{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T13:54:50Z","timestamp":1776693290848,"version":"3.51.2"},"reference-count":36,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T00:00:00Z","timestamp":1362355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Orally administered nucleus(t)ide analogues (<jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>) have brought about a simple, safe and effective therapeutic approach for chronic hepatitis B (<jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content>). However, treatment duration is long and some female patients become pregnant during treatment. In recent years, there have been gradually increasing reports on the safety of telbivudine (<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>d<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>) treatment for chronic hepatitis B virus (<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>) infection in the third trimester of pregnancy to block mother\u2010to\u2010infant transmission (<jats:styled-content style=\"fixed-case\">MTIT<\/jats:styled-content>) of <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>; however, the safety of <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>d<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> treatment for chronic <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> infection for the entire pregnancy has not been reported. The aim of the present study was to evaluate the safety of <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>d<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> treatment for chronic <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> infection for the entire pregnancy and provide a reference for <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010infected fertile women on how to block <jats:styled-content style=\"fixed-case\">MTIT<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>. Eighty\u2010six pregnant women who received <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>d<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> treatment either before or in early pregnancy were enrolled in the study. Adverse events were prospectively observed for the entire pregnancy and perinatal period, and short\u2010term and long\u2010term follow\u2010up of infants was conducted, monitoring the abnormalities of infants and blocking rate of <jats:styled-content style=\"fixed-case\">MTIT<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>d<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> treatment. Eighty\u2010six pregnant women treated with <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>d<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> had a total of 89 pregnancies: 6 (6.7%) had early embryonic death or spontaneous abortion, 1 (1.1%) had ectopic pregnancy and three had a second pregnancy after initial abortion. Fifty\u2010one mothers completed pregnancy: one had induction of labour at 24\u00a0weeks of pregnancy for cleft lip and palate of the foetus and 50 delivered 52 full\u2010term live infants. One infant had right ear accessories, and the total occurrence of congenital abnormality was 3.8%. Thirty\u2010nine infants were followed up for more than 6\u00a0months and completed all examinations for MTIT. None of the infants were HBsAg positive, resulting in a 100% success rate of blocking MTIT. All mothers maintained good liver function during the third trimester of pregnancy; 86% maintained complete virological response (HBV DNA &lt;500\u00a0copies\/mL) prior to delivery, and none developed progression of liver disease. Factors leading to increased adverse effects and drug resistance were not found. LdT treatment is safe and effective in chronic HBV\u2010infected pregnant mothers for the entire pregnancy.<\/jats:p>","DOI":"10.1111\/jvh.12066","type":"journal-article","created":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T06:48:18Z","timestamp":1357022898000},"page":"65-70","source":"Crossref","is-referenced-by-count":41,"title":["Safety of telbivudine treatment for chronic hepatitis B for the entire pregnancy"],"prefix":"10.1111","volume":"20","author":[{"given":"M.","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Beijing Ditan Hospital affiliated to Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Hepatology Beijing Ditan Hospital affiliated to Capital Medical University Beijing 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