{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T21:03:19Z","timestamp":1770066199543,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The patatin\u2010like phospholipase domain\u2010containing 3 gene (<jats:styled-content style=\"fixed-case\">PNPLA<\/jats:styled-content>3) and the apolipoprotein C3 gene (<jats:styled-content style=\"fixed-case\">APOC<\/jats:styled-content>3) have been studied in relation to liver steatosis and liver disease outcome. The aim of this study was to evaluate the influence of <jats:styled-content style=\"fixed-case\">PNPLA<\/jats:styled-content>3 p.I148M and <jats:styled-content style=\"fixed-case\">APOC<\/jats:styled-content>3 rs2854116 and rs2854117 polymorphisms on the clinical and histological presentation of chronic hepatitis C in an Italian population and their relationship with viral and anthropometric parameters. Patients with hepatitis C (<jats:italic>n<\/jats:italic>\u00a0=\u00a0166) entered the study receiving a clinical, histological, virological and biochemical evaluation. <jats:styled-content style=\"fixed-case\">APOC<\/jats:styled-content>3 (rs2854116 and rs2854117) and <jats:styled-content style=\"fixed-case\">PNPLA<\/jats:styled-content>3 (p.I148M) variants were genotyped. <jats:styled-content style=\"fixed-case\">PNPLA<\/jats:styled-content>3 polymorphisms were associated with liver steatosis, which was significantly higher in patients with p.148I\/M (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.034) and p.148M\/M (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004) variants than those homozygous for the <jats:styled-content style=\"fixed-case\">PNPLA<\/jats:styled-content>3 wild type. Excluding patients with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> genotype 3, the association with liver steatosis and <jats:styled-content style=\"fixed-case\">PNPLA<\/jats:styled-content>3 variants was more marked (p.148I\/I genotype vs p.148I\/M, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02, and vs p.148M\/M, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005). The <jats:styled-content style=\"fixed-case\">APOC<\/jats:styled-content>3 polymorphism was not associated with any of the evaluated parameters. Among the interacting factors, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> and waist circumference correlated with liver steatosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.008 and 0.004, respectively). Relationship between waist circumference and liver steatosis was analysed for the different <jats:styled-content style=\"fixed-case\">PNPLA<\/jats:styled-content>3 genotypes. Homozygous 148M patients showed a stronger correlation between waist circumference and steatosis than those carrying the other genotypes (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0047). In our hepatitis C\u2010infected population, the <jats:styled-content style=\"fixed-case\">PNPLA<\/jats:styled-content>3 polymorphism influenced the development of liver steatosis, but not fibrosis progression. <jats:styled-content style=\"fixed-case\">APOC<\/jats:styled-content>3 polymorphisms had no effect on the development of steatosis and no influence on the <jats:styled-content style=\"fixed-case\">PNPLA<\/jats:styled-content>3 polymorphism. The amount of abdominal fat can increase the association of <jats:styled-content style=\"fixed-case\">PNPLA<\/jats:styled-content>3 p.I148M with liver steatosis.<\/jats:p>","DOI":"10.1111\/jvh.12053","type":"journal-article","created":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T16:07:53Z","timestamp":1357574873000},"page":"517-523","source":"Crossref","is-referenced-by-count":42,"title":["Abdominal fat interacts with <scp>PNPLA<\/scp>3 I148M, but not with the <scp>APOC<\/scp>3 variant in the pathogenesis of liver steatosis in chronic hepatitis C"],"prefix":"10.1111","volume":"20","author":[{"given":"R.","family":"Zampino","sequence":"first","affiliation":[{"name":"Internal Medicine and Hepatology Second University of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Coppola","sequence":"additional","affiliation":[{"name":"Department of Public Medicine Section of Infectious Diseases Second University of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Cirillo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Second University of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Boemio","sequence":"additional","affiliation":[{"name":"Internal Medicine and Hepatology Second University of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Pisaturo","sequence":"additional","affiliation":[{"name":"Department of Public Medicine Section of Infectious Diseases Second University of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Marrone","sequence":"additional","affiliation":[{"name":"Internal Medicine and Hepatology Second University of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Macera","sequence":"additional","affiliation":[{"name":"Department of Public Medicine Section of Infectious Diseases Second University of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Sagnelli","sequence":"additional","affiliation":[{"name":"Department of Public Medicine Section of Infectious Diseases Second University of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Perrone","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Second University of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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