{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:44:37Z","timestamp":1790840677926,"version":"4.1.0"},"reference-count":110,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T00:00:00Z","timestamp":1667692800000},"content-version":"vor","delay-in-days":705,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL082808"],"award-info":[{"award-number":["HL082808"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL134241"],"award-info":[{"award-number":["HL134241"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL143794"],"award-info":[{"award-number":["HL143794"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL146299"],"award-info":[{"award-number":["HL146299"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1111\/jth.15035","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T15:24:15Z","timestamp":1596209055000},"page":"3131-3141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["Structure\u2010function of platelet glycoprotein Ib\u2010IX"],"prefix":"10.1016","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7791-4562","authenticated-orcid":false,"given":"M. Edward","family":"Quach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5806-5080","authenticated-orcid":false,"given":"Renhao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/jth.15035_bb0010","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1182\/blood.V88.5.1525.1525","article-title":"Platelets and shear stress","volume":"88","author":"Kroll","year":"1996","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0015","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1182\/blood-2012-04-416594","article-title":"The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways","volume":"120","author":"Burkhart","year":"2012","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0020","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1182\/blood-2006-05-024091","article-title":"Glycoprotein Ibalpha forms disulfide bonds with 2 glycoprotein Ibbeta subunits in the resting platelet","volume":"109","author":"Luo","year":"2007","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0025","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/00001721-199402000-00013","article-title":"The platelet glycoprotein Ib\u2010IX complex","volume":"5","author":"Lopez","year":"1994","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1111\/jth.15035_bb0030","doi-asserted-by":"crossref","first-page":"12851","DOI":"10.1016\/S0021-9258(18)42354-X","article-title":"Efficient plasma membrane expression of a functional platelet glycoprotein Ib\u2010IX complex requires the presence of its three subunits","volume":"267","author":"Lopez","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15035_bb0035","doi-asserted-by":"crossref","first-page":"23050","DOI":"10.1074\/jbc.M600924200","article-title":"The transmembrane domain of glycoprotein Ib\u03b2 is critical to efficient expression of glycoprotein Ib\u2010IX complex in the plasma membrane","volume":"281","author":"Mo","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15035_bb0040","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1111\/j.1538-7836.2012.04841.x","article-title":"Transmembrane domains are critical to the interaction between platelet glycoprotein V and glycoprotein Ib\u2010IX complex","volume":"10","author":"Mo","year":"2012","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.15035_bb0045","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1126\/science.107355","article-title":"Structures of glycoprotein Iba and its complex with von Willebrand factor A1 domain","volume":"297","author":"Huizinga","year":"2002","journal-title":"Science"},{"key":"10.1111\/jth.15035_bb0050","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1365-2141.1969.tb00402.x","article-title":"Congenital thrombocytopenia with giant platelets: a defect in the platelet membrane","volume":"16","author":"Grottum","year":"1969","journal-title":"Br J Haematol"},{"key":"10.1111\/jth.15035_bb0055","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1182\/blood-2014-07-589507","article-title":"Identification of a juxtamembrane mechanosensitive domain in the platelet mechanosensor glycoprotein Ib\u2010IX complex","volume":"125","author":"Zhang","year":"2015","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0060","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1016\/j.bpj.2019.03.037","article-title":"Force\u2010regulated refolding of the mechanosensory domain in the platelet glycoprotein Ib\u2010IX complex","volume":"116","author":"Zhang","year":"2019","journal-title":"Biophys J"},{"key":"10.1111\/jth.15035_bb0065","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/01.RES.0000143899.73453.11","article-title":"Tumor necrosis factor\u2010\u03b1\u2010converting enzyme (ADAM17) mediates GPIb\u03b1 shedding from platelets in vitro and in vivo","volume":"95","author":"Bergmeier","year":"2004","journal-title":"Circ Res"},{"key":"10.1111\/jth.15035_bb0070","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1111\/j.1538-7836.2007.02590.x","article-title":"Controlled shedding of platelet glycoprotein (GP)VI and GPIb\u2010IX\u2010V by ADAM family metalloproteinases","volume":"5","author":"Gardiner","year":"2007","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.15035_bb0075","doi-asserted-by":"crossref","first-page":"12863","DOI":"10.1038\/ncomms12863","article-title":"Platelet clearance via shear\u2010induced unfolding of a membrane mechanoreceptor","volume":"7","author":"Deng","year":"2016","journal-title":"Nat Commun"},{"key":"10.1111\/jth.15035_bb0080","doi-asserted-by":"crossref","first-page":"5292","DOI":"10.1182\/blood-2011-05-356253","article-title":"Quaternary organization of GPIb\u2010IX complex and insights into Bernard\u2010Soulier syndrome revealed by the structures of GPIb\u03b2 and a GPIb\u03b2\/GPIX chimera","volume":"118","author":"McEwan","year":"2011","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0085","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/jth.12144","article-title":"The organizing principle of the platelet glycoprotein Ib\u2010IX\u2010V complex","volume":"11","author":"Li","year":"2013","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.15035_bb0090","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jmb.2008.07.037","article-title":"Specific heteromeric association of four transmembrane peptides derived from platelet glycoprotein Ib\u2010IX complex","volume":"382","author":"Luo","year":"2008","journal-title":"J Mol Biol"},{"key":"10.1111\/jth.15035_bb0095","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/jth.12437","article-title":"Analysis of inter\u2010subunit contacts reveals the structural malleability of extracellular domains in platelet glycoprotein Ib\u2010IX complex","volume":"12","author":"Zhou","year":"2014","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.15035_bb0100","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/jth.14684","article-title":"Unaccompanied mechanosensory domain mediates low expression of glycoprotein Ibalpha: implications for Bernard\u2010Soulier syndrome","volume":"18","author":"Tao","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.15035_bb0105","first-page":"3217","article-title":"Sur une nouvelle vari\u00e9t\u00e9 de dystrophie thrombocytaire\u2010h\u00e9morragipare cong\u00e9nitale","volume":"24","author":"Bernard","year":"1948","journal-title":"Sem Hop"},{"key":"10.1111\/jth.15035_bb0110","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1172\/JCI108251","article-title":"Platelet membrane glycoproteins implicated in ristocetin\u2010induced aggregation. Studies of the proteins on platelets from patients with Bernard\u2010Soulier syndrome and von Willebrand's disease","volume":"57","author":"Jenkins","year":"1976","journal-title":"J Clin Invest"},{"key":"10.1111\/jth.15035_bb0115","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1073\/pnas.050582097","article-title":"Generation and rescue of a murine model of platelet dysfunction: the Bernard\u2010Soulier syndrome","volume":"97","author":"Ware","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/jth.15035_bb0120","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1182\/blood-2004-03-1127","article-title":"Genetic deletion of mouse platelet glycoprotein Ib\u03b2 produces a Bernard\u2010Soulier phenotype with increased \u03b1\u2010granule size","volume":"104","author":"Kato","year":"2004","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0125","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1182\/blood-2010-01-266080","article-title":"A central role of GPIb\u2010IX in the procoagulant function of platelets that is independent of the 45\u2010kDa GPIb\u03b1 N\u2010terminal extracellular domain","volume":"116","author":"Ravanat","year":"2010","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0130","doi-asserted-by":"crossref","first-page":"31449","DOI":"10.1074\/jbc.273.47.31449","article-title":"Synthesis, assembly, and intracellular transport of the platelet glycoprotein Ib\u2010IX\u2010V complex","volume":"273","author":"Dong","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15035_bb0135","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1042\/bj3580295","article-title":"Biosynthesis and intracellular post\u2010translational processing of normal and mutant platelet glycoprotein GPIb\u2010IX","volume":"358","author":"Ulsemer","year":"2001","journal-title":"Biochem J"},{"key":"10.1111\/jth.15035_bb0140","doi-asserted-by":"crossref","first-page":"7136","DOI":"10.1182\/blood-2011-01-330464","article-title":"Heat\u2010shock protein gp96\/grp94 is an essential chaperone for the platelet glycoprotein Ib\u2010IX\u2010V complex","volume":"117","author":"Staron","year":"2011","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0145","doi-asserted-by":"crossref","first-page":"16143","DOI":"10.1073\/pnas.1208253109","article-title":"Platelet biogenesis and functions require correct protein O\u2010glycosylation","volume":"109","author":"Wang","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/jth.15035_bb0150","doi-asserted-by":"crossref","first-page":"8360","DOI":"10.1073\/pnas.1707662114","article-title":"Sialylation on O\u2010glycans protects platelets from clearance by liver Kupffer cells","volume":"114","author":"Li","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/jth.15035_bb0155","doi-asserted-by":"crossref","DOI":"10.3324\/haematol.2019.240440","article-title":"Desialylation of O\u2010glycans on glycoprotein Ibalpha drives receptor signaling and platelet clearance","author":"Wang","year":"2020","journal-title":"Haematologica"},{"key":"10.1111\/jth.15035_bb0160","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1182\/blood-2011-05-355628","article-title":"Desialylation accelerates platelet clearance after refrigeration and initiates GPIb\u03b1 metalloproteinase\u2010mediated cleavage in mice","volume":"119","author":"Jansen","year":"2012","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0165","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1538-7836.2007.02298.x","article-title":"Trp207Gly in platelet glycoprotein Ib\u03b1 is a novel mutation that disrupts the connection between the leucine\u2010rich repeat domain and the disulfide loop structure and causes Bernard\u2010Soulier syndrome","volume":"5","author":"Rosenberg","year":"2007","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.15035_bb0170","doi-asserted-by":"crossref","first-page":"e160","DOI":"10.1016\/j.thromres.2013.01.014","article-title":"Novel Bernard\u2010Soulier syndrome variants caused by compound heterozygous mutations (case I) or a cytoplasmic tail truncation (case II) of GPIbalpha","volume":"131","author":"Yamamoto","year":"2013","journal-title":"Thromb Res"},{"key":"10.1111\/jth.15035_bb0175","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1182\/blood.V97.5.1330","article-title":"Autosomal dominant macrothrombocytopenia in Italy is most frequently a type of heterozygous Bernard\u2010Soulier syndrome","volume":"97","author":"Savoia","year":"2001","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0180","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1182\/blood-2016-08-732248","article-title":"Rare variants in GP1BB are responsible for autosomal dominant macrothrombocytopenia","volume":"129","author":"Sivapalaratnam","year":"2017","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0185","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/pr.2015.216","article-title":"Effect of 22q11.2 deletion on bleeding and transfusion utilization in children with congenital heart disease undergoing cardiac surgery","volume":"79","author":"Brenner","year":"2016","journal-title":"Pediatr Res"},{"key":"10.1111\/jth.15035_bb0190","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/jth.14357","article-title":"Hemizygosity for the gene encoding glycoprotein Ibbeta is not responsible for macrothrombocytopenia and bleeding in patients with 22q11 deletion syndrome","volume":"17","author":"Zwifelhofer","year":"2019","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.15035_bb0195","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1055\/s-0033-1353442","article-title":"Platelet\u2010type von Willebrand disease: new insights into the molecular pathophysiology of a unique platelet defect","volume":"39","author":"Othman","year":"2013","journal-title":"Semin Thromb Hemost"},{"key":"10.1111\/jth.15035_bb0200","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.1182\/blood-2009-03-210823","article-title":"Visualizing the von Willebrand factor\/glycoprotein Ib\u2010IX axis with a platelet\u2010type von Willebrand disease mutation","volume":"114","author":"Guerrero","year":"2009","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0205","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.3324\/haematol.2018.200378","article-title":"Mechanisms of thrombocytopenia in platelet\u2010type von Willebrand disease","volume":"104","author":"Bury","year":"2019","journal-title":"Haematologica"},{"key":"10.1111\/jth.15035_bb0210","doi-asserted-by":"crossref","first-page":"23327","DOI":"10.1074\/jbc.M401659200","article-title":"Crystal structure of the wild\u2010type von Willebrand factor A1\u2010glycoprotein Iba complex reveals conformation differences with a complex bearing von Willebrand disease mutations","volume":"279","author":"Dumas","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15035_bb0215","doi-asserted-by":"crossref","first-page":"4330","DOI":"10.1182\/blood-2002-09-2942","article-title":"Identification and functional characterization of a novel 27\u2010bp deletion in the macroglycopeptide\u2010coding region of the GPIb\u03b1 gene resulting in platelet\u2010type von Willebrand disease","volume":"105","author":"Othman","year":"2005","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0220","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1055\/s-0037-1613274","article-title":"The mucin\u2010like macroglycopeptide region of glycoprotein Iba is required for cell adhesion to immobilized von Willebrand factor (VWF) under flow but not for static VWF binding","volume":"88","author":"Li","year":"2002","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.15035_bb0225","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0092-8674(00)81607-4","article-title":"Specific synergy of multiple substrate\u2010receptor interactions in platelet thrombus formation under flow","volume":"94","author":"Savage","year":"1998","journal-title":"Cell"},{"key":"10.1111\/jth.15035_bb0230","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0092-8674(00)80983-6","article-title":"Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor","volume":"84","author":"Savage","year":"1996","journal-title":"Cell"},{"key":"10.1111\/jth.15035_bb0235","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1084\/jem.20020143","article-title":"Localization of the adhesion receptor glycoprotein Ib\u2010IX\u2010V complex to lipid rafts is required for platelet adhesion and activation","volume":"196","author":"Shrimpton","year":"2002","journal-title":"J Exp Med"},{"key":"10.1111\/jth.15035_bb0240","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1182\/blood.V96.7.2520","article-title":"Identification of critical antigen\u2010specific mechanisms in the development of immune thrombocytopenic purpura in mice","volume":"96","author":"Nieswandt","year":"2000","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0245","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1161\/01.ATV.20.5.1347","article-title":"Antithrombotic effect of platelet glycoprotein Ib\u2010blocking monoclonal antibody Fab fragments in nonhuman primates","volume":"20","author":"Cauwenberghs","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/jth.15035_bb0250","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1160\/TH14-03-0217","article-title":"Glycoprotein Ibalpha clustering induces macrophage\u2010mediated platelet clearance in the liver","volume":"113","author":"Yan","year":"2015","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.15035_bb0255","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/jth.13221","article-title":"Dimerization of glycoprotein Ib\u03b1 is not sufficient to induce platelet clearance","volume":"14","author":"Liang","year":"2016","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.15035_bb0260","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1161\/ATVBAHA.112.301013","article-title":"Targeting platelet GPIb\u03b2 reduces platelet adhesion, GPIb signaling and thrombin generation and prevents arterial thrombosis","volume":"33","author":"Maurer","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/jth.15035_bb0265","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.15447","article-title":"Cooperative unfolding of distinctive mechanoreceptor domains transduces force into signals","volume":"5","author":"Ju","year":"2016","journal-title":"Elife"},{"key":"10.1111\/jth.15035_bb0270","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1182\/blood-2002-03-0997","article-title":"Amelioration of the macrothrombocytopenia associated with the murine Bernard\u2010Soulier syndrome","volume":"100","author":"Kanaji","year":"2002","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0275","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/jth.12524","article-title":"Association of autoantibody specificity and response to intravenous immunoglobulin G therapy in immune thrombocytopenia: a multicenter cohort study","volume":"12","author":"Peng","year":"2014","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.15035_bb0280","doi-asserted-by":"crossref","first-page":"7737","DOI":"10.1038\/ncomms8737","article-title":"Desialylation is a mechanism of Fc\u2010independent platelet clearance and a therapeutic target in immune thrombocytopenia","volume":"6","author":"Li","year":"2015","journal-title":"Nat Commun"},{"key":"10.1111\/jth.15035_bb0285","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1182\/blood-2017-05-784975","article-title":"Fc\u2010independent immune thrombocytopenia via mechanomolecular signaling in platelets","volume":"131","author":"Quach","year":"2018","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0290","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1056\/NEJM195807242590402","article-title":"Hematologic complications arising during ristocetin therapy; relation between dose and toxicity","volume":"259","author":"Gangarosa","year":"1958","journal-title":"N Engl J Med"},{"key":"10.1111\/jth.15035_bb0295","first-page":"443","article-title":"Thrombotic thrombocytopenia with von Willebrand factor deficiency induced by botrocetin. An animal model","volume":"59","author":"Sanders","year":"1988","journal-title":"Lab Invest"},{"key":"10.1111\/jth.15035_bb0300","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1182\/blood-2013-06-498303","article-title":"Willebrand disease: advances in pathogenetic understanding, diagnosis, and therapy","volume":"122","author":"von Lillicrap","year":"2013","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0305","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1182\/blood-2013-03-493312","article-title":"Accelerated uptake of VWF\/platelet complexes in macrophages contributes to VWD type 2B\u2010associated thrombocytopenia","volume":"122","author":"Casari","year":"2013","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0310","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1182\/blood-2015-10-636480","article-title":"Acquired von Willebrand syndrome associated with left ventricular assist device","volume":"127","author":"Nascimbene","year":"2016","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0315","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.healun.2018.03.013","article-title":"Acquired von Willebrand syndrome and impaired platelet function during venovenous extracorporeal membrane oxygenation: Rapid onset and fast recovery","volume":"37","author":"Kalbhenn","year":"2018","journal-title":"J Heart Lung Transplant"},{"key":"10.1111\/jth.15035_bb0320","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000349","article-title":"Severe Plasmodium falciparum malaria is associated with circulating ultra\u2010large von Willebrand multimers and ADAMTS13 inhibition","volume":"5","author":"Larkin","year":"2009","journal-title":"PLoS Pathog"},{"key":"10.1111\/jth.15035_bb0325","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007500","article-title":"Desialylation of platelets induced by Von Willebrand Factor is a novel mechanism of platelet clearance in dengue","volume":"15","author":"Riswari","year":"2019","journal-title":"PLoS Pathog"},{"key":"10.1111\/jth.15035_bb0330","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1160\/TH05-06-0403","article-title":"The death of human platelets during incubation in citrated plasma involves shedding of CD42b and aggregation of dead platelets","volume":"95","author":"Hartley","year":"2006","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.15035_bb0335","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1182\/blood-2003-04-1305","article-title":"Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro\u2010aged or \u2010injured mouse platelets","volume":"102","author":"Bergmeier","year":"2003","journal-title":"Blood"},{"issue":"9","key":"10.1111\/jth.15035_bb0340","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1161\/ATVBAHA.116.307639","article-title":"Inhibiting GPIb\u03b1 shedding preserves post\u2010transfusion recovery and hemostatic function of platelets after prolonged storage","volume":"36","author":"Chen","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/jth.15035_bb0345","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1365-2141.1972.tb08790.x","article-title":"Neuraminidase\u2010induced thrombocytopenia in rats","volume":"22","author":"Choi","year":"1972","journal-title":"Br J Haematol"},{"key":"10.1111\/jth.15035_bb0350","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1161\/ATVBAHA.117.310062","article-title":"Refrigeration\u2010induced binding of von Willebrand factor facilitates fast clearance of refrigerated platelets","volume":"37","author":"Chen","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/jth.15035_bb0355","doi-asserted-by":"crossref","first-page":"20218","DOI":"10.1073\/pnas.1313905110","article-title":"Inducing host protection in pneumococcal sepsis by preactivation of the Ashwell\u2010Morell receptor","volume":"110","author":"Grewal","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/jth.15035_bb0360","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190723","article-title":"Macrophage galactose lectin is critical for Kupffer cells to clear aged platelets","volume":"217","author":"Deppermann","year":"2020","journal-title":"J Exp Med"},{"key":"10.1111\/jth.15035_bb0365","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1083\/jcb.147.5.1085","article-title":"Analysis of the roles of 14\u20103\u20103 in the platelet glycoprotein Ib\u2010IX\u2010mediated activation of integrin \u03b1IIb\u03b23 using a reconstituted mammalian cell expression model","volume":"147","author":"Gu","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1111\/jth.15035_bb0370","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1182\/blood-2002-02-0514","article-title":"Sequential cytoplasmic calcium signals in a 2\u2010stage platelet activation process induced by the glycoprotein Ibalpha mechanoreceptor","volume":"100","author":"Mazzucato","year":"2002","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0375","doi-asserted-by":"crossref","first-page":"16900","DOI":"10.1073\/pnas.0608207103","article-title":"The role of platelet adhesion receptor GPIb\u03b1 far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis","volume":"103","author":"Bergmeier","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/jth.15035_bb0380","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1182\/blood-2005-02-0618","article-title":"Mechanism of platelet adhesion to von Willebrand factor and microparticle formation under high shear stress","volume":"107","author":"Reininger","year":"2006","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0385","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1182\/blood-2005-05-1933","article-title":"Src family kinase\u2010mediated and Erk\u2010mediated thromboxane A2 generation are essential for VWF\/GPIb\u2010induced fibrinogen receptor activation in human platelets","volume":"106","author":"Garcia","year":"2005","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0390","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1182\/blood-2005-04-1667","article-title":"Botrocetin\/VWF\u2010induced signaling through GPIb\u2010IX\u2010V produces TxA2 in an alphaIIbbeta3\u2010 and aggregation\u2010independent manner","volume":"106","author":"Liu","year":"2005","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0395","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1182\/blood-2017-09-742650","article-title":"14\u20133\u20103 proteins in platelet biology and glycoprotein Ib\u2010IX signaling","volume":"131","author":"Chen","year":"2018","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0400","doi-asserted-by":"crossref","first-page":"18287","DOI":"10.1016\/S0021-9258(17)32301-3","article-title":"Association of a phospholipase A2 (14\u20103\u20103 protein) with the platelet glycoprotein Ib\u2010IX complex","volume":"269","author":"Du","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15035_bb0405","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1182\/blood.V91.4.1295","article-title":"Human signaling protein 14\u20103\u20103z interacts with platelet glycoprotein Ib subunits Iba and Ibb","volume":"91","author":"Calverley","year":"1998","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0410","doi-asserted-by":"crossref","first-page":"4580","DOI":"10.1182\/blood-2007-09-111096","article-title":"A functional 14\u20103\u20103\u03b6\u2010independent association of PI3\u2010kinase with glycoprotein Ib\u03b1, the major ligand\u2010binding subunit of the platelet glycoprotein Ib\u2010IX\u2010V complex","volume":"111","author":"Mu","year":"2008","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0415","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1182\/blood-2005-01-0440","article-title":"A critical role for 14\u20103\u20103\u03b6 protein in regulating the VWF binding function of platelet glycoprotein Ib\u2010IX and its therapeutic implications","volume":"106","author":"Dai","year":"2005","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0420","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1161\/CIRCRESAHA.109.204669","article-title":"Identification of a novel 14\u20133\u20103\u03b6 binding site within the cytoplasmic domain of platelet glycoprotein Ib\u03b1 that plays a key role in regulating the von Willebrand factor binding function of glycoprotein Ib\u2010IX","volume":"105","author":"Yuan","year":"2009","journal-title":"Circ Res"},{"key":"10.1111\/jth.15035_bb0425","doi-asserted-by":"crossref","first-page":"33342","DOI":"10.1074\/jbc.M301217200","article-title":"14\u20133\u20103 zeta mediates integrin\u2010induced activation of Cdc42 and Rac. Platelet glycoprotein Ib\u2010IX regulates integrin\u2010induced signaling by sequestering 14\u20133\u20103 zeta","volume":"278","author":"Bialkowska","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15035_bb0430","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1182\/blood-2002-06-1847","article-title":"Role of the intracellular domains of GPIb in controlling the adhesive properties of the platelet GPIb\/V\/IX complex","volume":"101","author":"Perrault","year":"2003","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0435","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1074\/jbc.274.10.6097","article-title":"Glycoprotein (GP) Ib\u2010IX\u2010transfected cells roll on a von Willebrand factor matrix under flow. Importance of the GPib\/actin\u2010binding protein (ABP\u2010280) interaction in maintaining adhesion under high shear","volume":"274","author":"Cranmer","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15035_bb0440","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.3324\/haematol.2011.059956","article-title":"Arachidonic acid depletion extends survival of cold\u2010stored platelets by interfering with the [glycoprotein Ibalpha\u201314\u20103\u20103zeta] association","volume":"97","author":"van der Wal","year":"2012","journal-title":"Haematologica"},{"key":"10.1111\/jth.15035_bb0445","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1538-7836.2009.03653.x","article-title":"The glycoprotein Ib\u03b1\u2010von Willebrand factor interaction induces platelet apoptosis","volume":"8","author":"Li","year":"2010","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.15035_bb0450","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1084\/jem.192.2.193","article-title":"Platelet glycoprotein Ib\u03b1 is a counterreceptor for the leukocyte integrin Mac\u20101 (CD11b\/CD18)","volume":"192","author":"Simon","year":"2000","journal-title":"J Exp Med"},{"key":"10.1111\/jth.15035_bb0455","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1161\/CIRCULATIONAHA.105.571315","article-title":"Leukocyte engagement of platelet glycoprotein Ibalpha via the integrin Mac\u20101 is critical for the biological response to vascular injury","volume":"112","author":"Wang","year":"2005","journal-title":"Circulation"},{"key":"10.1111\/jth.15035_bb0460","article-title":"Leukocyte integrin Mac\u20101 regulates thrombosis via interaction with platelet GPIbalpha","volume":"8","author":"Wang","year":"2017","journal-title":"Nat Commun"},{"key":"10.1111\/jth.15035_bb0465","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.1084183","article-title":"Modulation of a\u2010thrombin function by distinct interactions with platelet glycoprotein Iba","volume":"301","author":"Celikel","year":"2003","journal-title":"Science"},{"key":"10.1111\/jth.15035_bb0470","doi-asserted-by":"crossref","first-page":"4692","DOI":"10.1074\/jbc.M008160200","article-title":"Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par\u20101 on intact platelets","volume":"276","author":"De Candia","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15035_bb0475","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1182\/blood-2015-04-638387","article-title":"Signaling\u2010mediated cooperativity between glycoprotein Ib\u2010IX and protease\u2010activated receptors in thrombin\u2010induced platelet activation","volume":"127","author":"Estevez","year":"2016","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0480","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aad6712","article-title":"Oral thrombin inhibitor aggravates platelet adhesion and aggregation during arterial thrombosis","volume":"8","author":"Petzold","year":"2016","journal-title":"Sci Transl Med"},{"key":"10.1111\/jth.15035_bb0485","doi-asserted-by":"crossref","first-page":"800","DOI":"10.3324\/haematol.2008.001032","article-title":"Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard\u2010Soulier syndrome","volume":"94","author":"Strassel","year":"2009","journal-title":"Haematologica"},{"key":"10.1111\/jth.15035_bb0490","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1182\/blood-2009-03-209205","article-title":"Exposure of human megakaryocytes to high shear rates accelerates platelet production","volume":"114","author":"Dunois\u2010Larde","year":"2009","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0495","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1182\/blood-2009-07-231886","article-title":"Abnormal VWF modifies megakaryocytopoiesis: studies of platelets and megakaryocyte cultures from patients with von Willebrand disease type 2B","volume":"115","author":"Nurden","year":"2010","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0500","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.88643","article-title":"LIM kinase\/cofilin dysregulation promotes macrothrombocytopenia in severe von Willebrand disease\u2010type 2B","volume":"1","author":"Kauskot","year":"2016","journal-title":"JCI Insight"},{"key":"10.1111\/jth.15035_bb0505","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1182\/blood-2017-12-820779","article-title":"GPIbalpha is required for platelet\u2010mediated hepatic thrombopoietin generation","volume":"132","author":"Xu","year":"2018","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0510","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41591-019-0379-5","article-title":"Platelet GPIbalpha is a mediator and potential interventional target for NASH and subsequent liver cancer","volume":"25","author":"Malehmir","year":"2019","journal-title":"Nat Med"},{"key":"10.1111\/jth.15035_bb0515","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0049-3848(95)00113-6","article-title":"Characterization of tumor\u2010induced platelet aggregation: the role of immunorelated GPIb and GPIIb\/IIIa expression by MCF\u20107 breast cancer cells","volume":"79","author":"Oleksowicz","year":"1995","journal-title":"Thromb Res"},{"key":"10.1111\/jth.15035_bb0520","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/ijc.2910390617","article-title":"Tumor\u2010cell\u2010induced platelet aggregation is a glycoprotein\u2010dependent and lipoxygenase\u2010associated process","volume":"39","author":"Bastida","year":"1987","journal-title":"Int J Cancer"},{"key":"10.1111\/jth.15035_bb0525","doi-asserted-by":"crossref","first-page":"9024","DOI":"10.1073\/pnas.0700625104","article-title":"Platelet glycoprotein Ib\u03b1 supports experimental lung metastasis","volume":"104","author":"Jain","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"issue":"Suppl 2","key":"10.1111\/jth.15035_bb0530","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.1016\/S0049-3848(07)70132-9","article-title":"Role of von Willebrand factor in tumor metastasis","volume":"120","author":"Terraube","year":"2007","journal-title":"Thromb Res"},{"key":"10.1111\/jth.15035_bb0535","doi-asserted-by":"crossref","first-page":"13336","DOI":"10.1073\/pnas.96.23.13336","article-title":"Increased thrombin responsiveness in platelets from mice lacking glycoprotein V","volume":"96","author":"Ramakrishnan","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/jth.15035_bb0540","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1182\/blood.V98.2.368","article-title":"Increased thrombogenesis and embolus formation in mice lacking glycoprotein V","volume":"98","author":"Ni","year":"2001","journal-title":"Blood"},{"key":"10.1111\/jth.15035_bb0545","doi-asserted-by":"crossref","first-page":"16952","DOI":"10.1074\/jbc.M008048200","article-title":"Regulation of von Willebrand factor binding to the platelet glycoprotein Ib\u2010IX by a membrane skeleton\u2010dependent inside\u2010out signal","volume":"276","author":"Englund","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15035_bb0550","doi-asserted-by":"crossref","first-page":"47080","DOI":"10.1074\/jbc.M208329200","article-title":"Regulation of glycoprotein Ib\u2010IX\u2010von Willebrand factor interaction by cAMP\u2010dependent protein kinase\u2010mediated phosphorylation at Ser 166 of glycoprotein Ib\u03b2","volume":"277","author":"Bodnar","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15035_bb0555","doi-asserted-by":"crossref","first-page":"10598","DOI":"10.1021\/bi201351d","article-title":"Reconstitution of platelet glycoprotein Ib\u2010IX complex in phospholipid bilayer nanodiscs","volume":"50","author":"Yan","year":"2011","journal-title":"Biochemistry"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.15035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.15035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jth.15035","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622037576?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622037576?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.15035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:27:42Z","timestamp":1761535662000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622037576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":110,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S1538783622037576"],"URL":"https:\/\/doi.org\/10.1111\/jth.15035","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structure\u2010function of platelet glycoprotein Ib\u2010IX","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/jth.15035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}