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Therefore, alternative antiviral drugs that efficiently block virus production are needed. During recent decades, <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> interference (<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>i) technology has not only become a powerful tool for functional genomics but also represents a new therapeutic approach for treating human diseases including viral infections. <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>i is a sequence\u2010specific and post\u2010transcriptional gene silencing process mediated by double\u2010stranded <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> (ds<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>). As the <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> genome is a single\u2010stranded <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> that functions as both a messenger <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>) and replication template, it is an attractive target for the study of <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>i\u2010based viral therapies. In this review, we will give a brief overview about the history and current status of <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>i and focus on its potential application as a therapeutic option for treatment for <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection.<\/jats:p>","DOI":"10.1111\/jvh.12006","type":"journal-article","created":{"date-parts":[[2012,10,9]],"date-time":"2012-10-09T11:02:09Z","timestamp":1349780529000},"page":"757-765","source":"Crossref","is-referenced-by-count":21,"title":["Therapeutic potential of <scp>RNA<\/scp> interference: a new molecular approach to antiviral treatment for hepatitis <scp>C<\/scp>"],"prefix":"10.1111","volume":"19","author":[{"given":"M.","family":"Motavaf","sequence":"first","affiliation":[{"name":"Tehran Hepatitis Center (THC) Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Safari","sequence":"additional","affiliation":[{"name":"Tehran Hepatitis Center (THC) Tehran Iran"},{"name":"Department of Anesthesiology and Pain Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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