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This cross\u2010sectional study included 204 non\u2010institutionalized elderly (&gt;60\u2009years; 123 women\/81 men), free of severe disabilities and non\u2010alcohol\/tobacco consumers, from whom specific pharmacological therapies were evaluated, as well xerostomia (Xerostomia Inventory\u2010XI) and swallowing complaints (EAT\u201010 questionnaire), salivary flow rate and gustatory sensitivity. Statistical analysis included Chi\u2010square, Mann\u2013Whitney, Two\u2010way ANCOVA, and linear multiple regression. Polypharmacy (\u22655 drugs daily), hyposalivation, and severe taste dysfunction were found in 18, 46, and 10% of the participants, respectively. Polypharmacy was related with xerostomia (<jats:italic>p<\/jats:italic> =\u2009.041) and swallowing complaints (<jats:italic>p<\/jats:italic> &lt;\u2009.001; power = 94%), but not with taste dysfunction. Dry mouth complaint and higher risk of swallowing disorders were found in 50 and 12% of the elderly, respectively, and angiotensin\u2010converting enzyme (ACE) inhibitors users (<jats:italic>n<\/jats:italic> =\u200936) showed higher EAT\u201010 scores (<jats:italic>p<\/jats:italic> =\u2009.038). Regression models showed that stimulated salivary flow rate was dependent on gender and diuretic use, while xerostomia scores were dependent on the number of medications and unstimulated saliva flow (<jats:italic>p<\/jats:italic> &lt;\u2009.001). In conclusion, the results draw attention to the high frequency of oral and maxillofacial dysfunctions found in non\u2010institutionalized elderly, especially polypharmacy, xerostomia and swallowing complaints, and the side effects of drugs that can disturb the oral functions, the acceptance of food, and the adherence to oral therapies.<\/jats:p>","DOI":"10.1111\/jtxs.12573","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T06:21:49Z","timestamp":1605507709000},"page":"187-196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Relationship between polypharmacy, xerostomia, gustatory sensitivity, and swallowing complaints in the elderly: A multidisciplinary approach"],"prefix":"10.1111","volume":"52","author":[{"given":"Mariana S.","family":"Fernandes","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry University of Campinas  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8703-2272","authenticated-orcid":false,"given":"Paula M.","family":"Castelo","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Universidade Federal de S\u00e3o Paulo  Diadema Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna N.","family":"Chaves","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Universidade Federal de S\u00e3o Paulo  Diadema Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o P. 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