{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T06:19:52Z","timestamp":1777011592628,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"vor","delay-in-days":582,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31620103909"],"award-info":[{"award-number":["31620103909"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973995"],"award-info":[{"award-number":["81973995"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1111\/jth.15261","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T09:12:09Z","timestamp":1612602729000},"page":"1038-1048","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Clinical characteristics and risk factors for symptomatic venous thromboembolism in hospitalized COVID\u201019 patients: A multicenter retrospective study"],"prefix":"10.1016","volume":"19","author":[{"given":"Jun\u2010Ying","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di\u2010Le","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Wei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Yuan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nian","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Xiu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Jun","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben\u2010De","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Zhu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3253-0220","authenticated-orcid":false,"given":"Liang V.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory Y.H.","family":"Lip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9610","key":"10.1111\/jth.15261_bb0010","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0140-6736(08)60202-0","article-title":"Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross\u2010sectional study","volume":"371","author":"Cohen","year":"2008","journal-title":"Lancet"},{"issue":"6","key":"10.1111\/jth.15261_bb0015","doi-asserted-by":"crossref","first-page":"e438","DOI":"10.1016\/S2352-3026(20)30145-9","article-title":"Coagulation abnormalities and thrombosis in patients with COVID\u201019","volume":"7","author":"Levi","year":"2020","journal-title":"Lancet Haematol"},{"issue":"06","key":"10.1111\/jth.15261_bb0020","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1055\/s-0040-1710019","article-title":"Prevention and treatment of venous thromboembolism associated with coronavirus disease 2019 infection: a consensus statement before guidelines","volume":"120","author":"Zhai","year":"2020","journal-title":"Thromb Haemost"},{"issue":"3","key":"10.1111\/jth.15261_bb0025","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1056\/NEJMc2013656","article-title":"Lupus anticoagulant and abnormal coagulation tests in patients with Covid\u201019","volume":"383","author":"Bowles","year":"2020","journal-title":"N Engl J Med"},{"issue":"19","key":"10.1111\/jth.15261_bb0030","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1093\/eurheartj\/ehaa254","article-title":"Acute pulmonary embolism and COVID\u201019 pneumonia: a random association?","volume":"41","author":"Danzi","year":"2020","journal-title":"Eur Heart J"},{"issue":"5","key":"10.1111\/jth.15261_bb0035","doi-asserted-by":"crossref","first-page":"350","DOI":"10.7326\/M20-2566","article-title":"Pulmonary arterial thrombosis in COVID\u201019 with fatal outcome","volume":"173","author":"Lax","year":"2020","journal-title":"Ann Intern Med"},{"issue":"23","key":"10.1111\/jth.15261_bb0040","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1016\/j.jacc.2020.04.031","article-title":"COVID\u201019 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow\u2010up","volume":"75","author":"Bikdeli","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1111\/jth.15261_bb0045","article-title":"Catastrophic intracranial hemorrhage in two critically ill patients with COVID\u201019","author":"Carroll","year":"2020","journal-title":"Neurocrit Care"},{"issue":"10234","key":"10.1111\/jth.15261_bb0050","doi-asserted-by":"crossref","first-page":"e75","DOI":"10.1016\/S0140-6736(20)30926-0","article-title":"Hospital\u2010based use of thromboprophylaxis in patients with COVID\u201019","volume":"395","author":"Spyropoulos","year":"2020","journal-title":"Lancet"},{"issue":"2","key":"10.1111\/jth.15261_bb0055","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000498990","article-title":"Association of intraoperative hypotension with acute kidney injury after noncardiac surgery in patients younger than 60 years old","volume":"44","author":"Tang","year":"2019","journal-title":"Kidney Blood Press Res"},{"issue":"10229","key":"10.1111\/jth.15261_bb0060","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID\u201019 in Wuhan, China: a retrospective cohort study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet"},{"issue":"11","key":"10.1111\/jth.15261_bb0065","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/jama.2020.1585","article-title":"Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus\u2010infected pneumonia in Wuhan, China","volume":"323","author":"Wang","year":"2020","journal-title":"JAMA"},{"issue":"4","key":"10.1111\/jth.15261_bb0070","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1160\/TH16-08-0631","article-title":"Risk assessment models for venous thromboembolism in acutely ill medical patients. A systematic review","volume":"117","author":"Stuck","year":"2017","journal-title":"Thrombosis Haemostasis"},{"issue":"6","key":"10.1111\/jth.15261_bb0075","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1111\/jth.14796","article-title":"Validation of risk assessment models predicting venous thromboembolism in acutely ill medical inpatients: a cohort study","volume":"18","author":"Moumneh","year":"2020","journal-title":"J Thromb Haemost"},{"issue":"3","key":"10.1111\/jth.15261_bb0080","doi-asserted-by":"crossref","first-page":"E189","DOI":"10.1148\/radiol.2020201561","article-title":"Acute pulmonary embolism in COVID\u201019 patients on CT angiography and relationship to D\u2010Dimer levels","volume":"296","author":"Leonard\u2010Lorant","year":"2020","journal-title":"Radiology"},{"key":"10.1111\/jth.15261_bb0085","article-title":"Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID\u201019: An updated analysis","author":"Klok","year":"2020","journal-title":"Thromb Res"},{"key":"10.1111\/jth.15261_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2020.106023","article-title":"D\u2010dimer in patients infected with COVID\u201019 and suspected pulmonary embolism","volume":"169","author":"Garcia\u2010Olive","year":"2020","journal-title":"Respir Med"},{"issue":"2","key":"10.1111\/jth.15261_bb0095","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1161\/CIRCULATIONAHA.120.046702","article-title":"Deep vein thrombosis in hospitalized patients with coronavirus disease 2019 (COVID\u201019) in Wuhan, China: prevalence, risk factors, and outcome","volume":"142","author":"Zhang","year":"2020","journal-title":"Circulation"},{"issue":"2","key":"10.1111\/jth.15261_bb0100","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1161\/CIRCULATIONAHA.120.047407","article-title":"Extremely high incidence of lower extremity deep venous thrombosis in 48 patients with severe COVID\u201019 in Wuhan","volume":"142","author":"Ren","year":"2020","journal-title":"Circulation"},{"issue":"7","key":"10.1111\/jth.15261_bb0105","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1111\/jth.14869","article-title":"High incidence of venous thromboembolic events in anticoagulated severe COVID\u201019 patients","volume":"18","author":"Llitjos","year":"2020","journal-title":"J Thromb Haemost"},{"issue":"6","key":"10.1111\/jth.15261_bb0110","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s00134-020-06062-x","article-title":"High risk of thrombosis in patients with severe SARS\u2010CoV\u20102 infection: a multicenter prospective cohort study","volume":"16","author":"Helms","year":"2020","journal-title":"Intensive Care Med"},{"issue":"9","key":"10.1111\/jth.15261_bb0115","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1161\/ATVBAHA.120.314779","article-title":"Comparison of venous thromboembolism risks between COVID\u201019 pneumonia and community\u2010acquired pneumonia patients","volume":"40","author":"Mei","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/jth.15261_bb0120","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.thromres.2020.04.013","article-title":"Incidence of thrombotic complications in critically ill ICU patients with COVID\u201019","volume":"191","author":"Klok","year":"2020","journal-title":"Thromb Res"},{"issue":"8","key":"10.1111\/jth.15261_bb0125","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1111\/jth.14888","article-title":"Incidence of venous thromboembolism in hospitalized patients with COVID\u201019","volume":"18","author":"Middeldorp","year":"2020","journal-title":"J Thromb Haemost"},{"issue":"1","key":"10.1111\/jth.15261_bb0130","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01365-2020","article-title":"Pulmonary embolism in patients with Covid\u201019 pneumonia","volume":"56","author":"Bompard","year":"2020","journal-title":"Eur Respir J"},{"issue":"4","key":"10.1111\/jth.15261_bb0135","doi-asserted-by":"crossref","first-page":"e76","DOI":"10.7861\/clinmed.2020-0228","article-title":"Thrombotic risk in COVID\u201019: a case series and case\u2010control study","volume":"20","author":"Stoneham","year":"2020","journal-title":"Clin Med"},{"key":"10.1111\/jth.15261_bb0140","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.thromres.2020.04.024","article-title":"Venous and arterial thromboembolic complications in COVID\u201019 patients admitted to an academic hospital in Milan, Italy","volume":"191","author":"Lodigiani","year":"2020","journal-title":"Thromb Res"},{"key":"10.1111\/jth.15261_bb0145","article-title":"Incidence of VTE and bleeding among hospitalized patients with coronavirus disease 2019: a systematic review and meta\u2010analysis","author":"Jim\u00e9nez","year":"2020","journal-title":"Chest"},{"issue":"12","key":"10.1111\/jth.15261_bb0150","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1253\/circj.CJ-17-0445","article-title":"Asymptomatic lower extremity deep vein thrombosis\u2010clinical characteristics, management strategies, and long\u2010term outcomes","volume":"81","author":"Yamashita","year":"2017","journal-title":"Circ J"},{"issue":"3","key":"10.1111\/jth.15261_bb0155","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1538-7836.2007.02847.x","article-title":"Anticoagulant prophylaxis to prevent asymptomatic deep vein thrombosis in hospitalized medical patients: a systematic review and meta\u2010analysis","volume":"6","author":"Lloyd","year":"2008","journal-title":"J Thromb Haemost"},{"issue":"12","key":"10.1111\/jth.15261_bb0160","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1055\/s-0038-1675606","article-title":"Asymptomatic deep vein thrombosis is associated with an increased risk of death: insights from the APEX Trial","volume":"118","author":"Kalayci","year":"2018","journal-title":"Thromb Haemost"},{"issue":"1","key":"10.1111\/jth.15261_bb0165","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1160\/TH04-05-0323","article-title":"Mortality rates and risk factors for asymptomatic deep vein thrombosis in medical patients","volume":"93","author":"Vaitkus","year":"2005","journal-title":"Thromb Haemost"},{"issue":"2","key":"10.1111\/jth.15261_bb0170","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1024\/0301-1526.38.2.160","article-title":"Asymptomatic venous thrombosis in cancer patients\u2013a problem often overlooked. Results of a retrospective and prospective study","volume":"38","author":"Heidrich","year":"2009","journal-title":"Vasa"},{"issue":"5","key":"10.1111\/jth.15261_bb0175","doi-asserted-by":"crossref","first-page":"e362","DOI":"10.1016\/S2352-3026(20)30109-5","article-title":"Attention should be paid to venous thromboembolism prophylaxis in the management of COVID\u201019","volume":"7","author":"Wang","year":"2020","journal-title":"Lancet Haematol"},{"issue":"23","key":"10.1111\/jth.15261_bb0180","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1182\/blood.2020006000","article-title":"COVID\u201019 and its implications for thrombosis and anticoagulation","volume":"135","author":"Connors","year":"2020","journal-title":"Blood"},{"issue":"5","key":"10.1111\/jth.15261_bb0185","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/jth.14817","article-title":"Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy","volume":"18","author":"Tang","year":"2020","journal-title":"J Thromb Haemost"},{"issue":"3","key":"10.1111\/jth.15261_bb0190","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.chest.2020.05.559","article-title":"Prevention, diagnosis and treatment of venous thromboembolism in patients with COVID\u201019: CHEST Guideline and Expert Panel Report","volume":"158","author":"Moores","year":"2020","journal-title":"Chest"},{"issue":"4","key":"10.1111\/jth.15261_bb0195","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1182\/blood.2020006520","article-title":"COVID and coagulation: bleeding and thrombotic manifestations of SARS\u2010CoV2 infection","volume":"136","author":"Al\u2010Samkari","year":"2020","journal-title":"Blood"},{"issue":"8","key":"10.1111\/jth.15261_bb0200","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1111\/jth.14929","article-title":"Scientific and standardization committee communication: clinical guidance on the diagnosis, prevention and treatment of VTE in hospitalized patients with COVID\u201019","volume":"18","author":"Spyropoulos","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.15261_bb0205","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.thromres.2020.09.022","article-title":"D\u2010dimer cut\u2010off points and risk of venous thromboembolism in adult hospitalized patients with COVID\u201019","volume":"196","author":"Choi","year":"2020","journal-title":"Thromb Res"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.15261","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jth.15261","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153878362200736X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153878362200736X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.15261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:31:09Z","timestamp":1761535869000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S153878362200736X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S153878362200736X"],"URL":"https:\/\/doi.org\/10.1111\/jth.15261","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical characteristics and risk factors for symptomatic venous thromboembolism in hospitalized COVID\u201019 patients: A multicenter retrospective study","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/jth.15261","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}