelets express endothelial protein C receptor, which can be utilized to enhance localization of factor VIIa activity","volume":"16","author":"Fager","year":"2018","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14881_bb0150","doi-asserted-by":"crossref","first-page":"7785","DOI":"10.1021\/bi00420a030","article-title":"Amino acid sequence and posttranslational modifications of human factor VIIa from plasma and transfected baby hamster kidney cells","volume":"27","author":"Thim","year":"1988","journal-title":"Biochemistry"},{"key":"10.1111\/jth.14881_bb0155","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0021-9258(19)70127-6","article-title":"Isolation and characterization of human factor VII. Activation of factor VII by factor Xa","volume":"256","author":"Bajaj","year":"1981","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.14881_bb0160","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1111\/j.1538-7836.2005.01385.x","article-title":"Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin","volume":"3","author":"Li","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14881_bb0165","doi-asserted-by":"crossref","first-page":"10212","DOI":"10.1073\/pnas.93.19.10212","article-title":"The endothelial cell protein C receptor augments protein C activation by the thrombin\u2010thrombomodulin complex","volume":"93","author":"Stearns\u2010Kurosawa","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/jth.14881_bb0170","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1182\/blood-2005-01-0406","article-title":"Extraembryonic expression of EPCR is essential for embryonic viability","volume":"106","author":"Li","year":"2005","journal-title":"Blood"},{"key":"10.1111\/jth.14881_bb0175","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1182\/blood-2014-04-567297","article-title":"The endothelial protein C receptor enhances hemostasis of FVIIa administration in hemophilic mice in vivo","volume":"124","author":"Pavani","year":"2014","journal-title":"Blood"},{"key":"10.1111\/jth.14881_bb0180","series-title":"Recombinant Factor VIIa: Clinical Uses, Dosing, and Adverse Effects","author":"Hoffman","year":"2019"},{"issue":"Suppl 1","key":"10.1111\/jth.14881_bb0185","first-page":"S61","article-title":"Activated factor VII activates factors IX and X on the surface of activated platelets: thoughts on the mechanism of action of high\u2010dose activated factor VII","volume":"9","author":"Hoffman","year":"1998","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"Suppl 1","key":"10.1111\/jth.14881_bb0190","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S0268-960X(03)90000-2","article-title":"A cell\u2010based model of coagulation and the role of factor VIIa","volume":"17","author":"Hoffman","year":"2003","journal-title":"Blood Rev"},{"key":"10.1111\/jth.14881_bb0195","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1182\/blood-2008-02-139113","article-title":"The glycoprotein Ib\u2010IX\u2010V complex contributes to tissue factor\u2010independent thrombin generation by recombinant factor VIIa on the activated platelet surface","volume":"112","author":"Weeterings","year":"2008","journal-title":"Blood"},{"key":"10.1111\/jth.14881_bb0200","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s00018-005-4527-3","article-title":"Surface exposure of phosphatidylserine in pathological cells","volume":"62","author":"Zwaal","year":"2005","journal-title":"Cell Mol Life Sci"},{"key":"10.1111\/jth.14881_bb0205","doi-asserted-by":"crossref","first-page":"5120","DOI":"10.1021\/bi9626160","article-title":"Comparison of naturally occurring vitamin K\u2010dependent proteins: correlation of amino acid sequences and membrane binding properties suggests a membrane contact site","volume":"36","author":"McDonald","year":"1997","journal-title":"Biochemistry"},{"key":"10.1111\/jth.14881_bb0210","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1021\/bi00604a017","article-title":"Interaction of vitamin K dependent proteins with membranes","volume":"17","author":"Nelsestuen","year":"1978","journal-title":"Biochemistry"},{"key":"10.1111\/jth.14881_bb0215","doi-asserted-by":"crossref","first-page":"5545","DOI":"10.1021\/bi4006368","article-title":"Factor VII and protein C are phosphatidic acid\u2010binding proteins","volume":"52","author":"Tavoosi","year":"2013","journal-title":"Biochemistry"},{"key":"10.1111\/jth.14881_bb0220","doi-asserted-by":"crossref","first-page":"160","DOI":"10.2337\/diacare.14.2.160","article-title":"Endothelium and regulation of coagulation","volume":"14","author":"Stern","year":"1991","journal-title":"Diabetes Care"},{"key":"10.1111\/jth.14881_bb0225","first-page":"336","article-title":"Interactions of neutrophils and coagulation proteins","volume":"34","author":"Gillis","year":"1997","journal-title":"Semin Hematol"},{"key":"10.1111\/jth.14881_bb0230","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1046\/j.1538-7836.2003.00089.x","article-title":"The participation of leukocytes in coagulant reactions","volume":"1","author":"Bouchard","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14881_bb0235","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1111\/j.1538-7836.2005.01328.x","article-title":"Spatial and temporal dynamics of the endothelium","volume":"3","author":"Aird","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14881_bb0240","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2019.1688936","article-title":"Extracellular vesicles and coagulation in blood from healthy humans revisited","volume":"8","author":"Berckmans","year":"2019","journal-title":"J Extracell Vesicles"},{"key":"10.1111\/jth.14881_bb0245","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1160\/TH11-09-0672","article-title":"Factor VIIa binding to endothelial cell protein C receptor: differences between mouse and human systems","volume":"107","author":"Sen","year":"2012","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.14881_bb0250","doi-asserted-by":"crossref","first-page":"8364","DOI":"10.1074\/jbc.M010572200","article-title":"Identification of the protein C\/activated protein C binding sites on the endothelial cell protein C receptor. Implications for a novel mode of ligand recognition by a major histocompatibility complex class 1\u2010type receptor","volume":"276","author":"Liaw","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.14881_bb0255","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1182\/blood-2009-03-208900","article-title":"Endothelial cell protein C receptor cellular localization and trafficking: potential functional implications","volume":"114","author":"Nayak","year":"2009","journal-title":"Blood"},{"key":"10.1111\/jth.14881_bb0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0059304","article-title":"Rab GTPases regulate endothelial cell protein C receptor\u2010mediated endocytosis and trafficking of factor VIIa","volume":"8","author":"Nayak","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1111\/jth.14881_bb0265","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1111\/j.1538-7836.2012.04917.x","article-title":"Endothelial cell protein C receptor\u2010mediated redistribution and tissue\u2010level accumulation of factor VIIa","volume":"10","author":"Clark","year":"2012","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.14881_bb0270","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1007\/s00277-005-1080-y","article-title":"Use of recombinant factor VIIa in the management of severe bleeding episodes in patients with Bernard\u2010Soulier syndrome","volume":"84","author":"Ozelo","year":"2005","journal-title":"Ann Hematol"},{"key":"10.1111\/jth.14881_bb0275","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/ajh.10056","article-title":"Effective hemostasis with rFVIIa treatment in two patients with severe thrombocytopenia and life\u2010threatening hemorrhage","volume":"69","author":"Gerotziafas","year":"2002","journal-title":"Am J Hematol"},{"key":"10.1111\/jth.14881_bb0280","first-page":"981","article-title":"A patient with Glanzmann thrombasthenia and epistaxis successfully treated with recombinant factor VIIa","volume":"75","author":"Tengborn","year":"1996","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.14881_bb0285","first-page":"24","article-title":"The use of recombinant activated factor VII in platelet disorders: a critical review of the literature","volume":"7","author":"Franchini","year":"2009","journal-title":"Blood Transfus"},{"issue":"Suppl 4","key":"10.1111\/jth.14881_bb0290","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1365-2516.2012.02842.x","article-title":"Treatment of inherited platelet disorders","volume":"18","author":"Seligsohn","year":"2012","journal-title":"Haemophilia"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.14881","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.14881","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jth.14881","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622016105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622016105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.14881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:28:05Z","timestamp":1761535685000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622016105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":57,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S1538783622016105"],"URL":"https:\/\/doi.org\/10.1111\/jth.14881","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic doses of recombinant factor VIIa in hemophilia generates thrombin in platelet\u2010dependent and \u2010independent mechanisms","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/jth.14881","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}