{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:06:56Z","timestamp":1791216416865,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T00:00:00Z","timestamp":1370995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National 12th 5-year Plan for Hepatitis Research","award":["2012ZX10002004-011"],"award-info":[{"award-number":["2012ZX10002004-011"]}]},{"name":"Tianjin Science and Technology Fund","award":["12JCYBJC17300"],"award-info":[{"award-number":["12JCYBJC17300"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Summary Acute\u2010on\u2010chronic liver failure(<jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content>) is an increasingly recognized entity encompassing an acute deterioration of liver function and results in the failure of one or more organs with high short\u2010term mortality. The focus of this study was to discover noninvasive and reliable biomarkers for the diagnosis and prognosis of hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010related <jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content>. Ultra\u2010performance liquid chromatography\u2013mass spectrometry (<jats:styled-content style=\"fixed-case\">UPLC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>) was used to analyse serum metabolites of 28 patients with hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010related <jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content>, 35 patients with <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hild\u2010<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ugh A cirrhosis, 30 patients with chronic hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> and 35 healthy volunteers (<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>). Characteristic metabolites were screened, identified and dynamically tracked to investigate their value for diagnosis and prognosis. After comparing serum metabolic profile of hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010related <jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hild\u2010<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ugh A cirrhosis, 99 characteristic metabolites were selected, and 38 of them were identified. Dynamic tracking model demonstrated that 17 metabolites were related to prognosis of hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010related <jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content>, and there were also 11 metabolites which improved with treatment in the survival group. The correlations between these characteristic metabolites and the model for end\u2010stage liver disease score were strong. These observations contributed to the investigation of the mechanisms of hepatitis B\u2010related <jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content> manifestation and progression on the metabolic level, and they provided information for the identification of biomarkers for the diagnosis and prognosis of hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010related <jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jvh.12122","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T03:02:55Z","timestamp":1371092575000},"page":"53-63","source":"Crossref","is-referenced-by-count":25,"title":["Cross\u2010sectional and dynamic change of serum metabolite profiling for <scp>H<\/scp>epatitis <scp>B<\/scp>\u2010related acute\u2010on\u2010chronic liver failure by <scp>UPLC<\/scp>\/<scp>MS<\/scp>"],"prefix":"10.1111","volume":"21","author":[{"given":"C. Y.","family":"Nie","sequence":"first","affiliation":[{"name":"The Third Central Clinical College of Tianjin Medical University Tianjin China"},{"name":"Department of Hepatology Tianjin Third Central Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Hepatology Tianjin Third Central Hospital Tianjin China"},{"name":"Tianjin Institute of Hepatobiliary Disease Tianjin China"},{"name":"Tianjin Key Laboratory of Artificial Cells Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Tianjin Third Central Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Li","sequence":"additional","affiliation":[{"name":"The Third Central Clinical College of Tianjin Medical University Tianjin China"},{"name":"Department of Hepatology Tianjin Third Central Hospital Tianjin China"},{"name":"Tianjin Institute of Hepatobiliary Disease Tianjin China"},{"name":"Tianjin Key Laboratory of Artificial Cells Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hepatology Tianjin Third Central Hospital Tianjin China"},{"name":"Tianjin Institute of Hepatobiliary Disease Tianjin China"},{"name":"Tianjin Key Laboratory of Artificial Cells Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. X.","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Hepatology Tianjin Third Central Hospital Tianjin China"},{"name":"Tianjin Institute of Hepatobiliary Disease Tianjin China"},{"name":"Tianjin Key Laboratory of Artificial Cells Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatology Tianjin Third Central Hospital Tianjin China"},{"name":"Tianjin Institute of Hepatobiliary Disease Tianjin China"},{"name":"Tianjin Key Laboratory of Artificial Cells Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Tianjin Third Central Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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