{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:32:45Z","timestamp":1761535965083,"version":"build-2065373602"},"reference-count":16,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"vor","delay-in-days":704,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000093","name":"Center for Information Technology","doi-asserted-by":"publisher","award":["HL081588"],"award-info":[{"award-number":["HL081588"]}],"id":[{"id":"10.13039\/100000093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000989","name":"Australian Academy of the Humanities","doi-asserted-by":"publisher","award":["ILP\u2010POR\u20102017\u2010008"],"award-info":[{"award-number":["ILP\u2010POR\u20102017\u2010008"]}],"id":[{"id":"10.13039\/501100000989","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["11\/PI\/1066"],"award-info":[{"award-number":["11\/PI\/1066"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1111\/jth.15123","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T22:41:39Z","timestamp":1610059299000},"page":"55-57","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Correcting dominant\u2010negative von Willebrand disease"],"prefix":"10.1016","volume":"19","author":[{"given":"Ellie","family":"Karampini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0309-3313","authenticated-orcid":false,"given":"James S.","family":"O\u2019Donnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"13","key":"10.1111\/jth.15123_bb0010","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1182\/blood-2014-06-528406","article-title":"von Willebrand factor biosynthesis, secretion, and clearance: connecting the far ends","volume":"125","author":"Lenting","year":"2015","journal-title":"Blood"},{"issue":"21","key":"10.1111\/jth.15123_bb0015","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1056\/NEJMra1601561","article-title":"Von Willebrand's Disease","volume":"375","author":"Leebeek","year":"2016","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1111\/jth.15123_bb0020","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/bjh.13064","article-title":"The diagnosis and management of von Willebrand disease: a United Kingdom Haemophilia Centre Doctors Organization guideline approved by the British Committee for Standards in Haematology","volume":"167","author":"Laffan","year":"2014","journal-title":"Br J Haematol"},{"key":"10.1111\/jth.15123_bb0025","doi-asserted-by":"crossref","DOI":"10.1111\/bjh.16681","article-title":"New developments in von Willebrand disease","author":"Fogarty","year":"2020","journal-title":"Br J Haematol"},{"issue":"3","key":"10.1111\/jth.15123_bb0030","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.blre.2010.03.003","article-title":"The genetic basis of von Willebrand disease","volume":"24","author":"Goodeve","year":"2010","journal-title":"Blood Rev"},{"key":"10.1111\/jth.15123_bb0035","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.thromres.2017.09.025","article-title":"Von Willebrand disease mutation spectrum and associated mutation mechanisms","volume":"159","author":"de Jong","year":"2017","journal-title":"Thromb Res"},{"issue":"24","key":"10.1111\/jth.15123_bb0040","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.1182\/blood-2010-02-268920","article-title":"The dominant\u2010negative von Willebrand factor gene deletion p. P1127_C1948delinsR: molecular mechanism and modulation","volume":"116","author":"Casari","year":"2010","journal-title":"Blood"},{"issue":"7","key":"10.1111\/jth.15123_bb0045","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1111\/jth.14140","article-title":"Correction of a dominant\u2010negative von Willebrand factor multimerization defect by small interfering RNA\u2010mediated allele\u2010specific inhibition of mutant von Willebrand factor","volume":"16","author":"de Jong","year":"2018","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.15123_bb0050","article-title":"Ex vivo Improvement of a von Willebrand Disease Type 2A Phenotype Using an Allele\u2010Specific Small\u2010Interfering RNA","author":"de Jong","year":"2020","journal-title":"Thromb Haemost"},{"issue":"6","key":"10.1111\/jth.15123_bb0055","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1160\/TH06-08-0460","article-title":"Differential effects of the loss of intrachain\u2010 versus interchain\u2010disulfide bonds in the cystine\u2010knot domain of von Willebrand factor on the clinical phenotype of von Willebrand disease","volume":"96","author":"Tjernberg","year":"2006","journal-title":"Thromb Haemost"},{"issue":"8","key":"10.1111\/jth.15123_bb0060","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/iub.487","article-title":"Targeted siRNA delivery to diseased microvascular endothelial cells: cellular and molecular concepts","volume":"63","author":"Kowalski","year":"2011","journal-title":"IUBMB Life"},{"issue":"1","key":"10.1111\/jth.15123_bb0065","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s12967-017-1270-0","article-title":"RNAi therapy to the wall of arteries and veins: anatomical, physiologic, and pharmacological considerations","volume":"15","author":"Nabzdyk","year":"2017","journal-title":"J Transl Med"},{"issue":"14","key":"10.1111\/jth.15123_bb0070","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1182\/blood-2018-09-874636","article-title":"Increased galactose expression and enhanced clearance in patients with low von Willebrand factor","volume":"133","author":"Aguila","year":"2019","journal-title":"Blood"},{"issue":"20","key":"10.1111\/jth.15123_bb0075","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1182\/blood-2015-10-673681","article-title":"Clinical and laboratory variability in a cohort of patients diagnosed with type 1 VWD in the United States","volume":"127","author":"Flood","year":"2016","journal-title":"Blood"},{"issue":"1","key":"10.1111\/jth.15123_bb0080","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1182\/asheducation-2016.1.683","article-title":"New treatment approaches to von Willebrand disease","volume":"2016","author":"Lavin","year":"2016","journal-title":"Hematology Am Soc Hematol Educ Program"},{"issue":"8","key":"10.1111\/jth.15123_bb0085","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1182\/blood-2018-10-844936","article-title":"How I treat low von Willebrand factor levels","volume":"133","author":"Lavin","year":"2019","journal-title":"Blood"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.15123","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jth.15123","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622004342?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622004342?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.15123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:29:19Z","timestamp":1761535759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622004342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S1538783622004342"],"URL":"https:\/\/doi.org\/10.1111\/jth.15123","relation":{},"ISSN":["1538-7836"],"issn-type":[{"type":"print","value":"1538-7836"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Correcting dominant\u2010negative von Willebrand disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/jth.15123","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}