{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T08:32:25Z","timestamp":1709022745823},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T00:00:00Z","timestamp":1360108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:label \/><jats:p>To identify complementary laboratory indices for determining the disease status of patients with hepatitis B virus. Subjects were divided into six groups: hepatitis B virus carrier, mild chronic hepatitis B, moderate chronic hepatitis B, severe chronic hepatitis B, fulminant hepatitis B and healthy controls. Serum alanine aminotransferase, total bilirubin and direct bilirubin were measured by an automatic analyser. The levels of T\u2010cell immunoglobulin domain and mucin\u2010domain\u2010containing molecule\u20103, macrophage inflammatory protein 2, neutrophil gelatinase\u2010associated lipocalin and inducible nitric oxide synthase were measured by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>. T\u2010cell immunoglobulin domain, mucin\u2010domain\u2010containing molecule\u20103, macrophage inflammatory protein 2 and inducible nitric oxide synthase levels were significantly higher in patients with severe chronic hepatitis B compared with those in patients with mild and moderate chronic hepatitis B or fulminant hepatitis B (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). When normal or abnormal alanine aminotransferase was present, significant differences between macrophage inflammatory protein 2 and T\u2010cell immunoglobulin domain and mucin\u2010domain\u2010containing molecule\u20103 levels between patients with mild, moderate, severe chronic hepatitis B or fulminant hepatitis B were observed (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). Our results suggest that T\u2010cell immunoglobulin domain and mucin\u2010domain\u2010containing molecule\u20103 and macrophage inflammatory protein 2 could serve as alanine aminotransferase, direct bilirubin or total bilirubin complementary indices for determining the status of patients with hepatitis B.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jvh.12067","type":"journal-article","created":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T09:03:24Z","timestamp":1360141404000},"page":"566-574","source":"Crossref","is-referenced-by-count":2,"title":["Complementary laboratory indices for predicting the disease status of patients with hepatitis <scp>B<\/scp> virus infection"],"prefix":"10.1111","volume":"20","author":[{"given":"F.","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Infectious Disease Diagnosis and Treatment First Affiliated Hospital College of Medicine Zhejiang University Key Laboratory of Infectious Diseases Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine School of Public Health Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Infectious Disease Diagnosis and Treatment First Affiliated Hospital College of Medicine Zhejiang University Key Laboratory of Infectious Diseases Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. H.","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Infectious Disease Diagnosis and Treatment First Affiliated Hospital College of Medicine Zhejiang University Key Laboratory of Infectious Diseases Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. P.","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Infectious Disease Diagnosis and Treatment First Affiliated Hospital College of Medicine Zhejiang University Key Laboratory of Infectious Diseases Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Wang","sequence":"additional","affiliation":[{"name":"Qilu Hospital of Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X. X.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. R.","family":"Zhao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Medical College of Xian Jiaotong University Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. S.","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Infectious Disease Diagnosis and Treatment First Affiliated Hospital College of Medicine Zhejiang University Key Laboratory of Infectious Diseases Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Infectious Disease Diagnosis and Treatment First Affiliated Hospital College of Medicine Zhejiang University Key Laboratory of Infectious Diseases Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200411003-00008"},{"key":"e_1_2_8_3_1","volume-title":"Hepatitis B. (Fact sheet no. 204)","author":"World Health Organization.","year":"2000"},{"issue":"28","key":"e_1_2_8_4_1","first-page":"255","article-title":"Hepatitis B vaccines","volume":"79","author":"World Health Organization","year":"2004","journal-title":"Wkly Epidemiol Rec"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23190"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-122-4-199502150-00001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.05.013"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2004.12.009"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840190629"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60207-5"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-11-240"},{"issue":"1","key":"e_1_2_8_12_1","first-page":"1","article-title":"The guideline of prevention and treatment for chronic hepatitis B. (2010 version)","volume":"12","author":"Chinese Society of Hepatology and Chinese Society of Infectious Diseases, C.M.A","year":"2011","journal-title":"Chin Prev Med"},{"issue":"6","key":"e_1_2_8_13_1","first-page":"324","article-title":"The programme of prevention and cure for viral hepatitis","volume":"8","author":"Chinese Society of Infectious Diseases and Parasitology and Chinese Society of Hepatology of Chinese Medical Association","year":"2000","journal-title":"Zhonghua Gan zangbing Zazhi"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200004273421707"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/46.12.2027"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.36061"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.102996"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-1-200207020-00006"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.044_c.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.52.10.679"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.11.026"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510250214"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/01902149409031733"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2008.11.003"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni988"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-8-113"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.12.005"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.09.121"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.22158"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.10.12"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.259978"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.065987"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.12067","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.12067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.12067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T09:01:09Z","timestamp":1696237269000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.12067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,6]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/jvh.12067"],"URL":"https:\/\/doi.org\/10.1111\/jvh.12067","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,6]]}}}