{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:40:07Z","timestamp":1784014807661,"version":"3.55.0"},"reference-count":99,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T00:00:00Z","timestamp":1667692800000},"content-version":"vor","delay-in-days":735,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000222","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000222","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1111\/jth.15050","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T21:41:42Z","timestamp":1596750102000},"page":"2812-2822","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["Is the COVID\u201019 thrombotic catastrophe complement\u2010connected?"],"prefix":"10.1016","volume":"18","author":[{"given":"Edward M.","family":"Conway","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward L.G.","family":"Pryzdial","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1111\/jth.15050_bb0010","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A novel coronavirus from patients with pneumonia in China, 2019","volume":"382","author":"Zhu","year":"2020","journal-title":"N Engl J Med"},{"issue":"10229","key":"10.1111\/jth.15050_bb0015","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID\u201019 in Wuhan, China: a retrospective cohort study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet"},{"key":"10.1111\/jth.15050_bb0020","doi-asserted-by":"crossref","first-page":"104362","DOI":"10.1016\/j.jcv.2020.104362","article-title":"Coagulation disorders in coronavirus infected patients: COVID\u201019, SARS\u2010CoV\u20101, MERS\u2010CoV and lessons from the past","volume":"127","author":"Giannis","year":"2020","journal-title":"J Clin Virol"},{"key":"10.1111\/jth.15050_bb0025","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.thromres.2020.04.024","article-title":"Venous and arterial thromboembolic complications in COVID\u201019 patients admitted to an academic hospital in Milan, Italy","volume":"191","author":"Lodigiani","year":"2020","journal-title":"Thromb Res"},{"key":"10.1111\/jth.15050_bb0030","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.thromres.2020.04.041","article-title":"Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID\u201019: an updated analysis","volume":"19","author":"Klok","year":"2020","journal-title":"Thromb Res"},{"issue":"10223","key":"10.1111\/jth.15050_bb0035","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"10.1111\/jth.15050_bb0040","doi-asserted-by":"crossref","first-page":"m1091","DOI":"10.1136\/bmj.m1091","article-title":"Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study","volume":"368","author":"Chen","year":"2020","journal-title":"BMJ"},{"key":"10.1111\/jth.15050_bb0045","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.thromres.2020.05.018","article-title":"Incidence of asymptomatic deep vein thrombosis in patients with COVID\u201019 pneumonia and elevated D\u2010dimer levels","volume":"192","author":"Demelo\u2010Rodriguez","year":"2020","journal-title":"Thromb Res"},{"key":"10.1111\/jth.15050_bb0050","article-title":"Autopsy findings and venous thromboembolism in patients with COVID\u201019: a prospective cohort study","author":"Wichmann","year":"2020","journal-title":"Ann Intern Med"},{"issue":"5","key":"10.1111\/jth.15050_bb0055","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/bjh.16727","article-title":"Thromboembolic risk and anticoagulant therapy in COVID\u201019 patients: emerging evidence and call for action","volume":"189","author":"Kollias","year":"2020","journal-title":"Br J Haematol"},{"key":"10.1111\/jth.15050_bb0060","doi-asserted-by":"crossref","DOI":"10.1111\/bph.15094","article-title":"A rational roadmap for SARS\u2010CoV\u20102\/COVID\u201019 pharmacotherapeutic research and development. IUPHAR review","author":"Alexander","year":"2020","journal-title":"Br J Pharmacol"},{"key":"10.1111\/jth.15050_bb0065","doi-asserted-by":"crossref","DOI":"10.1001\/jama.2020.6019","article-title":"Pharmacologic treatments for coronavirus disease 2019 (COVID\u201019): a review","author":"Sanders","year":"2020","journal-title":"JAMA"},{"issue":"10","key":"10.1111\/jth.15050_bb0070","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.2215\/CJN.02210310","article-title":"Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype","volume":"5","author":"Noris","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"issue":"5","key":"10.1111\/jth.15050_bb0075","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1056\/NEJMc0809959","article-title":"Eculizumab for congenital atypical hemolytic\u2010uremic syndrome","volume":"360","author":"Gruppo","year":"2009","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1111\/jth.15050_bb0080","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/ki.2014.423","article-title":"Efficacy and safety of eculizumab in atypical hemolytic uremic syndrome from 2\u2010year extensions of phase 2 studies","volume":"87","author":"Licht","year":"2015","journal-title":"Kidney Int"},{"key":"10.1111\/jth.15050_bb0085","first-page":"1","article-title":"The complement system: an overview","volume":"150","author":"Morgan","year":"2000","journal-title":"Methods Mol Biol"},{"issue":"11","key":"10.1111\/jth.15050_bb0090","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/nbt1342","article-title":"Complement\u2010targeted therapeutics","volume":"25","author":"Ricklin","year":"2007","journal-title":"Nat Biotechnol"},{"issue":"15","key":"10.1111\/jth.15050_bb0095","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1016\/j.molimm.2009.07.006","article-title":"Stringent regulation of complement lectin pathway C3\/C5 convertase by C4b\u2010binding protein (C4BP)","volume":"46","author":"Rawal","year":"2009","journal-title":"Mol Immunol"},{"issue":"9","key":"10.1111\/jth.15050_bb0100","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1096\/fj.02-0737com","article-title":"Regulation by complement C3a and C5a anaphylatoxins of cytokine production in human umbilical vein endothelial cells","volume":"17","author":"Monsinjon","year":"2003","journal-title":"FASEB J"},{"issue":"6","key":"10.1111\/jth.15050_bb0105","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1084\/jem.20041497","article-title":"Platelet activation leads to activation and propagation of the complement system","volume":"201","author":"Del Conde","year":"2005","journal-title":"J Exp Med"},{"issue":"38\u201339","key":"10.1111\/jth.15050_bb0110","first-page":"905","article-title":"Hemolytic\u2010uremic syndrome: bilateral necrosis of the renal cortex in acute acquired hemolytic anemia","volume":"85","author":"Gasser","year":"1955","journal-title":"Schweiz Med Wochenschr"},{"key":"10.1111\/jth.15050_bb0115","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3389\/fped.2014.00097","article-title":"Extra\u2010renal manifestations of complement\u2010mediated thrombotic microangiopathies","volume":"2","author":"Hofer","year":"2014","journal-title":"Front Pediatr"},{"issue":"9","key":"10.1111\/jth.15050_bb0120","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1136\/jcp.2008.056317","article-title":"Complement deficiency and disease","volume":"61","author":"Unsworth","year":"2008","journal-title":"J Clin Pathol"},{"issue":"Pt 1","key":"10.1111\/jth.15050_bb0125","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1042\/bst0320021","article-title":"Proteases of the complement system","volume":"32","author":"Sim","year":"2004","journal-title":"Biochem Soc Trans"},{"issue":"4","key":"10.1111\/jth.15050_bb0130","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1681\/ASN.2004100861","article-title":"Hemolytic uremic syndrome","volume":"16","author":"Noris","year":"2005","journal-title":"J Am Soc Nephrol"},{"issue":"20","key":"10.1111\/jth.15050_bb0135","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.1182\/blood-2009-03-205096","article-title":"Platelet\u2010associated complement factor H in healthy persons and patients with atypical HUS","volume":"114","author":"Licht","year":"2009","journal-title":"Blood"},{"issue":"4","key":"10.1111\/jth.15050_bb0140","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1056\/NEJMoa0810739","article-title":"Thrombomodulin mutations in atypical hemolytic\u2010uremic syndrome","volume":"361","author":"Delvaeye","year":"2009","journal-title":"N Engl J Med"},{"issue":"21","key":"10.1111\/jth.15050_bb0145","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1182\/blood-2014-09-600411","article-title":"Eculizumab reduces complement activation, inflammation, endothelial damage, thrombosis, and renal injury markers in aHUS","volume":"125","author":"Cofiell","year":"2015","journal-title":"Blood"},{"issue":"2","key":"10.1111\/jth.15050_bb0150","doi-asserted-by":"crossref","first-page":"7053","DOI":"10.4081\/hr.2017.7053","article-title":"Atypical hemolytic uremic syndrome: a brief review","volume":"9","author":"Zhang","year":"2017","journal-title":"Hematol Rep"},{"key":"10.1111\/jth.15050_bb0155","doi-asserted-by":"crossref","first-page":"17028","DOI":"10.1038\/nrdp.2017.28","article-title":"Paroxysmal nocturnal haemoglobinuria","volume":"3","author":"Hill","year":"2017","journal-title":"Nat Rev Dis Primers"},{"issue":"25","key":"10.1111\/jth.15050_bb0160","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1182\/blood-2012-09-311381","article-title":"Thrombosis in paroxysmal nocturnal hemoglobinuria","volume":"121","author":"Hill","year":"2013","journal-title":"Blood"},{"issue":"19","key":"10.1111\/jth.15050_bb0165","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1093\/eurheartj\/ehaa254","article-title":"Acute pulmonary embolism and COVID\u201019 pneumonia: a random association?","volume":"41","author":"Danzi","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1111\/jth.15050_bb0170","article-title":"Pulmonary and cardiac pathology in Covid\u201019: the first autopsy series from New Orleans","author":"Fox","year":"2020","journal-title":"MedRxiv (preprint, not peer\u2010reviewed)"},{"key":"10.1111\/jth.15050_bb0175","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.thromres.2020.04.013","article-title":"Incidence of thrombotic complications in critically ill ICU patients with COVID\u201019","volume":"191","author":"Klok","year":"2020","journal-title":"Thromb Res"},{"issue":"7","key":"10.1111\/jth.15050_bb0180","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3949\/ccjm.87a.ccc008","article-title":"Cytokine storm and the prospects for immunotherapy with COVID\u201019","volume":"87","author":"Calabrese","year":"2020","journal-title":"Cleve Clin J Med"},{"issue":"Suppl 1","key":"10.1111\/jth.15050_bb0185","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1111\/jth.12950","article-title":"Reincarnation of ancient links between coagulation and complement","volume":"13","author":"Conway","year":"2015","journal-title":"J Thromb Haemost"},{"issue":"3","key":"10.1111\/jth.15050_bb0190","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/MBC.0000000000000720","article-title":"Complement\u2010coagulation connections","volume":"29","author":"Conway","year":"2018","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"2","key":"10.1111\/jth.15050_bb0195","doi-asserted-by":"crossref","first-page":"885","DOI":"10.4049\/jimmunol.1102916","article-title":"Mannose\u2010binding lectin\u2010associated serine protease\u20101 is a significant contributor to coagulation in a murine model of occlusive thrombosis","volume":"188","author":"La Bonte","year":"2012","journal-title":"J Immunol"},{"issue":"1\u20132","key":"10.1111\/jth.15050_bb0200","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.imbio.2010.02.005","article-title":"Mannose\u2010binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation","volume":"216","author":"Takahashi","year":"2011","journal-title":"Immunobiology"},{"issue":"9","key":"10.1111\/jth.15050_bb0205","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.bbapap.2008.03.020","article-title":"The action of MBL\u2010associated serine protease 1 (MASP1) on factor XIII and fibrinogen","volume":"1784","author":"Krarup","year":"2008","journal-title":"Biochim Biophys Acta"},{"issue":"7","key":"10.1111\/jth.15050_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0000623","article-title":"Simultaneous activation of complement and coagulation by MBL\u2010associated serine protease 2","volume":"2","author":"Krarup","year":"2007","journal-title":"PLoS One"},{"key":"10.1111\/jth.15050_bb0215","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1126\/science.145.3638.1310","article-title":"Waterfall sequence for intrinsic blood clotting","volume":"145","author":"Davie","year":"1964","journal-title":"Science"},{"issue":"8","key":"10.1111\/jth.15050_bb0220","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1182\/blood-2009-01-199117","article-title":"Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid (aPL) antibodies","volume":"114","author":"Seshan","year":"2009","journal-title":"Blood"},{"issue":"12","key":"10.1111\/jth.15050_bb0225","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1182\/blood-2012-10-460493","article-title":"Rapid activation of monocyte tissue factor by antithymocyte globulin is dependent on complement and protein disulfide isomerase","volume":"121","author":"Langer","year":"2013","journal-title":"Blood"},{"issue":"4","key":"10.1111\/jth.15050_bb0230","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1182\/blood.V68.4.875.875","article-title":"Complement proteins C5b\u20139 stimulate procoagulant activity through platelet prothrombinase","volume":"68","author":"Wiedmer","year":"1986","journal-title":"Blood"},{"issue":"10","key":"10.1111\/jth.15050_bb0235","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1111\/jth.14246","article-title":"Tissue factor at the crossroad of coagulation and cell signaling","volume":"16","author":"Zelaya","year":"2018","journal-title":"J Thromb Haemost"},{"issue":"16","key":"10.1111\/jth.15050_bb0240","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1182\/blood-2016-11-749879","article-title":"Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus development","volume":"129","author":"Subramaniam","year":"2017","journal-title":"Blood"},{"issue":"6","key":"10.1111\/jth.15050_bb0245","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nm1419","article-title":"Generation of C5a in the absence of C3: a new complement activation pathway","volume":"12","author":"Huber\u2010Lang","year":"2006","journal-title":"Nat Med"},{"issue":"8","key":"10.1111\/jth.15050_bb0250","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1182\/blood-2012-02-412080","article-title":"Thrombin generates previously unidentified C5 products that support the terminal complement activation pathway","volume":"120","author":"Krisinger","year":"2012","journal-title":"Blood"},{"issue":"Suppl 1","key":"10.1111\/jth.15050_bb0255","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/j.thromres.2014.03.010","article-title":"The procoagulant envelope virus surface: contribution to enhanced infection","volume":"133","author":"Pryzdial","year":"2014","journal-title":"Thromb Res"},{"issue":"25","key":"10.1111\/jth.15050_bb0260","doi-asserted-by":"crossref","first-page":"13510","DOI":"10.1073\/pnas.94.25.13510","article-title":"Coagulation initiated on herpesviruses","volume":"94","author":"Sutherland","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/jth.15050_bb0265","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.1182\/blood-2011-08-376814","article-title":"Tissue factor and glycoprotein C on herpes simplex virus type 1 are protease\u2010activated receptor 2 cofactors that enhance infection","volume":"119","author":"Sutherland","year":"2012","journal-title":"Blood"},{"issue":"3","key":"10.1111\/jth.15050_bb0270","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/jth.14389","article-title":"Virus envelope tissue factor promotes infection in mice","volume":"17","author":"Sutherland","year":"2019","journal-title":"J Thromb Haemost"},{"issue":"5","key":"10.1111\/jth.15050_bb0275","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1093\/infdis\/jiv499","article-title":"Middle East respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4","volume":"213","author":"Li","year":"2016","journal-title":"J Infect Dis"},{"issue":"1","key":"10.1111\/jth.15050_bb0280","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41426-018-0063-8","article-title":"Blockade of the C5a\u2013C5aR axis alleviates lung damage in hDPP4\u2010transgenic mice infected with MERS\u2010CoV","volume":"7","author":"Jiang","year":"2018","journal-title":"Emerg Microbes Infect"},{"issue":"5","key":"10.1111\/jth.15050_bb0285","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01753-18","article-title":"Complement activation contributes to severe acute respiratory syndrome coronavirus pathogenesis","volume":"9","author":"Gralinski","year":"2018","journal-title":"MBio"},{"issue":"10","key":"10.1111\/jth.15050_bb0290","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1086\/429631","article-title":"Mannose\u2010binding lectin in severe acute respiratory syndrome coronavirus infection","volume":"191","author":"Ip","year":"2005","journal-title":"J Infect Dis"},{"key":"10.1111\/jth.15050_bb0295","article-title":"Highly pathogenic coronavirus N protein aggravates lung injury by MASP\u20102\u2010mediated complement over\u2010activation","author":"Gao","year":"2020","journal-title":"medRxiv"},{"issue":"6","key":"10.1111\/jth.15050_bb0300","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1128\/JCM.42.6.2629-2635.2004","article-title":"Sensitive and specific monoclonal antibody\u2010based capture enzyme immunoassay for detection of nucleocapsid antigen in sera from patients with severe acute respiratory syndrome","volume":"42","author":"Che","year":"2004","journal-title":"J Clin Microbiol"},{"issue":"11","key":"10.1111\/jth.15050_bb0305","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.3201\/eid1011.040516","article-title":"Nucleocapsid protein as early diagnostic marker for SARS","volume":"10","author":"Che","year":"2004","journal-title":"Emerg Infect Dis"},{"key":"10.1111\/jth.15050_bb0310","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2020.04.007","article-title":"Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID\u201019 infection: a report of five cases","volume":"220","author":"Magro","year":"2020","journal-title":"Transl Res"},{"key":"10.1111\/jth.15050_bb0315","article-title":"Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection","author":"Diao","year":"2020","journal-title":"medRxiv"},{"issue":"6501","key":"10.1111\/jth.15050_bb0320","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1126\/science.abb9983","article-title":"Site\u2010specific glycan analysis of the SARS\u2010CoV\u20102 spike","volume":"369","author":"Watanabe","year":"2020","journal-title":"Science"},{"issue":"10234","key":"10.1111\/jth.15050_bb0325","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0140-6736(20)30937-5","article-title":"Endothelial cell infection and endotheliitis in COVID\u201019","volume":"395","author":"Varga","year":"2020","journal-title":"Lancet"},{"issue":"1","key":"10.1111\/jth.15050_bb0330","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3904\/kjim.2019.388","article-title":"Consensus regarding diagnosis and management of atypical hemolytic uremic syndrome","volume":"35","author":"Lee","year":"2020","journal-title":"Korean J Intern Med"},{"issue":"6","key":"10.1111\/jth.15050_bb0335","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/imj.13804","article-title":"Consensus opinion on diagnosis and management of thrombotic microangiopathy in Australia and New Zealand","volume":"48","author":"Fox","year":"2018","journal-title":"Intern Med J"},{"issue":"6","key":"10.1111\/jth.15050_bb0340","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41577-020-0320-7","article-title":"Complement as a target in COVID\u201019?","volume":"20","author":"Risitano","year":"2020","journal-title":"Nat Rev Immunol"},{"issue":"9","key":"10.1111\/jth.15050_bb0345","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1182\/blood-2018-06-856930","article-title":"Inhibition of complement C1s improves severe hemolytic anemia in cold agglutinin disease: a first\u2010in\u2010human trial","volume":"133","author":"Jager","year":"2019","journal-title":"Blood"},{"issue":"2","key":"10.1111\/jth.15050_bb0350","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s12016-018-8684-1","article-title":"Update on the use of C1\u2010esterase inhibitor replacement therapy in the acute and prophylactic treatment of hereditary angioedema","volume":"56","author":"Henry Li","year":"2019","journal-title":"Clin Rev Allergy Immunol"},{"issue":"23","key":"10.1111\/jth.15050_bb0355","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1182\/blood.2020006000","article-title":"COVID\u201019 and its implications for thrombosis and anticoagulation","volume":"135","author":"Connors","year":"2020","journal-title":"Blood"},{"issue":"5","key":"10.1111\/jth.15050_bb0360","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/rth2.12406","article-title":"Antiviral anticoagulation","volume":"4","author":"Pryzdial","year":"2020","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1111\/jth.15050_bb0365","article-title":"Genotype and phenotype of COVID\u201019: their roles in pathogenesis","author":"Mousavizadeh","year":"2020","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1111\/jth.15050_bb0370","article-title":"Erythrocytes reveal complement activation in patients with COVID\u201019","author":"Lam","year":"2020","journal-title":"medRxiv"},{"key":"10.1111\/jth.15050_bb0375","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ebiom.2016.02.011","article-title":"complement activation in arterial and venous thrombosis is mediated by plasmin","volume":"5","author":"Foley","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1111\/jth.15050_bb0380","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3389\/fimmu.2017.00571","article-title":"Family proteins in complement evasion of microorganisms","volume":"8","author":"Jozsi","year":"2017","journal-title":"Front Immunol"},{"key":"10.1111\/jth.15050_bb0385","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.molimm.2017.05.012","article-title":"Intracellular complement \u2010 the complosome \u2010 in immune cell regulation","volume":"89","author":"Arbore","year":"2017","journal-title":"Mol Immunol"},{"issue":"6201","key":"10.1111\/jth.15050_bb0390","doi-asserted-by":"crossref","first-page":"1256070","DOI":"10.1126\/science.1256070","article-title":"Intracellular sensing of complement C3 activates cell autonomous immunity","volume":"345","author":"Tam","year":"2014","journal-title":"Science"},{"key":"10.1111\/jth.15050_bb0395","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.3389\/fimmu.2020.01206","article-title":"Could SARS\u2010CoV\u20102\u2010induced hyperinflammation magnify the severity of coronavirus disease (CoViD\u201019) leading to acute respiratory distress syndrome?","volume":"11","author":"Girija","year":"2020","journal-title":"Front Immunol"},{"issue":"6","key":"10.1111\/jth.15050_bb0400","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.chom.2020.05.009","article-title":"The innate immune system: fighting on the front lines or fanning the flames of COVID\u201019?","volume":"27","author":"McKechnie","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1111\/jth.15050_bb0405","doi-asserted-by":"crossref","first-page":"32188","DOI":"10.1038\/srep32188","article-title":"Effects of IL\u20101beta, IL\u20106 and IL\u20108 on erythrocytes, platelets and clot viscoelasticity","volume":"6","author":"Bester","year":"2016","journal-title":"Sci Rep"},{"issue":"5","key":"10.1111\/jth.15050_bb0410","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/jth.14759","article-title":"Cytokine and chemokine regulation of venous thromboembolism","volume":"18","author":"Najem","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.15050_bb0415","doi-asserted-by":"crossref","DOI":"10.1001\/jama.2020.12839","article-title":"Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID\u201019): a review","author":"Wiersinga","year":"2020","journal-title":"JAMA"},{"issue":"7","key":"10.1111\/jth.15050_bb0420","first-page":"E69","article-title":"Multi\u2010system inflammatory syndrome in children (MIS\u2010C) following SARS\u2010CoV\u20102 infection. review of clinical presentation, hypothetical pathogenesis, and proposed management","volume":"7","author":"Nakra","year":"2020","journal-title":"Children (Basel)"},{"issue":"4","key":"10.1111\/jth.15050_bb0425","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1056\/NEJMoa2021680","article-title":"Multisystem inflammatory syndrome in U.S. children and adolescents","volume":"383","author":"Feldstein","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1111\/jth.15050_bb0430","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3389\/fped.2020.00206","article-title":"COVID\u201019 infection and circulating ACE2 levels: protective role in women and children","volume":"8","author":"Ciaglia","year":"2020","journal-title":"Front Pediatr"},{"issue":"23","key":"10.1111\/jth.15050_bb0435","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1001\/jama.2020.8707","article-title":"Nasal gene expression of angiotensin\u2010converting enzyme 2 in children and adults","volume":"323","author":"Bunyavanich","year":"2020","journal-title":"JAMA"},{"issue":"4","key":"10.1111\/jth.15050_bb0440","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00749-2020","article-title":"Will children reveal their secret? The coronavirus dilemma","volume":"55","author":"Cristiani","year":"2020","journal-title":"Eur Respir J"},{"key":"10.1111\/jth.15050_bb0445","article-title":"Identification of immune complement function as a determinant of adverse SARS\u2010CoV\u20102 infection outcome","author":"Ramlall","year":"2020","journal-title":"medRxiv"},{"issue":"7726","key":"10.1111\/jth.15050_bb0450","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK Biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"key":"10.1111\/jth.15050_bb0455","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7532507","article-title":"Complement system and age\u2010related macular degeneration: implications of gene\u2010environment interaction for preventive and personalized medicine","volume":"2018","author":"Maugeri","year":"2018","journal-title":"Biomed Res Int"},{"issue":"2","key":"10.1111\/jth.15050_bb0460","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.kint.2020.05.013","article-title":"The case of complement activation in COVID\u201019 multiorgan impact","volume":"98","author":"Noris","year":"2020","journal-title":"Kidney Int"},{"issue":"3","key":"10.1111\/jth.15050_bb0465","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-3083.2006.01729.x","article-title":"Clinical aspects and molecular basis of primary deficiencies of complement component C3 and its regulatory proteins factor I and factor H","volume":"63","author":"Reis","year":"2006","journal-title":"Scand J Immunol"},{"key":"10.1111\/jth.15050_bb0470","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.clim.2018.09.004","article-title":"Safety profile after prolonged C3 inhibition","volume":"197","author":"Reis","year":"2018","journal-title":"Clin Immunol"},{"key":"10.1111\/jth.15050_bb0475","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2020.108450","article-title":"The first case of COVID\u201019 treated with the complement C3 inhibitor AMY\u2010101","volume":"215","author":"Mastaglio","year":"2020","journal-title":"Clin Immunol"},{"key":"10.1111\/jth.15050_bb0480","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.3389\/fimmu.2018.01851","article-title":"Be on target: strategies of targeting alternative and lectin pathway components in complement\u2010mediated diseases","volume":"9","author":"Dobo","year":"2018","journal-title":"Front Immunol"},{"issue":"2","key":"10.1111\/jth.15050_bb0485","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s12016-016-8555-6","article-title":"Complement, kinins, and hereditary angioedema: mechanisms of plasma instability when C1 inhibitor is absent","volume":"51","author":"Kaplan","year":"2016","journal-title":"Clin Rev Allergy Immunol"},{"issue":"7","key":"10.1111\/jth.15050_bb0490","first-page":"4040","article-title":"Eculizumab treatment in patients with COVID\u201019: preliminary results from real life ASL Napoli 2 Nord experience","volume":"24","author":"Diurno","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1","key":"10.1111\/jth.15050_bb0495","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/bjh.12347","article-title":"Long\u2010term safety and efficacy of sustained eculizumab treatment in patients with paroxysmal nocturnal haemoglobinuria","volume":"162","author":"Hillmen","year":"2013","journal-title":"Br J Haematol"},{"issue":"1","key":"10.1111\/jth.15050_bb0500","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jaci.2020.05.006","article-title":"Complement activation in patients with COVID\u201019: A novel therapeutic target","volume":"146","author":"Cugno","year":"2020","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.15050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.15050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jth.15050","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153878362203728X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153878362203728X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.15050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:26:34Z","timestamp":1761535594000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S153878362203728X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":99,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S153878362203728X"],"URL":"https:\/\/doi.org\/10.1111\/jth.15050","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is the COVID\u201019 thrombotic catastrophe complement\u2010connected?","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/jth.15050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}