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The purpose of this study was to clarify the clinicopathologic characteristics and surgical outcomes of patients with <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010associated <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>. All patients with chronic <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> infection were identified from a database of patients with <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> that underwent surgical resection between 1 <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 2005 and 31 <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2006. Their clinicopathologic and survival characteristics were compared with <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> patients without chronic <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> infection. The age of the <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010associated <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> patients tend to be younger than that of <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> patients without chronic <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> infection. <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010associated <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> patients tend to have higher abnormal \u03b1\u2010fetoprotein levels and lower abnormal serum carbohydrate antigen19\u20109 (<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>19\u20109), r\u2010glutamyltransferase (r\u2010<jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>) and alkaline phosphatase levels. The pathologic features of the resected specimens revealed that <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010associated <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> patients tended to be of the mass\u2010forming type have a lower prevalence of lymphatic involvement and poorer tumour differentiation, and a higher prevalence of capsule formation and liver cirrhosis. Patients with <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010associated <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> had a significantly better survival than patients without chronic <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> infection. The clinicopathological features of <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010associated <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> patients showed significant differences from <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> patients without <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> infection. These tumours are characterized by the mass\u2010forming growth pattern and appeared to have a more favourable prognosis.<\/jats:p>","DOI":"10.1111\/jvh.12005","type":"journal-article","created":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T06:03:10Z","timestamp":1347516190000},"page":"306-310","source":"Crossref","is-referenced-by-count":35,"title":["Characteristics of intrahepatic cholangiocarcinoma in patients with hepatitis <scp>B<\/scp> virus infection: clinicopathologic study of resected tumours"],"prefix":"10.1111","volume":"20","author":[{"given":"Z.\u2010F.","family":"Wu","sequence":"first","affiliation":[{"name":"Fifth Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Yang","sequence":"additional","affiliation":[{"name":"Fifth Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.\u2010Y.","family":"Li","sequence":"additional","affiliation":[{"name":"Fifth Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u2010B.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fifth Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.\u2010S.","family":"Yang","sequence":"additional","affiliation":[{"name":"Fifth Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-828889"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00288-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2002.02143.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328224b935"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000601)88:11<2471::AID-CNCR7>3.0.CO;2-T"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01796.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000091446"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605063"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.02.005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21121"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9071(200010)62:2<151::AID-JMV5>3.0.CO;2-N"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.25087"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(01)01016-X"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e328337c899"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/scbi.1998.0087"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2005.05.028"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00072.2008"},{"key":"e_1_2_8_19_1","first-page":"277","article-title":"Clinicopathologic features and results of surgical treatment. 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