{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T07:59:23Z","timestamp":1722931163209},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,9,15]],"date-time":"2013-09-15T00:00:00Z","timestamp":1379203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Agenzia Italiana del Farmaco"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We assessed, in real\u2010life practice, viral, demographic, genetic and metabolic factors influencing the sustained virologic response (SVR), with a gender\u2010oriented analysis, in patients with chronic hepatitis C virus (HCV) treated with pegylated interferon and ribavirin. Six hundred and seventy na\u00efve patients were treated with dual therapy and evaluated by gender and HCV genotype. Associations between baseline variables and SVR were assessed by multivariate logistic regression analysis. Among 362 genotype 1 patients, SVR was achieved in 158 patients (44%), and SVR was independently associated with age less than 50\u00a0years (OR 2.12; 95% CI 1.09\u20134.30; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.039) and C\/C genotype <jats:italic>rs12979860 SNP<\/jats:italic> (OR 2.83; 1.19\u20136.74; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.002) in 163 females, while absence of visceral obesity (OR 2.491; 1.131\u20135.487; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.023), HCV\u2010RNA lower than 400\u00a0000\u00a0IU\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> (OR 2.66; 1.273\u20135.558; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.009) and C\/C genotype <jats:italic>rs12979860 SNP<\/jats:italic> (OR 4.969; 2.401\u201310.283; <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001) were independently associated with SVR in 199 males. Combining favourable baseline variables, the probability of obtaining SVR ranged from 27.6% to 84.2% in females, and from 14.3% to 85.7% in males. The rate of SVR was 81.1% in 175 genotype 2 patients, and 69% in 100 genotype 3 patients. Rapid virologic response was the only valid predictor of SVR regardless of other features. In conclusions, in the setting of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> genotype 1, chronic hepatitis, combining rapid virologic response and predictive factors, which are different for females and males, allows clinicians to single out a group of patients whose likelihood of <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> exceeds 80%. For these patients, triple therapy with first\u2010generation protease inhibitors may be unwarranted.<\/jats:p>","DOI":"10.1111\/jvh.12106","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T08:46:46Z","timestamp":1444726006000},"page":"790-800","source":"Crossref","is-referenced-by-count":11,"title":["Who is more likely to respond to dual treatment with pegylated\u2010interferon and ribavirin for chronic hepatitis C? A gender\u2010oriented analysis"],"prefix":"10.1111","volume":"20","author":[{"given":"V.","family":"Di Marco","sequence":"first","affiliation":[{"name":"Sezione di Gastroenterologia &amp; Epatologia Dipartimento Biomedico di Medicina Interna e Specialistica Universit\u00e0 di Palermo Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Covolo","sequence":"additional","affiliation":[{"name":"Istituto di Igiene Epidemiologia e Sanit\u00e0 Pubblica Universit\u00e0 di Brescia Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Calvaruso","sequence":"additional","affiliation":[{"name":"Sezione di Gastroenterologia &amp; Epatologia Dipartimento Biomedico di Medicina Interna e Specialistica Universit\u00e0 di Palermo Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Levrero","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Interna e Specialit\u00e0 Mediche \u2013 DMISM and the Sapienza Life Nanoscience Laboratory (SLN\u2010Lab) Sapienza Universita' di Roma Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Puoti","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Complessa di Malattie Infettive Azienda Ospedaliera Niguarda C\u00e0 Granda Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Suter","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Complessa di Malattie Infettive Ospedali Riuniti di Bergamo Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. B.","family":"Gaeta","sequence":"additional","affiliation":[{"name":"Cattedra di Malattie Infettive Dipartimento Medico\u2010Chirurgico di Internistica Clinica e Sperimentale Seconda Universit\u00e0 di Napoli Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Malattie Infettive ed Epatologia Azienda Ospedaliero\u2010Universitaria di Parma Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Raimondo","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Epatologia Clinica e Molecolare Dipartimento di Medicina Interna Universit\u00e0 di Messina Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Fattovich","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Complessa di Gastroenterologia ed Endoscopia Digestiva Dipartimento di Medicina Azienda Ospedaliera 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