{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:26:13Z","timestamp":1759177573282},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T00:00:00Z","timestamp":1362441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We aimed to compare the evolution of estimated glomerular filtration rate (<jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">HIV\u2010, HIV\u2013HBV<\/jats:styled-content>\u2010 and <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010infected patients treated with tenofovir disoproxil fumarate (TDF). Three groups of patients receiving <jats:styled-content style=\"fixed-case\">TDF<\/jats:styled-content>\u00a0&gt;\u00a012\u00a0months were recruited: 194 <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients, 85 <jats:styled-content style=\"fixed-case\">HIV\u2013HBV<\/jats:styled-content>\u2010coinfected patients and 50 <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010infected patients. <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> was estimated using the <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>odification of the <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>iet in <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>enal <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>isease (<jats:styled-content style=\"fixed-case\">MDRD<\/jats:styled-content>) equation. Multivariate regression models were constructed to estimate factors associated with <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> decrease from baseline. A total of 329 patients were studied. Median follow\u2010up was 2.7\u00a0years. Median <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> decrease was \u22124.9 (\u221216.6 to +7.2)\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>. After multivariate stepwise regression analysis, age (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0002), non\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>frican origin (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), baseline <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) and <jats:styled-content style=\"fixed-case\">TDF<\/jats:styled-content> duration (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) were associated with <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> decrease in the whole population, while hypertension, diabetes and type of infection were not. Age (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), non\u2010African origin (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0004), baseline <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) and <jats:styled-content style=\"fixed-case\">TDF<\/jats:styled-content> duration (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.007) remained associated with <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> decline in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HIV\u2013HBV<\/jats:styled-content>\u2010infected patients, while other variables including <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> risk factor, <jats:styled-content style=\"fixed-case\">CDC<\/jats:styled-content> stage, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 and <jats:styled-content style=\"fixed-case\">HIV\u2010RNA<\/jats:styled-content> levels were not. Age (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03), non\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>frican origin (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004), baseline <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) and baseline <jats:styled-content style=\"fixed-case\">HBV\u2013DNA\u00a0<\/jats:styled-content>&gt;\u00a02000\u00a0IU\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04) were associated with <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> decline in <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HIV\u2013HBV<\/jats:styled-content>\u2010infected patients, while other variables including HBV risk factor and fibrosis stage were not. Estimated glomerular filtration rate decline under <jats:styled-content style=\"fixed-case\">TDF<\/jats:styled-content> therapy appears mainly associated with older age, non\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>frican origin, higher baseline <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> and longer <jats:styled-content style=\"fixed-case\">TDF<\/jats:styled-content> administration but not with the type of viral infection. Regular follow\u2010up of renal function, especially tubular function is recommended during <jats:styled-content style=\"fixed-case\">TDF<\/jats:styled-content> therapy.<\/jats:p>","DOI":"10.1111\/jvh.12088","type":"journal-article","created":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T13:29:31Z","timestamp":1362490171000},"page":"650-657","source":"Crossref","is-referenced-by-count":10,"title":["Evolution of glomerular filtration rate in <scp>HIV<\/scp>\u2010infected, <scp>HIV<\/scp>\u2013<scp>HBV<\/scp>\u2010coinfected and <scp>HBV<\/scp>\u2010infected patients receiving tenofovir disoproxil fumarate"],"prefix":"10.1111","volume":"20","author":[{"given":"P.","family":"Pradat","sequence":"first","affiliation":[{"name":"Hospices Civils de Lyon H\u00f4pital de la Croix\u2010Rousse Service d'H\u00e9patologie Lyon France"},{"name":"INSERM U1052 Lyon France"},{"name":"Universit\u00e9 Lyon 1 Lyon 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