{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:22:49Z","timestamp":1792592569553,"version":"4.5.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1111\/jth.15817","type":"journal-article","created":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T12:13:55Z","timestamp":1657455235000},"page":"2255-2269","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Characterization of interaction between blood coagulation factor VIII and LRP1 suggests dynamic binding by alternating complex contacts"],"prefix":"10.1016","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2668-6296","authenticated-orcid":false,"given":"Haarin","family":"Chun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7869-0396","authenticated-orcid":false,"given":"James H.","family":"Kurasawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3182-5884","authenticated-orcid":false,"given":"Philip","family":"Olivares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6505-4726","authenticated-orcid":false,"given":"Ekaterina S.","family":"Marakasova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0725-5885","authenticated-orcid":false,"given":"Svetlana A.","family":"Shestopal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2035-4848","authenticated-orcid":false,"given":"Gabriela U.","family":"Hassink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8056-4812","authenticated-orcid":false,"given":"Elena","family":"Karnaukhova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9167-7444","authenticated-orcid":false,"given":"Mary","family":"Migliorini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6851-0096","authenticated-orcid":false,"given":"Juliet O.","family":"Obi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4539-1714","authenticated-orcid":false,"given":"Ally K.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1866-9397","authenticated-orcid":false,"given":"Patrick L.","family":"Wintrode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1538-8349","authenticated-orcid":false,"given":"Prasannavenkatesh","family":"Durai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8783-9495","authenticated-orcid":false,"given":"Keunwan","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6897-6523","authenticated-orcid":false,"given":"Daniel","family":"Deredge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7526-5917","authenticated-orcid":false,"given":"Dudley K.","family":"Strickland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6124-9713","authenticated-orcid":false,"given":"Andrey G.","family":"Sarafanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/jth.15817_bb0010","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1182\/blood.V95.5.1703.005k20_1703_1708","article-title":"Involvement of low\u2010density lipoprotein receptor\u2010related protein (LRP) in the clearance of factor VIII in von Willebrand factor\u2010deficient mice","volume":"95","author":"Schwarz","year":"2000","journal-title":"Blood"},{"key":"10.1111\/jth.15817_bb0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2516.2009.02005.x","article-title":"Factor VIII and von Willebrand factor interaction: biological, clinical and therapeutic importance","volume":"16","author":"Terraube","year":"2010","journal-title":"Haemophilia"},{"key":"10.1111\/jth.15817_bb0020","doi-asserted-by":"crossref","first-page":"8957","DOI":"10.1016\/S0021-9258(18)31537-0","article-title":"Human factor VIIIa subunit structure. Reconstruction of factor VIIIa from the isolated A1\/A3\u2010C1\u2010C2 dimer and A2 subunit","volume":"266","author":"Fay","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15817_bb0025","doi-asserted-by":"crossref","first-page":"e422","DOI":"10.1111\/hae.14313","article-title":"Comparative analysis of the pivotal studies of extended half\u2010life recombinant FVIII products for treatment of haemophilia A","volume":"27","author":"Mannucci","year":"2021","journal-title":"Haemophilia"},{"key":"10.1111\/jth.15817_bb0030","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1182\/blood-2004-11-4230","article-title":"LDL receptor cooperates with LDL receptor\u2010related protein in regulating plasma levels of coagulation factor VIII in vivo","volume":"106","author":"Bovenschen","year":"2005","journal-title":"Blood"},{"key":"10.1111\/jth.15817_bb0035","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1111\/j.1538-7836.2005.01389.x","article-title":"The B domain of coagulation factor VIII interacts with the asialoglycoprotein receptor","volume":"3","author":"Bovenschen","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.15817_bb0040","doi-asserted-by":"crossref","first-page":"23734","DOI":"10.1074\/jbc.274.34.23734","article-title":"The light chain of factor VIII comprises a binding site for low density lipoprotein receptor\u2010related protein","volume":"274","author":"Lenting","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15817_bb0045","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.3324\/haematol.2012.063297","article-title":"Factor VIII and von Willebrand factor are ligands for the carbohydrate\u2010receptor Siglec\u20105","volume":"97","author":"Pegon","year":"2012","journal-title":"Haematologica"},{"key":"10.1111\/jth.15817_bb0050","doi-asserted-by":"crossref","first-page":"37685","DOI":"10.1074\/jbc.274.53.37685","article-title":"Role of the low density lipoprotein\u2010related protein receptor in mediation of factor VIII catabolism","volume":"274","author":"Saenko","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15817_bb0055","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1172\/JCI96400","article-title":"The endothelial cell receptor stabilin\u20102 regulates VWF\u2010FVIII complex half\u2010life and immunogenicity","volume":"128","author":"Swystun","year":"2018","journal-title":"J Clin Invest"},{"key":"10.1111\/jth.15817_bb0060","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1111\/jth.14404","article-title":"The endothelial lectin clearance receptor CLEC4M binds and internalizes factor VIII in a VWF\u2010dependent and independent manner","volume":"17","author":"Swystun","year":"2019","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.15817_bb0065","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1111\/jth.14521","article-title":"The scavenger receptor SCARA5 is an endocytic receptor for von Willebrand factor expressed by littoral cells in the human spleen","volume":"17","author":"Swystun","year":"2019","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.15817_bb0070","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1182\/blood-2017-06-787853","article-title":"A novel role for the macrophage galactose\u2010type lectin receptor in mediating von Willebrand factor clearance","volume":"131","author":"Ward","year":"2018","journal-title":"Blood"},{"key":"10.1111\/jth.15817_bb0075","doi-asserted-by":"crossref","first-page":"728","DOI":"10.3324\/haematol.2017.175216","article-title":"Macrophage scavenger\u2010receptor SR\u2010AI contributes to the clearance of von Willebrand factor","volume":"103","author":"Wohner","year":"2018","journal-title":"Haematologica"},{"key":"10.1111\/jth.15817_bb0080","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1182\/blood-2002-07-2081","article-title":"Elevated plasma factor VIII in a mouse model of low\u2010density lipoprotein receptor\u2010related protein deficiency","volume":"101","author":"Bovenschen","year":"2003","journal-title":"Blood"},{"key":"10.1111\/jth.15817_bb0085","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/41672","article-title":"LDL\u2010receptor structure. Calcium cages, acid baths and recycling receptors","volume":"388","author":"Brown","year":"1997","journal-title":"Nature"},{"key":"10.1111\/jth.15817_bb0090","doi-asserted-by":"crossref","first-page":"197","DOI":"10.5535\/arm.2017.41.2.197","article-title":"Association between a polymorphism in CASP3 and CASP9 genes and ischemic stroke","volume":"41","author":"Lee","year":"2017","journal-title":"Ann Rehabil Med"},{"key":"10.1111\/jth.15817_bb0095","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1538-7836.2007.02337.x","article-title":"Low\u2010density lipoprotein receptor\u2010related protein 1 polymorphism 663 C > T affects clotting factor VIII activity and increases the risk of venous thromboembolism","volume":"5","author":"Vormittag","year":"2007","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.15817_bb0100","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.thromres.2022.03.021","article-title":"Pleiotropic effects of PCSK9\u2010inhibition on hemostasis: anti\u2010PCSK9 reduce FVIII levels by enhancing LRP1 expression","volume":"213","author":"Paciullo","year":"2022","journal-title":"Thromb Res"},{"key":"10.1111\/jth.15817_bb0105","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.biocel.2017.05.027","article-title":"Cellular uptake of coagulation factor VIII: elusive role of the membrane\u2010binding spikes in the C1 domain","volume":"89","author":"Castro\u2010Nunez","year":"2017","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1111\/jth.15817_bb0110","doi-asserted-by":"crossref","first-page":"11970","DOI":"10.1074\/jbc.M008046200","article-title":"Cell surface heparan sulfate proteoglycans participate in factor VIII catabolism mediated by low density lipoprotein receptor\u2010related protein","volume":"276","author":"Sarafanov","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15817_bb0115","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.thromres.2010.04.004","article-title":"The \"normal\" factor VIII concentration in plasma","volume":"126","author":"Butenas","year":"2010","journal-title":"Thromb Res"},{"key":"10.1111\/jth.15817_bb0120","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1515\/bc.2010.129","article-title":"Lipoprotein receptors\u2010\u2010an evolutionarily ancient multifunctional receptor family","volume":"391","author":"Dieckmann","year":"2010","journal-title":"Biol Chem"},{"key":"10.1111\/jth.15817_bb0125","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1152\/physrev.00033.2007","article-title":"LDL receptor\u2010related protein 1: unique tissue\u2010specific functions revealed by selective gene knockout studies","volume":"88","author":"Lillis","year":"2008","journal-title":"Physiol Rev"},{"key":"10.1111\/jth.15817_bb0130","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1007\/s00018-004-4090-3","article-title":"Low\u2010density lipoprotein receptor structure and folding","volume":"61","author":"Gent","year":"2004","journal-title":"Cell Mol Life Sci"},{"key":"10.1111\/jth.15817_bb0135","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1146\/annurev.bi.63.070194.003125","article-title":"Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor\u2010related protein (LRP)","volume":"63","author":"Krieger","year":"1994","journal-title":"Annu Rev Biochem"},{"key":"10.1111\/jth.15817_bb0140","doi-asserted-by":"crossref","first-page":"8356537","DOI":"10.1155\/2017\/8356537","article-title":"The LDL receptor\u2010related protein 1: at the crossroads of lipoprotein metabolism and insulin signaling","volume":"2017","author":"Au","year":"2017","journal-title":"J Diabetes Res"},{"key":"10.1111\/jth.15817_bb0145","doi-asserted-by":"crossref","first-page":"100715","DOI":"10.1016\/j.jbc.2021.100715","article-title":"Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism","volume":"296","author":"Cooper","year":"2021","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15817_bb0150","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.3390\/ijms19103090","article-title":"The reelin receptors apolipoprotein E receptor 2 (ApoER2) and VLDL receptor","volume":"19","author":"Dlugosz","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1111\/jth.15817_bb0155","first-page":"19","article-title":"Low\u2010density lipoprotein receptor (LDLR) family orchestrates cholesterol homeostasis","volume":"85","author":"Go","year":"2012","journal-title":"Yale J Biol Med"},{"key":"10.1111\/jth.15817_bb0160","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.neuron.2014.08.005","article-title":"More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration","volume":"83","author":"Lane\u2010Donovan","year":"2014","journal-title":"Neuron"},{"key":"10.1111\/jth.15817_bb0165","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/MBC.0b013e3282f5457b","article-title":"The binding sites for the very low density lipoprotein receptor and low\u2010density lipoprotein receptor\u2010related protein are shared within coagulation factor VIII","volume":"19","author":"Ananyeva","year":"2008","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1111\/jth.15817_bb0170","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/MBC.0b013e3283068859","article-title":"Interaction of coagulation factor VIII with members of the low\u2010density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484\u2010509","volume":"19","author":"Ananyeva","year":"2008","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1111\/jth.15817_bb0175","doi-asserted-by":"crossref","first-page":"39484","DOI":"10.1074\/jbc.M104382200","article-title":"Recognition of alpha 2\u2010macroglobulin by the low density lipoprotein receptor\u2010related protein requires the cooperation of two ligand binding cluster regions","volume":"276","author":"Mikhailenko","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15817_bb0180","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.3390\/ijms19061780","article-title":"The role of low\u2010density lipoprotein receptor\u2010related protein 1 in lipid metabolism, glucose homeostasis and inflammation","volume":"19","author":"Actis Dato","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1111\/jth.15817_bb0185","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/41798","article-title":"Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module","volume":"388","author":"Fass","year":"1997","journal-title":"Nature"},{"key":"10.1111\/jth.15817_bb0190","doi-asserted-by":"crossref","first-page":"16629","DOI":"10.1074\/jbc.M400157200","article-title":"The role of a conserved acidic residue in calcium\u2010dependent protein folding for a low density lipoprotein (LDL)\u2010a module: implications in structure and function for the LDL receptor superfamily","volume":"279","author":"Guo","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15817_bb0195","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.molcel.2006.02.021","article-title":"Structure of an LDLR\u2010RAP complex reveals a general mode for ligand recognition by lipoprotein receptors","volume":"22","author":"Fisher","year":"2006","journal-title":"Mol Cell"},{"key":"10.1111\/jth.15817_bb0200","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nsmb753","article-title":"X\u2010ray structure of a minor group human rhinovirus bound to a fragment of its cellular receptor protein","volume":"11","author":"Verdaguer","year":"2004","journal-title":"Nat Struct Mol Biol"},{"key":"10.1111\/jth.15817_bb0205","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.str.2010.01.010","article-title":"Structural basis for specific recognition of reelin by its receptors","volume":"18","author":"Yasui","year":"2010","journal-title":"Structure"},{"key":"10.1111\/jth.15817_bb0210","doi-asserted-by":"crossref","first-page":"22218","DOI":"10.1074\/jbc.271.36.22218","article-title":"Receptor\u2010associated protein is a folding chaperone for low density lipoprotein receptor\u2010related protein","volume":"271","author":"Bu","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15817_bb0215","doi-asserted-by":"crossref","first-page":"21232","DOI":"10.1016\/S0021-9258(18)54845-6","article-title":"39\u2010kDa protein modulates binding of ligands to low density lipoprotein receptor\u2010related protein\/alpha 2\u2010macroglobulin receptor","volume":"266","author":"Herz","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15817_bb0220","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1042\/bj3410377","article-title":"39\u2010kDa receptor\u2010associated protein (RAP) facilitates secretion and ligand binding of extracellular region of very\u2010low\u2010density\u2010lipoprotein receptor: implications for a distinct pathway from low\u2010density\u2010lipoprotein receptor","volume":"341","author":"Sato","year":"1999","journal-title":"Biochem J"},{"key":"10.1111\/jth.15817_bb0225","doi-asserted-by":"crossref","first-page":"21017","DOI":"10.1074\/jbc.M000507200","article-title":"Identification of the minimal functional unit in the low density lipoprotein receptor\u2010related protein for binding the receptor\u2010 associated protein (RAP). A conserved acidic residue in the complement\u2010 type repeats is important for recognition of RAP","volume":"275","author":"Andersen","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15817_bb0230","doi-asserted-by":"crossref","first-page":"100842","DOI":"10.1016\/j.jbc.2021.100842","article-title":"Molecular chaperone RAP interacts with LRP1 in a dynamic bivalent mode and enhances folding of ligand\u2010binding regions of other LDLR family receptors","volume":"297","author":"Marakasova","year":"2021","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15817_bb0235","doi-asserted-by":"crossref","first-page":"26035","DOI":"10.1074\/jbc.M116.754622","article-title":"Evidence that factor VIII forms a bivalent complex with the low density lipoprotein (LDL) receptor\u2010related protein 1 (LRP1): identification of cluster IV on LRP1 as the major binding site","volume":"291","author":"Young","year":"2016","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15817_bb0240","doi-asserted-by":"crossref","first-page":"16463","DOI":"10.1074\/jbc.M115.650911","article-title":"Factor VIII interacts with the endocytic receptor low\u2010density lipoprotein receptor\u2010related protein 1 via an extended surface comprising \"hot\u2010spot\" lysine residues","volume":"290","author":"van den Biggelaar","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15817_bb0245","doi-asserted-by":"crossref","first-page":"31305","DOI":"10.1074\/jbc.274.44.31305","article-title":"The second and fourth cluster of class a cysteine\u2010rich repeats of the low density lipoprotein receptor\u2010related protein share ligand\u2010binding properties","volume":"274","author":"Neels","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15817_bb0250","doi-asserted-by":"crossref","first-page":"9370","DOI":"10.1074\/jbc.M212053200","article-title":"Low density lipoprotein receptor\u2010related protein and factor IXa share structural requirements for binding to the A3 domain of coagulation factor VIII","volume":"278","author":"Bovenschen","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15817_bb0255","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.bbapap.2007.04.003","article-title":"Functional duplication of ligand\u2010binding domains within low\u2010density lipoprotein receptor\u2010related protein for interaction with receptor associated protein, alpha(2)\u2010macroglobulin, factor IXa and factor VIII","volume":"1774","author":"Meijer","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.1111\/jth.15817_bb0260","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1021\/bi5011688","article-title":"Cluster III of low\u2010density lipoprotein receptor\u2010related protein 1 binds activated blood coagulation factor VIII","volume":"54","author":"Kurasawa","year":"2015","journal-title":"Biochemistry"},{"key":"10.1111\/jth.15817_bb0265","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1365-2516.2009.02135.x","article-title":"Purification and characterization of a new recombinant factor VIII (N8)","volume":"16","author":"Thim","year":"2010","journal-title":"Haemophilia"},{"key":"10.1111\/jth.15817_bb0270","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.pep.2012.12.008","article-title":"Insect cell\u2010based expression and characterization of a single\u2010chain variable antibody fragment directed against blood coagulation factor VIII","volume":"88","author":"Kurasawa","year":"2013","journal-title":"Protein Expr Purif"},{"key":"10.1111\/jth.15817_bb0275","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1083\/jcb.110.4.1041","article-title":"The human alpha 2\u2010macroglobulin receptor: identification of a 420\u2010kD cell surface glycoprotein specific for the activated conformation of alpha 2\u2010macroglobulin","volume":"110","author":"Ashcom","year":"1990","journal-title":"J Cell Biol"},{"key":"10.1111\/jth.15817_bb0280","doi-asserted-by":"crossref","first-page":"12001","DOI":"10.1038\/s41598-017-11961-z","article-title":"Organ\u2010specific regulation of ATP7A abundance is coordinated with systemic copper homeostasis","volume":"7","author":"Chun","year":"2017","journal-title":"Sci Rep"},{"key":"10.1111\/jth.15817_bb0285","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/jth.15257","article-title":"Characterization of protein unable to bind von Willebrand factor in recombinant factor VIII products","volume":"19","author":"Chun","year":"2021","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.15817_bb0290","doi-asserted-by":"crossref","first-page":"22033","DOI":"10.1074\/jbc.M113.468108","article-title":"Mapping the binding region on the low density lipoprotein receptor for blood coagulation factor VIII","volume":"288","author":"Kurasawa","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15817_bb0295","doi-asserted-by":"crossref","first-page":"779100","DOI":"10.3389\/fimmu.2021.779100","article-title":"Molecular basis of selective cytokine signaling inhibition by antibodies targeting a shared receptor","volume":"12","author":"Fields","year":"2021","journal-title":"Front Immunol"},{"key":"10.1111\/jth.15817_bb0300","doi-asserted-by":"crossref","first-page":"101808","DOI":"10.1016\/j.jbc.2022.101808","article-title":"A fusion of the Bacteroides fragilis ferrous iron import proteins reveals a role for FeoA in stabilizing GTP\u2010bound FeoB","volume":"298","author":"Sestok","year":"2022","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15817_bb0305","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/cpbi.3","article-title":"Comparative protein structure modeling using MODELLER","volume":"54","author":"Webb","year":"2016","journal-title":"Curr Protoc Bioinformatics"},{"key":"10.1111\/jth.15817_bb0310","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jmb.2010.11.008","article-title":"Alternate states of proteins revealed by detailed energy landscape mapping","volume":"405","author":"Tyka","year":"2011","journal-title":"J Mol Biol"},{"key":"10.1111\/jth.15817_bb0315","doi-asserted-by":"crossref","first-page":"29670","DOI":"10.1074\/jbc.M113.473116","article-title":"Factor VIII C1 domain spikes 2092\u20102093 and 2158\u20102159 comprise regions that modulate cofactor function and cellular uptake","volume":"288","author":"Bloem","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15817_bb0320","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1042\/bj3570289","article-title":"Analysis of a two\u2010domain binding site for the urokinase\u2010type plasminogen activator\u2010plasminogen activator inhibitor\u20101 complex in low\u2010density\u2010lipoprotein\u2010receptor\u2010related protein","volume":"357","author":"Andersen","year":"2001","journal-title":"Biochem J"},{"key":"10.1111\/jth.15817_bb0325","doi-asserted-by":"crossref","first-page":"24081","DOI":"10.1074\/jbc.M113.473728","article-title":"Quantitative dissection of the binding contributions of ligand lysines of the receptor\u2010associated protein (RAP) to the low density lipoprotein receptor\u2010related protein (LRP1)","volume":"288","author":"Dolmer","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15817_bb0330","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/978-1-62703-398-5_6","article-title":"Protein\u2010ligand interactions using SPR systems","volume":"1008","author":"Frostell","year":"2013","journal-title":"Methods Mol Biol"},{"key":"10.1111\/jth.15817_bb0335","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1074\/jbc.RA119.010449","article-title":"High\u2010affinity binding of plasminogen\u2010activator inhibitor 1 complexes to LDL receptor\u2010related protein 1 requires lysines 80, 88, and 207","volume":"295","author":"Migliorini","year":"2020","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15817_bb0340","doi-asserted-by":"crossref","first-page":"18430","DOI":"10.1074\/jbc.M116.744904","article-title":"High affinity binding of the receptor\u2010associated protein D1D2 domains with the low density lipoprotein receptor\u2010related protein (LRP1) involves bivalent complex formation: critical roles of Lysines 60 and 191","volume":"291","author":"Prasad","year":"2016","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.15817_bb0345","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.biocel.2010.11.017","article-title":"A single lysine of the two\u2010lysine recognition motif of the D3 domain of receptor\u2010associated protein is sufficient to mediate endocytosis by low\u2010density lipoprotein receptor\u2010related protein","volume":"43","author":"van den Biggelaar","year":"2011","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1111\/jth.15817_bb0350","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1056\/NEJMoa2002699","article-title":"BIVV001 fusion protein as factor VIII replacement therapy for hemophilia a","volume":"383","author":"Konkle","year":"2020","journal-title":"N Engl J Med"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.15817","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jth.15817","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622190501?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622190501?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.15817","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jth.15817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:35:14Z","timestamp":1761536114000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622190501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":69,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S1538783622190501"],"URL":"https:\/\/doi.org\/10.1111\/jth.15817","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of interaction between blood coagulation factor VIII and LRP1 suggests dynamic binding by alternating complex contacts","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/jth.15817","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2022 The Authors. Journal of Thrombosis and Haemostasis published by ELSEVIER INC. on behalf of International Society on Thrombosis and Haemostasis","name":"copyright","label":"Copyright"}]}}