{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:37:16Z","timestamp":1761536236721,"version":"build-2065373602"},"reference-count":54,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":640,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL095868","R01HL130274","R01HL144113"],"award-info":[{"award-number":["R01HL095868","R01HL130274","R01HL144113"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005440","name":"Center for Scientific Review","doi-asserted-by":"publisher","award":["P51 OD011092"],"award-info":[{"award-number":["P51 OD011092"]}],"id":[{"id":"10.13039\/100005440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1111\/jth.15180","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T07:25:32Z","timestamp":1605684332000},"page":"502-512","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Quantification of microbubble\u2010induced sonothrombolysis in an ex vivo non\u2010human primate model"],"prefix":"10.1016","volume":"19","author":[{"given":"Monica T.","family":"Hinds","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azzdine Y.","family":"Ammi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0124-3920","authenticated-orcid":false,"given":"Sanjiv","family":"Kaul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1111\/jth.15180_bb0010","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1016\/0735-1097(94)90157-0","article-title":"High intensity, low frequency catheter\u2010delivered ultrasound dissolution of occlusive coronary artery thrombi: an in vitro and in vivo study","volume":"24","author":"Steffen","year":"1994","journal-title":"J Am Coll Cardiol"},{"key":"10.1111\/jth.15180_bb0015","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1161\/CIRCULATIONAHA.108.825067","article-title":"Diagnostic ultrasound combined with glycoprotein IIb\/IIIa\u2013targeted microbubbles improves microvascular recovery after acute coronary thrombotic occlusions","volume":"119","author":"Xie","year":"2009","journal-title":"Circulation"},{"key":"10.1111\/jth.15180_bb0020","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1136\/heartjnl-2015-307625","article-title":"Utilization of modified diagnostic ultrasound and microbubbles to reduce myocardial infarct size","volume":"101","author":"Wu","year":"2015","journal-title":"Heart"},{"key":"10.1111\/jth.15180_bb0025","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/S0002-9149(03)00666-0","article-title":"Transcutaneous ultrasound\u2010facilitated coronary thrombolysis during acute myocardial infarction","volume":"92","author":"Cohen","year":"2003","journal-title":"Am J Cardiol"},{"key":"10.1111\/jth.15180_bb0030","first-page":"354","article-title":"Adjunctive transcutaneous ultrasound with thrombolysis: results of the PLUS (Perfusion in ThromboLytic and UltraSound) Trial","volume":"3","author":"Hudson","year":"2010","journal-title":"JACC: Cardiovasc Interven"},{"key":"10.1111\/jth.15180_bb0035","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1016\/j.jacc.2019.03.006","article-title":"Sonothrombolysis in ST\u2010segment elevation myocardial infarction treated with primary percutaneous coronary intervention","volume":"73","author":"Mathias","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1111\/jth.15180_bb0040","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.ultrasmedbio.2012.05.020","article-title":"Effect of acoustic conditions on microbubble\u2010mediated microvascular sonothrombolysis","volume":"38","author":"Leeman","year":"2012","journal-title":"Ultrasound Med Biol"},{"key":"10.1111\/jth.15180_bb0045","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.ultrasmedbio.2008.01.016","article-title":"Ultrasound\u2010enhanced thrombolysis using definity\u00ae as a cavitation nucleation agent","volume":"34","author":"Datta","year":"2008","journal-title":"Ultrasound Med Biol"},{"key":"10.1111\/jth.15180_bb0050","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.ultrasmedbio.2006.11.022","article-title":"Cavitational mechanisms in ultrasound\u2010accelerated fibrinolysis","volume":"33","author":"Prokop","year":"2007","journal-title":"Ultrasound Med Biol"},{"key":"10.1111\/jth.15180_bb0055","first-page":"330","article-title":"Investigation of effectiveness of microbubble stable cavitation in thrombolysis","author":"Shi","year":"2010","journal-title":"IEEE Ultrasonics Symposium"},{"key":"10.1111\/jth.15180_bb0060","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1160\/TH14-03-0286","article-title":"Efficacy and spatial distribution of ultrasound\u2010mediated clot lysis in the absence of thrombolytics","volume":"113","author":"Ammi","year":"2015","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.15180_bb0065","doi-asserted-by":"crossref","first-page":"365S","DOI":"10.1378\/chest.102.4_Supplement.364S","article-title":"Hemorrhagic complications of thrombolytic therapy in the treatment of myocardial infarction and venous thromboembolism","volume":"102","author":"Levine","year":"1992","journal-title":"Chest"},{"key":"10.1111\/jth.15180_bb0070","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1161\/01.STR.31.8.1802","article-title":"Intracranial hemorrhage associated with thrombolytic therapy for elderly patients with acute myocardial infarction","volume":"31","author":"Brass","year":"2000","journal-title":"Stroke"},{"key":"10.1111\/jth.15180_bb0075","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1161\/01.CIR.99.21.2720","article-title":"Abciximab facilitates the rate and extent of thrombolysis: results of the thrombolysis in myocardial infarction (TIMI) 14 trial. The TIMI 14 Investigators","volume":"99","author":"Antman","year":"1999","journal-title":"Circulation"},{"issue":"Suppl 6","key":"10.1111\/jth.15180_bb0080","first-page":"41","article-title":"Experimental arterial thrombosis in nonhuman primates","volume":"83","author":"Harker","year":"1991","journal-title":"Circulation"},{"key":"10.1111\/jth.15180_bb0085","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1152\/jappl.1966.21.6.1713","article-title":"Similarities between baboon and human blood clotting","volume":"21","author":"Hampton","year":"1966","journal-title":"J Appl Physiol"},{"key":"10.1111\/jth.15180_bb0090","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1159\/000460376","article-title":"Blood\u2010clotting mechanisms of nonhuman primates. Choice of the baboon model to simulate man","volume":"1","author":"Todd","year":"1972","journal-title":"J Med Primatol"},{"key":"10.1111\/jth.15180_bb0095","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1161\/ATVBAHA.118.312328","article-title":"Contact activation inhibitor and factor XI antibody, AB023, produces safe, dose\u2010dependent anticoagulation in a phase 1 first\u2010in\u2010human trial","volume":"39","author":"Lorentz","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/jth.15180_bb0100","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1172\/JCI116795","article-title":"Antithrombotic effects of thrombin\u2010induced activation of endogenous protein C in primates","volume":"92","author":"Hanson","year":"1993","journal-title":"J Clin Invest"},{"issue":"Pt 2","key":"10.1111\/jth.15180_bb0105","first-page":"773","article-title":"Pharmacologic modification of acute vascular graft thrombosis","author":"Hanson","year":"1982","journal-title":"Scan Electron Microsc"},{"key":"10.1111\/jth.15180_bb0110","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1161\/01.CIR.98.22.2461","article-title":"Clopidogrel inhibition of stent, graft, and vascular thrombogenesis with antithrombotic enhancement by aspirin in nonhuman primates","volume":"98","author":"Harker","year":"1998","journal-title":"Circulation"},{"key":"10.1111\/jth.15180_bb0115","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1182\/blood.V73.3.639.639","article-title":"Inhibition of platelet\u2010dependent thrombus formation by human activated protein C in a primate model","volume":"73","author":"Gruber","year":"1989","journal-title":"Blood"},{"key":"10.1111\/jth.15180_bb0120","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1161\/01.CIR.94.6.1412","article-title":"Enhanced thrombolytic and antithrombotic potency of a fibrin\u2010targeted plasminogen activator in baboons","volume":"94","author":"Runge","year":"1996","journal-title":"Circulation"},{"key":"10.1111\/jth.15180_bb0125","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1182\/blood.2019002771","article-title":"The protein C activator AB002 rapidly interrupts thrombus development in baboons","volume":"135","author":"Tucker","year":"2020","journal-title":"Blood"},{"key":"10.1111\/jth.15180_bb0130","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1161\/ATVBAHA.113.301282","article-title":"Antithrombotic effect of antisense factor XI oligonucleotide treatment in primates","volume":"33","author":"Crosby","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/jth.15180_bb0135","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1161\/01.ATV.5.6.595","article-title":"Platelet interactions with Dacron vascular grafts. A model of acute thrombosis in baboons","volume":"5","author":"Hanson","year":"1985","journal-title":"Arteriosclerosis"},{"key":"10.1111\/jth.15180_bb0140","first-page":"289","article-title":"In vivo evaluation of artificial surfaces with a nonhuman primate model of arterial thrombosis","volume":"95","author":"Hanson","year":"1980","journal-title":"J Lab Clin Med"},{"key":"10.1111\/jth.15180_bb0145","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1161\/01.ATV.10.3.367","article-title":"Inhibition of thrombus formation in vivo by novel antiplatelet agent","volume":"10","author":"Marzec","year":"1990","journal-title":"Arteriosclerosis"},{"key":"10.1111\/jth.15180_bb0150","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/0002-8703(90)90088-F","article-title":"Ultrasonic clot disruption: an in vitro study","volume":"120","author":"Hong","year":"1990","journal-title":"Am Heart J"},{"key":"10.1111\/jth.15180_bb0155","first-page":"173","article-title":"Effects of ultrasound energy on thrombi in vitro","volume":"28","author":"Philippe","year":"1993","journal-title":"Cath Cardiovasc Diag"},{"key":"10.1111\/jth.15180_bb0160","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1172\/JCI116088","article-title":"Enhancement fibrinolysis in vitro by ultrasound","volume":"90","author":"Francis","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1111\/jth.15180_bb0165","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1182\/blood.V81.10.2636.2636","article-title":"Characterization of ultrasound\u2010potentiated fibrinolysis in vitro","volume":"81","author":"Blinc","year":"1993","journal-title":"Blood"},{"key":"10.1111\/jth.15180_bb0170","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/0735-1097(93)90331-T","article-title":"Ultrasound enhancement of thrombolysis and reperfusion in vitro","volume":"21","author":"Harpaz","year":"1993","journal-title":"J Am Coll Cardiol"},{"key":"10.1111\/jth.15180_bb0175","first-page":"697s","article-title":"Thrombolysis by ultrasound","volume":"51","author":"Tr\u00fcbestein","year":"1976","journal-title":"Clin Sci Mol Med"},{"key":"10.1111\/jth.15180_bb0180","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/0735-1097(90)90651-5","article-title":"Experimental ultrasonic angioplasty: disruption of atherosclerotic plaques and thrombi in vitro and arterial recanalization in vivo","volume":"15","author":"Rosenschein","year":"1990","journal-title":"J Am Coll Cardiol"},{"key":"10.1111\/jth.15180_bb0185","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1161\/01.CIR.84.4.1680","article-title":"Dissolution of peripheral arterial thrombi by ultrasound","volume":"84","author":"Ariani","year":"1991","journal-title":"Circulation"},{"key":"10.1111\/jth.15180_bb0190","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1161\/01.CIR.86.4.1257","article-title":"Effect of ultrasound on tissue\u2010type plasminogen activator\u2010induced thrombolysis","volume":"86","author":"Lauer","year":"1992","journal-title":"Circulation"},{"key":"10.1111\/jth.15180_bb0195","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1177\/096721099700500211","article-title":"Ultrasound enhancement of rabbit femoral artery thrombolysis","volume":"5","author":"Riggs","year":"1997","journal-title":"Cardiovasc Surg"},{"key":"10.1111\/jth.15180_bb0200","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1161\/01.CIR.94.4.775","article-title":"Transcutaneous ultrasound augments lysis of arterial thrombi in vivo","volume":"94","author":"Luo","year":"1996","journal-title":"Circulation"},{"key":"10.1111\/jth.15180_bb0205","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/S0002-8703(96)90006-X","article-title":"Thrombolytic enhancement with perfluorocarbon\u2010exposed sonicated dextrose albumin microbubbles","volume":"132","author":"Porter","year":"1996","journal-title":"Am Heart J"},{"key":"10.1111\/jth.15180_bb0210","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1161\/01.CIR.97.2.130","article-title":"Noninvasive in vivo clot dissolution without a thrombolytic drug: Recanalization of thrombosed iliofemoral arteries by transcutaneous ultrasound combined with intravenous infusion of microbubbles","volume":"97","author":"Birnbaum","year":"1998","journal-title":"Circulation"},{"key":"10.1111\/jth.15180_bb0215","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0735-1097(97)00182-4","article-title":"Dissolution of thrombotic arterial occlusion by high intensity, low frequency ultrasound and dodecafluoropentane emulsion: an in vitro and in vivo study","volume":"30","author":"Nishioka","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"10.1111\/jth.15180_bb0220","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.echo.2019.09.011","article-title":"Therapeutic ultrasound improves myocardial blood flow and reduces infarct size in a canine model of coronary microthromboembolism","volume":"33","author":"Yadava","year":"2020","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1111\/jth.15180_bb0225","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.echo.2019.05.012","article-title":"Therapeutic ultrasound increases myocardial blood flow in ischemic myocardium and cardiac endothelial cells: results of in\u2010vivo and in\u2010vitro experiments","volume":"32","author":"Mott","year":"2019","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1111\/jth.15180_bb0230","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1055\/s-0037-1613315","article-title":"Ultrasound improves tissue perfusion in ischemic tissue through a nitric oxide dependent mechanism","volume":"88","author":"Suchkova","year":"2002","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.15180_bb0235","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.jacc.2004.06.062","article-title":"Ultrasound energy improves myocardial perfusion in the presence of coronary occlusion","volume":"44","author":"Siegel","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1111\/jth.15180_bb0240","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jacc.2006.03.046","article-title":"Noninvasive low\u2010frequency ultrasound energy causes vasodilation in humans","volume":"48","author":"Lida","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1111\/jth.15180_bb0245","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1161\/01.CIR.101.13.1619","article-title":"Thrombi in acute coronary syndromes. Revisited and revised","volume":"101","author":"Rentrop","year":"2000","journal-title":"Circulation"},{"key":"10.1111\/jth.15180_bb0250","first-page":"1194","article-title":"Molecular imaging identifies regions with microthromboemboli during primary angioplasty in acute coronary thrombosis","volume":"45","author":"Sakuma","year":"2004","journal-title":"J Nucl Med"},{"key":"10.1111\/jth.15180_bb0255","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1067\/mje.2003.44","article-title":"Further insights into the \u2018No\u2010reflow\u2019 phenomenon after primary angioplasty in acute myocardial infarction: the role of microthromboemboli","volume":"16","author":"Sakuma","year":"2003","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1111\/jth.15180_bb0260","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.cardiores.2005.01.016","article-title":"Simultaneous \u03b1v\u03b23 and IIb\/IIIa inhibition causes a marked reduction in infarct size following reperfusion in a canine model of acute coronary thrombosis: utility of in\u2010vivo molecular imaging with myocardial contrast echocardiography","volume":"66","author":"Sakuma","year":"2005","journal-title":"Cardiovasc Res"},{"key":"10.1111\/jth.15180_bb0265","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1161\/01.CIR.89.1.339","article-title":"Does external ultrasound accelerate thrombolysis? Results from a rabbit model","volume":"89","author":"Kornowski","year":"1994","journal-title":"Circulation"},{"key":"10.1111\/jth.15180_bb0270","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0301-5629(95)00014-I","article-title":"Pro\u2010 and antifibrinolytic effects of ultrasound on streptokinase\u2010induced thrombolysis","volume":"21","author":"Nilsson","year":"1995","journal-title":"Ultrasound Med Biol"},{"key":"10.1111\/jth.15180_bb0275","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0741-5214(99)70282-X","article-title":"Use of high\u2010intensity focused ultrasound to control bleeding","volume":"29","author":"Vaezy","year":"1999","journal-title":"J Vasc Surg"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.15180","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jth.15180","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622006638?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622006638?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.15180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:32:53Z","timestamp":1761535973000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622006638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S1538783622006638"],"URL":"https:\/\/doi.org\/10.1111\/jth.15180","relation":{},"ISSN":["1538-7836"],"issn-type":[{"type":"print","value":"1538-7836"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantification of microbubble\u2010induced sonothrombolysis in an ex vivo non\u2010human primate model","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/jth.15180","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}