{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:44:46Z","timestamp":1790315086191,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,12,5]],"date-time":"2012-12-05T00:00:00Z","timestamp":1354665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["2008-50"],"award-info":[{"award-number":["2008-50"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Returned Personnel Science Research Project of Shanxi Province, China","award":["HD70324-01"],"award-info":[{"award-number":["HD70324-01"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Little is known about the risk factors associated with hepatitis B virus (<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>) intrauterine transmission among <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg\u2010positive mothers. We conducted a study in Taiyuan, China, including 1133 <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg\u2010positive mothers and their babies. A total of 101 neonates had <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg and\/or <jats:styled-content style=\"fixed-case\">HBV DNA<\/jats:styled-content> positive with an intrauterine transmission rate of 8.9%. Maternal menstrual irregularity (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a04.95, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.71, 14.33) and severe nausea during the first trimester (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.86, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.11, 3.09) were associated with an increased risk of intrauterine transmission, while caesarean delivery (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.32, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.20, 0.51) was associated with a decreased risk after adjusting for potential confounders. Maternal <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>eAg positive was a strong independent predictor for intrauterine transmission (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.56, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.54, 4.27). A positive association between maternal <jats:styled-content style=\"fixed-case\">HBV DNA<\/jats:styled-content> levels and intrauterine transmission was suggested. Maternal <jats:styled-content style=\"fixed-case\">HBIG<\/jats:styled-content> administration during pregnancy, family history of <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> infection and premature rupture of membranes was not associated with the risk of intrauterine transmission. The study confirmed that maternal <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>eAg positive was a risk factor and caesarean delivery was a protective factor for intrauterine transmission. The new findings associated with menstrual irregularity and severe nausea during the first trimester warrant further investigation.<\/jats:p>","DOI":"10.1111\/jvh.12032","type":"journal-article","created":{"date-parts":[[2012,12,6]],"date-time":"2012-12-06T01:58:34Z","timestamp":1354759114000},"page":"317-321","source":"Crossref","is-referenced-by-count":56,"title":["Risk factors of <scp>HBV<\/scp> intrauterine transmission among <scp>HB<\/scp>sAg\u2010positive pregnant women"],"prefix":"10.1111","volume":"20","author":[{"given":"Z.","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Epidemiology School of Public Health Shanxi Medical University Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. H.","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health Shanxi Medical University Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. L.","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health Shanxi Medical University Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Wang","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department the Third People Hospital of Taiyuan City Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L .P.","family":"Feng","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department the Third People Hospital of Taiyuan City Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. P.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health Shanxi Medical University Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. W.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health Shanxi Medical University Taiyuan Shanxi China"},{"name":"Yale School of Public Health School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,5]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization.Hepatitis B. WHO Fact Sheet 204 (Revised July 2012). 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