{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T08:55:44Z","timestamp":1771577744894,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Summary<\/jats:title>No data exist to assess certain polymorphisms that have a potential effect on the immune response in patients with chronic hepatitis delta (CHD<\/jats:styled-content>). The aim of this study was to investigate polymorphisms in 6 polymorphic sites: IL<\/jats:styled-content>\u201010 \u20101082 (rs1800896), IL<\/jats:styled-content>\u201010 \u2010627 (rs1800872), IFN<\/jats:styled-content>\u2010\u03b3 +874 (rs62559044), TNF<\/jats:styled-content>\u2010\u03b1 \u2010308 (rs1800629), vitamin D receptor (VDR<\/jats:styled-content>) Fok<\/jats:italic>I (rs2228570) and VDR <\/jats:styled-content>Taq<\/jats:italic>I (rs731236). The genotypes of 67 patients with CHD<\/jats:styled-content> and 119 patients with chronic hepatitis B (CHB<\/jats:styled-content>) were compared. In addition, 56 individuals with resolved hepatitis B virus (HBV<\/jats:styled-content>) infection were used as a control group for patients with CHB<\/jats:styled-content>. Polymorphisms in TNF<\/jats:styled-content>\u2010\u03b1, IL<\/jats:styled-content>\u201010, and VDR<\/jats:styled-content> genes were analysed using polymerase chain reaction\/restriction fragment length polymorphism methods. The IFN<\/jats:styled-content>\u2010\u03b3 gene polymorphism was detected by allele\u2010specific polymerase chain reaction (PCR<\/jats:styled-content>). Patients with CDH<\/jats:styled-content> were more likely to have advanced liver disease compared with patients with CHB<\/jats:styled-content> (P<\/jats:italic>\u00a0<\u00a00.0001). IL<\/jats:styled-content>\u201010 \u20101082 and VDR <\/jats:styled-content>Taq<\/jats:italic>I polymorphisms showed significant differences between patients with CHD<\/jats:styled-content> and CHB<\/jats:styled-content>. The high secretory IL<\/jats:styled-content>\u201010 \u20101082 genotype GG<\/jats:styled-content> was less frequent in CHD<\/jats:styled-content> compared with patients with CHB<\/jats:styled-content> and resolved HBV<\/jats:styled-content> (17.7%, 37.4% and 47.1%, respectively (P<\/jats:italic>\u00a0<\u00a00.05 for CHD <\/jats:styled-content>vs <\/jats:italic>CHB<\/jats:styled-content> and resolved HBV<\/jats:styled-content>). The frequency of the high secretory VDR <\/jats:styled-content>Taq<\/jats:italic>I TT<\/jats:styled-content> genotype was 86.6% in patients with CHD<\/jats:styled-content>, 62.7% in patients with CHB<\/jats:styled-content> and 62.5% in resolved HBV<\/jats:styled-content> individuals (CHD <\/jats:styled-content>vs <\/jats:italic>CHB<\/jats:styled-content>: P<\/jats:italic>\u00a0<\u00a00.05). None of the polymorphisms analysed had an effect on HBV<\/jats:styled-content> persistence. IL<\/jats:styled-content>\u201010 \u20101082 and VDR <\/jats:styled-content>Taq<\/jats:italic>I polymorphisms may contribute to the more severe liver disease associated with CHD<\/jats:styled-content> compared with CHB<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jvh.12139","type":"journal-article","created":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T03:10:48Z","timestamp":1374549048000},"page":"297-304","source":"Crossref","is-referenced-by-count":11,"title":["Tumour necrosis factor\u2010alpha, interleukin\u201010, interferon\u2010gamma and vitamin D<\/scp> receptor gene polymorphisms in patients with chronic hepatitis delta"],"prefix":"10.1111","volume":"21","author":[{"given":"S. C.","family":"Karatayli","sequence":"first","affiliation":[{"name":"Hepatology Institute Ankara University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z. 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