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Hepatic steatosis is most common in patients infected with genotype 3 viruses, possibly due to direct effects of genotype 3 viral proteins. Hepatic steatosis in patients infected with other genotypes is thought to be mostly due to changes in host metabolism, involving insulin resistance in particular. Specific effects of the <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> genotype 3 core proteins have been observed in cellular models <jats:italic>in vitro<\/jats:italic>: mechanisms linked with a decrease in microsomal triglyceride transfer protein activity, decreases in the levels of peroxisome proliferator\u2010activating receptors, increases in the levels of sterol regulatory element\u2010binding proteins, and phosphatase and tensin homologue downregulation. Functional differences between the core proteins of genotype 3 viruses and viruses of other genotypes may reflect differences in amino acid sequences. However, bioclinical studies have failed to identify specific \u2018steatogenic\u2019 sequences in <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> isolates from patients with hepatic steatosis. It is therefore difficult to distinguish between viral and metabolic steatosis unambiguously, and host and viral factors are probably involved in both <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> genotype 3 and nongenotype 3 steatosis.<\/jats:p>","DOI":"10.1111\/jvh.12035","type":"journal-article","created":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T11:36:45Z","timestamp":1354189005000},"page":"77-84","source":"Crossref","is-referenced-by-count":44,"title":["Hepatitis C virus diversity and hepatic steatosis"],"prefix":"10.1111","volume":"20","author":[{"given":"P.","family":"Roingeard","sequence":"first","affiliation":[{"name":"INSERM U966 Universit\u00e9 Fran\u00e7ois Rabelais &amp; CHRU de Tours Tours 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