{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:40:39Z","timestamp":1791276039318,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Hepatitis <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) infection is associated with insulin resistance (<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>), although mechanisms leading to <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> in these patients are not completely understood. The aim of this study was to evaluate the association of <jats:italic>interleukin 28B<\/jats:italic> (<jats:italic>IL28B)<\/jats:italic> and interleukin 28 receptor alpha (<jats:italic>IL28RA<\/jats:italic>) polymorphisms with <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> among human immunodeficiency virus (HIV)\/HCV\u2010coinfected patients. We carried out a cross\u2010sectional study on 203 patients. <jats:italic>IL28B<\/jats:italic> (rs8099917) and <jats:italic>IL28RA (<\/jats:italic>rs10903035) polymorphisms were genotyped by GoldenGate<jats:sup>\u00ae<\/jats:sup> assay. IR was defined as homeostatic model assessment (<jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>) values \u22653.00. Univariate and multivariate generalized linear models (GLM) were used to compare <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content> values and the percentage of patients with IR according to <jats:italic>IL28B<\/jats:italic> and <jats:italic>IL28RA<\/jats:italic> genotypes. In total, 32% (<jats:italic>n<\/jats:italic>\u00a0=\u00a065\/203) of the patients had IR. <jats:italic>IL28B<\/jats:italic> rs8099917 TT was not significantly associated with <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content> values and <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>. In contrast, rs10903035 <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> was significantly associated with high <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content> values taking into account all patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.024), as well as the subgroups of patients with significant fibrosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.047) and infected with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> genotype 3 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.024). Additionally, rs10903035 AA was significantly associated with <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content> \u22653.00) in all patients (adjusted odds ratio (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>)\u00a0=\u00a02.02; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.034), in patients with significant fibrosis (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>\u00a0=\u00a02.86; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.039) and HCV genotype 3 patients (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>\u00a0=\u00a04.89; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.031). In conclusions, <jats:italic>IL28RA<\/jats:italic> polymorphism (rs10903035) seems to be implicated in the glucose homeostasis because AA genotype increases the likelihood of <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>, but this association was different depending on hepatic fibrosis and <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> genotype.<\/jats:p>","DOI":"10.1111\/jvh.12130","type":"journal-article","created":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T09:20:53Z","timestamp":1374052853000},"page":"189-197","source":"Crossref","is-referenced-by-count":7,"title":["<i><scp>IL<\/scp>28<scp>RA<\/scp><\/i> polymorphism (rs10903035) is associated with insulin resistance in <scp>HIV<\/scp>\/<scp>HCV<\/scp>\u2010coinfected patients"],"prefix":"10.1111","volume":"21","author":[{"given":"M. A.","family":"Jim\u00e9nez\u2010Sousa","sequence":"first","affiliation":[{"name":"Unit of Viral Infection and Immunity National Centre of Microbiology, Instituto de Salud Carlos III Majadahonda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Berenguer","sequence":"additional","affiliation":[{"name":"Infectious Diseases\u2010HIV Unit Hospital General Universitario \u201cGregorio Mara\u00f1\u00f3n\u201d Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Fern\u00e1ndez\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Unit of Viral Infection and Immunity National Centre of Microbiology, Instituto de Salud Carlos III Majadahonda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Micheloud","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Hospital General Universitario \u201cGregorio Mara\u00f1\u00f3n\u201d Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Guzm\u00e1n\u2010Fulgencio","sequence":"additional","affiliation":[{"name":"Unit of Viral Infection and Immunity National Centre of Microbiology, Instituto de Salud Carlos III Majadahonda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Miralles","sequence":"additional","affiliation":[{"name":"Infectious Diseases\u2010HIV Unit Hospital General Universitario \u201cGregorio Mara\u00f1\u00f3n\u201d Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Pineda\u2010Tenor","sequence":"additional","affiliation":[{"name":"Unit of Viral Infection and Immunity National Centre of Microbiology, Instituto de Salud Carlos III Majadahonda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Garc\u00eda\u2013\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Unit of Viral Infection and Immunity National Centre of Microbiology, Instituto de Salud Carlos III Majadahonda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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