{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:06:41Z","timestamp":1761541601856,"version":"build-2065373602"},"reference-count":47,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"vor","delay-in-days":521,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL007209","HL068835"],"award-info":[{"award-number":["HL007209","HL068835"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1111\/jth.15299","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T04:00:56Z","timestamp":1615953656000},"page":"1483-1492","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Intrauterine lethality in Tfpi gene disrupted mice is differentially suppressed during mid\u2010 and late\u2010gestation by platelet TFPI\u03b1 overexpression"],"prefix":"10.1016","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9634-9164","authenticated-orcid":false,"given":"Amy E.","family":"Siebert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan A.","family":"Maroney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas D.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3740-0318","authenticated-orcid":false,"given":"Alan E.","family":"Mast","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1111\/jth.15299_bb0010","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1182\/blood.V69.2.645.645","article-title":"Studies of a mechanism inhibiting the initiation of the extrinsic pathway of coagulation","volume":"69","author":"Rao","year":"1987","journal-title":"Blood"},{"key":"10.1111\/jth.15299_bb0015","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1182\/blood-2002-10-3188","article-title":"Low levels of tissue factor pathway inhibitor (TFPI) increase the risk of venous thrombosis","volume":"101","author":"Dahm","year":"2003","journal-title":"Blood"},{"key":"10.1111\/jth.15299_bb0020","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1055\/s-0038-1646439","article-title":"Inhibition of extrinsic pathway inhibitor shortens the coagulation time of normal plasma and of hemophilia plasma","volume":"66","author":"Nordfang","year":"1991","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.15299_bb0025","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1182\/blood.2019001542","article-title":"Subcutaneous concizumab prophylaxis in hemophilia A and hemophilia A\/B with inhibitors: phase 2 trial results","volume":"134","author":"Shapiro","year":"2019","journal-title":"Blood"},{"key":"10.1111\/jth.15299_bb0030","doi-asserted-by":"crossref","first-page":"18832","DOI":"10.1016\/S0021-9258(18)51542-8","article-title":"Purification and characterization of the lipoprotein\u2010associated coagulation inhibitor from human plasma","volume":"264","author":"Novotny","year":"1989","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15299_bb0035","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1182\/blood.V79.12.3219.3219","article-title":"Expression of tissue factor pathway inhibitor by cultured endothelial cells in response to inflammatory mediators","volume":"79","author":"Ameri","year":"1992","journal-title":"Blood"},{"key":"10.1111\/jth.15299_bb0040","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1161\/01.ATV.20.3.874","article-title":"Reversible regulation of tissue factor\u2010induced coagulation by glycosyl phosphatidylinositol\u2010anchored tissue factor pathway inhibitor","volume":"20","author":"Ott","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/jth.15299_bb0045","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1161\/01.ATV.0000042456.84190.F0","article-title":"Characterization of the association of tissue factor pathway inhibitor with human placenta","volume":"22","author":"Mast","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/jth.15299_bb0050","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1182\/blood.V72.6.2020.2020","article-title":"Platelets secrete a coagulation inhibitor functionally and antigenically similar to the lipoprotein associated coagulation inhibitor","volume":"72","author":"Novotny","year":"1988","journal-title":"Blood"},{"key":"10.1111\/jth.15299_bb0055","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1182\/blood-2006-07-037283","article-title":"Active tissue factor pathway inhibitor is expressed on the surface of coated platelets","volume":"109","author":"Maroney","year":"2007","journal-title":"Blood"},{"key":"10.1111\/jth.15299_bb0060","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1111\/j.1538-7836.2008.03033.x","article-title":"Tissue factor pathway inhibitor\u2010gamma is an active alternatively spliced form of tissue factor pathway inhibitor present in mice but not in humans","volume":"6","author":"Maroney","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.15299_bb0065","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1111\/j.1538-7836.2009.03454.x","article-title":"Temporal expression of alternatively spliced forms of tissue factor pathway inhibitor in mice","volume":"7","author":"Maroney","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.15299_bb0070","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1111\/jth.14288","article-title":"Re\u2010evaluation of mouse tissue factor pathway inhibitor and comparison of mouse and human tissue factor pathway inhibitor physiology","volume":"16","author":"Girard","year":"2018","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.15299_bb0075","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/338518a0","article-title":"Functional significance of the Kunitz\u2010type inhibitory domains of lipoprotein\u2010associated coagulation inhibitor","volume":"338","author":"Girard","year":"1989","journal-title":"Nature"},{"key":"10.1111\/jth.15299_bb0080","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1432-1033.1996.0310f.x","article-title":"Inhibitory properties of separate recombinant Kunitz\u2010type\u2010protease\u2010inhibitor domains from tissue\u2010factor\u2010pathway inhibitor","volume":"235","author":"Petersen","year":"1996","journal-title":"Eur J Biochem"},{"key":"10.1111\/jth.15299_bb0085","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1055\/s-0037-1614416","article-title":"TFPIbeta, a second product from the mouse tissue factor pathway inhibitor (TFPI) gene","volume":"81","author":"Chang","year":"1999","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.15299_bb0090","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1073\/pnas.0504240103","article-title":"Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor","volume":"103","author":"Hackeng","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/jth.15299_bb0095","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1182\/blood.V79.8.2004.2004","article-title":"Tissue factor pathway inhibitor: the carboxy\u2010terminus is required for optimal inhibition of factor Xa","volume":"79","author":"Wesselschmidt","year":"1992","journal-title":"Blood"},{"key":"10.1111\/jth.15299_bb0100","doi-asserted-by":"crossref","first-page":"4989","DOI":"10.1021\/bi016058n","article-title":"Contribution of regions distal to glycine\u2010160 to the anticoagulant activity of tissue factor pathway inhibitor","volume":"41","author":"Lockett","year":"2002","journal-title":"Biochemistry"},{"key":"10.1111\/jth.15299_bb0105","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1042\/bj20020696","article-title":"Structural and functional characterization of tissue factor pathway inhibitor following degradation by matrix metalloproteinase\u20108","volume":"367","author":"Cunningham","year":"2002","journal-title":"Biochem J"},{"key":"10.1111\/jth.15299_bb0110","doi-asserted-by":"crossref","first-page":"17838","DOI":"10.1073\/pnas.1310444110","article-title":"Tissue factor pathway inhibitor\u2010alpha inhibits prothrombinase during the initiation of blood coagulation","volume":"110","author":"Wood","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/jth.15299_bb0115","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1182\/bloodadvances.2017011098","article-title":"TFPIalpha interacts with FVa and FXa to inhibit prothrombinase during the initiation of coagulation","volume":"1","author":"Wood","year":"2017","journal-title":"Blood Adv"},{"key":"10.1111\/jth.15299_bb0120","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1111\/jth.14995","article-title":"Platelet anticoagulant proteins: modulators of thrombosis propensity within a procoagulant cell","volume":"18","author":"Siebert","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.15299_bb0125","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1161\/ATVBAHA.110.220293","article-title":"Murine hematopoietic cell tissue factor pathway inhibitor limits thrombus growth","volume":"31","author":"Maroney","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/jth.15299_bb0130","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1073\/pnas.1119858109","article-title":"Absence of hematopoietic tissue factor pathway inhibitor mitigates bleeding in mice with hemophilia","volume":"109","author":"Maroney","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/jth.15299_bb0135","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1182\/blood.V90.3.944","article-title":"Tissue factor pathway inhibitor gene disruption produces intrauterine lethality in mice","volume":"90","author":"Huang","year":"1997","journal-title":"Blood"},{"key":"10.1111\/jth.15299_bb0140","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1182\/blood.2020006054","article-title":"Tissue factor pathway inhibitor is required for cerebrovascular development in mice","volume":"137","author":"Maroney","year":"2021","journal-title":"Blood"},{"key":"10.1111\/jth.15299_bb0145","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1182\/blood-2003-05-1519","article-title":"Factor VIII ectopically expressed in platelets: efficacy in hemophilia A treatment","volume":"102","author":"Yarovoi","year":"2003","journal-title":"Blood"},{"key":"10.1111\/jth.15299_bb0150","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1111\/j.1538-7836.2008.02992.x","article-title":"Platelet\u2010delivered factor VIII provides limited resistance to anti\u2010factor VIII inhibitors","volume":"6","author":"Gewirtz","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.15299_bb0155","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1182\/blood-2015-03-633958","article-title":"A balance between TFPI and thrombin\u2010mediated platelet activation is required for murine embryonic development","volume":"125","author":"Ellery","year":"2015","journal-title":"Blood"},{"key":"10.1111\/jth.15299_bb0160","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1534\/genetics.109.105486","article-title":"A new standard genetic map for the laboratory mouse","volume":"182","author":"Cox","year":"2009","journal-title":"Genetics"},{"key":"10.1111\/jth.15299_bb0165","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1534\/genetics.114.161653","article-title":"Pardo\u2010Manuel de Villena F. High\u2010resolution sex\u2010specific linkage maps of the mouse reveal polarized distribution of crossovers in male germline","volume":"197","author":"Liu","year":"2014","journal-title":"Genetics"},{"key":"10.1111\/jth.15299_bb0170","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1182\/blood-2004-09-3724","article-title":"A balance between tissue factor and tissue factor pathway inhibitor is required for embryonic development and hemostasis in adult mice","volume":"105","author":"Pedersen","year":"2005","journal-title":"Blood"},{"key":"10.1111\/jth.15299_bb0175","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1172\/JCI5678","article-title":"Factor VII deficiency rescues the intrauterine lethality in mice associated with a tissue factor pathway inhibitor deficit","volume":"103","author":"Chan","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1111\/jth.15299_bb0180","first-page":"365","article-title":"Platelet FV deficiency restores survival of TFPI null mice independently of plasma FV","volume":"130","author":"Westrick","year":"2017","journal-title":"Blood"},{"key":"10.1111\/jth.15299_bb0185","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1182\/blood-2009-10-250910","article-title":"Endothelial\u2010derived tissue factor pathway inhibitor regulates arterial thrombosis but is not required for development or hemostasis","volume":"116","author":"White","year":"2010","journal-title":"Blood"},{"key":"10.1111\/jth.15299_bb0190","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1182\/bloodadvances.2018018853","article-title":"Maintaining extraembryonic expression allows generation of mice with severe tissue factor pathway inhibitor deficiency","volume":"3","author":"Castillo","year":"2019","journal-title":"Blood Adv"},{"key":"10.1111\/jth.15299_bb0195","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1182\/blood-2006-06-031898","article-title":"The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis","volume":"109","author":"Tober","year":"2007","journal-title":"Blood"},{"issue":"4","key":"10.1111\/jth.15299_bb0200","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.3324\/haematol.2019.244541","article-title":"Oncogenic Gata1 causes stage\u2010specific megakaryocyte differentiation delay","volume":"106","author":"Juban","year":"2020","journal-title":"Haematologica"},{"key":"10.1111\/jth.15299_bb0205","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/0092-8674(95)90531-6","article-title":"Transcription factor NF\u2010E2 is required for platelet formation independent of the actions of thrombopoietin\/MGDF in megakaryocyte development","volume":"81","author":"Shivdasani","year":"1995","journal-title":"Cell"},{"key":"10.1111\/jth.15299_bb0210","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1242\/dev.059105","article-title":"p45NF\u2010E2 represses Gcm1 in trophoblast cells to regulate syncytium formation, placental vascularization and embryonic growth","volume":"138","author":"Kashif","year":"2011","journal-title":"Development"},{"key":"10.1111\/jth.15299_bb0215","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature26002","article-title":"Placentation defects are highly prevalent in embryonic lethal mouse mutants","volume":"555","author":"Perez\u2010Garcia","year":"2018","journal-title":"Nature"},{"key":"10.1111\/jth.15299_bb0220","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1126\/science.7618084","article-title":"Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype","volume":"269","author":"Threadgill","year":"1995","journal-title":"Science"},{"key":"10.1111\/jth.15299_bb0225","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1534\/genetics.103.020495","article-title":"Phenotypic variation resulting from a deficiency of epidermal growth factor receptor in mice is caused by extensive genetic heterogeneity that can be genetically and molecularly partitioned","volume":"167","author":"Strunk","year":"2004","journal-title":"Genetics"},{"key":"10.1111\/jth.15299_bb0230","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1101\/gr.233866.117","article-title":"Large\u2010scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis","volume":"29","author":"Goodwin","year":"2019","journal-title":"Genome Res"},{"key":"10.1111\/jth.15299_bb0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0168273","article-title":"Platelet full length TFPI\u2010alpha in healthy volunteers is not affected by sex or hormonal use","volume":"12","author":"Winckers","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1111\/jth.15299_bb0240","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/rth2.12058","article-title":"Correlates of plasma and platelet tissue factor pathway inhibitor, factor V, and Protein S","volume":"2","author":"Ellery","year":"2018","journal-title":"Res Pract Thromb Haemost"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.15299","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jth.15299","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622007838?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622007838?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.15299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:31:46Z","timestamp":1761535906000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622007838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S1538783622007838"],"URL":"https:\/\/doi.org\/10.1111\/jth.15299","relation":{},"ISSN":["1538-7836"],"issn-type":[{"type":"print","value":"1538-7836"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intrauterine lethality in Tfpi gene disrupted mice is differentially suppressed during mid\u2010 and late\u2010gestation by platelet TFPI\u03b1 overexpression","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/jth.15299","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}