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Recent studies have shown that hepatitis <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> is also an issue in developed countries. In this setting, hepatitis <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> is a zoonotic infection and causes acute infection mainly in middle\u2010aged and elderly men; and chronic infection in the immunosuppressed. The scope and burden of disease are still emerging. 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