{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:04:55Z","timestamp":1781003095414,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T00:00:00Z","timestamp":1353369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To study the role of heat shock protein A1L (<jats:styled-content style=\"fixed-case\">HSPA<\/jats:styled-content>1L) and A1B (<jats:styled-content style=\"fixed-case\">HSPA<\/jats:styled-content>1B) polymorphisms and subsequent risk of hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>) in India. Subjects enrolled included 185 cases of <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>, 182 cases of chronic hepatitis (<jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content>) and 200 healthy controls. Genomic <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> was typed for <jats:styled-content style=\"fixed-case\">HSPA<\/jats:styled-content>1L2437 and <jats:styled-content style=\"fixed-case\">HSPA<\/jats:styled-content>1B1267 <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> using polymerase chain reaction with restriction fragment length polymorphism. Other risk factors were also analysed. Hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> virus (<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>) infection, older age &gt;35\u00a0years and high aflatoxin level in urine increased the risk of <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>. The frequencies of <jats:styled-content style=\"fixed-case\">HSPA<\/jats:styled-content>1L <jats:styled-content style=\"fixed-case\">BB<\/jats:styled-content> genotype and B allele in <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> were more than in <jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content> [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>): 9.83; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.000], but also in <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010related <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> than Chronic Hepatitis B (CHB) [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 3.44; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004] and <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010related <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> compared to <jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content> [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 6.32; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.010]. The frequency of <jats:styled-content style=\"fixed-case\">HSPA<\/jats:styled-content>1B genotype in the homozygous state was more in <jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content> [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 6.01; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001] and is a good marker to predict the risk of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010related <jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>) compared to controls. <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010related <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> has a higher frequency of the B allele of <jats:styled-content style=\"fixed-case\">HSPA<\/jats:styled-content>1B than healthy controls [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 3.95; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.000] and <jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content> [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 2.35; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.000], respectively. The frequencies increased further significantly in <jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content> compared to healthy controls [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 9.26; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.000]. The risk for the development of <jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> compared to healthy controls irrespective of the aetiology was significant in terms of the <jats:styled-content style=\"fixed-case\">HSPA<\/jats:styled-content>1B marker than <jats:styled-content style=\"fixed-case\">HSPA<\/jats:styled-content>1L in the Indian population.<\/jats:p>","DOI":"10.1111\/jvh.12021","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T13:52:05Z","timestamp":1353419525000},"source":"Crossref","is-referenced-by-count":11,"title":["<scp>G<\/scp>enetic variants of heat shock protein A1L2437 and A1B1267 as possible risk factors for hepatocellular carcinoma in <scp>I<\/scp>ndia"],"prefix":"10.1111","volume":"20","author":[{"given":"S.","family":"Medhi","sequence":"first","affiliation":[{"name":"Department of Medicine Maulana Azad Medical College University of Delhi New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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