{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:17:34Z","timestamp":1791152254042,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T00:00:00Z","timestamp":1362355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"crossref","award":["2012ZX10002004"],"award-info":[{"award-number":["2012ZX10002004"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Sun Yat-Sen University Clinical Research 5010 Program","award":["2007029"],"award-info":[{"award-number":["2007029"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81202319"],"award-info":[{"award-number":["81202319"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Fund of Guangdong Province","award":["S2012040008104"],"award-info":[{"award-number":["S2012040008104"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2013,4]]},"abstract":"Summary<\/jats:title>\n \n The aim of this study was to investigate the efficacy of sequential use of telbivudine in hepatitis\n B<\/jats:styled-content>\n e antigen (\n HB<\/jats:styled-content>\n eAg)\u2010positive chronic hepatitis\n B<\/jats:styled-content>\n patients with partial responses to pegylated interferon. Patients with partial responses to 48\u00a0weeks of pegylated interferon treatment were divided into two groups. In group\n A<\/jats:styled-content>\n , patients stopped pegylated interferon directly without sequential treatment. In group\n B<\/jats:styled-content>\n , patients received sequential treatment with telbivudine 600\u00a0mg\/day.\n HB<\/jats:styled-content>\n eAg,\n HB<\/jats:styled-content>\n eAb, hepatitis B virus (\n HBV<\/jats:styled-content>\n )\n DNA<\/jats:styled-content>\n , alanine aminotransferase (\n ALT<\/jats:styled-content>\n ) and creatine kinase levels were determined at baseline and at weeks 12, 24, 36 and 48. Responses and safety were assessed after 48\u00a0weeks of telbivudine treatment. Thirty\u2010six patients were recruited. Eighteen of these patients stopped pegylated interferon without sequential treatment (group\n A<\/jats:styled-content>\n ). After 48\u00a0weeks of follow\u2010up, five patients (28%) had undergone\n HB<\/jats:styled-content>\n e\n A<\/jats:styled-content>\n g seroconversion, nine patients (50%) had undetectable levels of\n HBV DNA<\/jats:styled-content>\n , and 11 patients (61%) achieved normal alanine aminotransferase (\n ALT<\/jats:styled-content>\n ) levels. The other 18 patients received sequential telbivudine treatment (group\n B<\/jats:styled-content>\n ). After 48\u00a0weeks of treatment, 11 patients (61%) had undergone\n HB<\/jats:styled-content>\n e\n A<\/jats:styled-content>\n g seroconversion, and all patients had undetectable levels of\n HBV DNA<\/jats:styled-content>\n and normal\n ALT<\/jats:styled-content>\n levels. All patients tolerated sequential telbivudine treatment, and only slightly elevated creatine kinase levels were observed. Switching to telbivudine therapy was efficient and safe in\n HB<\/jats:styled-content>\n e\n A<\/jats:styled-content>\n g\u2010positive chronic hepatitis\n B<\/jats:styled-content>\n patients with partial responses to 48\u00a0weeks of pegylated interferon. Sequential treatment with telbivudine resulted in an\n HB<\/jats:styled-content>\n e\n A<\/jats:styled-content>\n g seroconversion rate of 61% and an\n HBV DNA<\/jats:styled-content>\n loss rate of 100% after 48\u00a0weeks. This promising strategy warrants further investigation.\n <\/jats:p>","DOI":"10.1111\/jvh.12064","type":"journal-article","created":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T01:48:12Z","timestamp":1357004892000},"page":"52-57","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy of sequential use of telbivudine in hepatitis\n B<\/scp>\n e antigen\u2010positive chronic hepatitis\n B<\/scp>\n patients with partial responses to pegylated interferon: a pilot study"],"prefix":"10.1111","volume":"20","author":[{"given":"Z.","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"},{"name":"Key Laboratory of Tropical Disease Control (Sun Yat\u2010Sen University) Ministry of Education Guangzhou Guangdong 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"},{"name":"Key Laboratory of Tropical Disease Control (Sun Yat\u2010Sen University) Ministry of Education Guangzhou Guangdong 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"},{"name":"Key Laboratory of Tropical Disease Control (Sun Yat\u2010Sen University) Ministry of Education Guangzhou Guangdong 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"},{"name":"Key Laboratory of Tropical Disease Control (Sun Yat\u2010Sen University) Ministry of Education Guangzhou Guangdong 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"},{"name":"Key Laboratory of Tropical Disease Control (Sun Yat\u2010Sen University) Ministry of Education Guangzhou Guangdong 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"},{"name":"Key Laboratory of Tropical Disease Control (Sun Yat\u2010Sen University) Ministry of Education Guangzhou Guangdong 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"},{"name":"Key Laboratory of Tropical Disease Control (Sun Yat\u2010Sen University) Ministry of Education Guangzhou Guangdong 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23190"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.10.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-008-9080-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22956"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2009.10.012"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01449.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-011-0151-8"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.10.020"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4149\/av_2012_01_31"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-7-207"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/789859"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066422"},{"key":"e_1_2_7_14_1","first-page":"549","article-title":"Preliminary clinical study of efficacy on re\u2010treatment for interferon suboptimal CHB patients","volume":"17","author":"Xue R","year":"2009","journal-title":"Zhonghua Ganzangbing Zazhi"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043470"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(06)80051-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21302"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00997.x"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.12064","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.12064","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.12064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T17:13:01Z","timestamp":1694625181000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.12064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,4]]},"references-count":17,"journal-issue":{"issue":"s1","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1111\/jvh.12064"],"URL":"https:\/\/doi.org\/10.1111\/jvh.12064","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,4]]}}}