{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T04:47:55Z","timestamp":1771649275841,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T00:00:00Z","timestamp":1377648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["81072766"],"award-info":[{"award-number":["81072766"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Beijing Technology Discipline Project","award":["Z111107056811044"],"award-info":[{"award-number":["Z111107056811044"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Acute\u2010on\u2010chronic hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> liver failure (<jats:styled-content style=\"fixed-case\">ACHBLF<\/jats:styled-content>) has a poor prognosis in patients with hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> virus infection. The role of the neutrophil\u2013lymphocyte ratio (<jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content>), which reflects the inflammatory status of the patient before treatment, has never been studied in this setting. To investigate the predictive value of <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">ACHBLF<\/jats:styled-content>, a retrospective cohort with 216 patients and a prospective validation cohort with 73 patients were recruited. Multivariate analyses showed that total bilirubin (<jats:styled-content style=\"fixed-case\">TBIL<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content>, age and model for end\u2010stage liver disease (<jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content>) score had prognostic significance for survival. Both <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> (0.781) and <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content> score (0.744) had higher <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curves, which differed significantly from those for age (0.615) and <jats:styled-content style=\"fixed-case\">TBIL<\/jats:styled-content> (0.691), but not from each other (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.94). <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> \u22642.36 predicted lower mortality (with 91.6% sensitivity and 86.0% negative predictive value), and <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> &gt;6.12 was a warning sign for higher mortality risk (with 90.1% specificity and 80.3% positive predictive value). These results demonstrated that pretreatment <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> was associated with the prognosis of patients with <jats:styled-content style=\"fixed-case\">ACHBLF<\/jats:styled-content>, and elevated <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> predicted poor outcome within 8\u00a0weeks. We suggest that <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> cut\u2010offs of \u22642.36 and &gt;6.12 are powerful markers for predicting mortality in <jats:styled-content style=\"fixed-case\">ACHBLF<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jvh.12160","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T01:18:40Z","timestamp":1377739120000},"page":"499-507","source":"Crossref","is-referenced-by-count":74,"title":["Neutrophil\u2013lymphocyte ratio: a novel predictor for short\u2010term prognosis in acute\u2010on\u2010chronic hepatitis <scp>B<\/scp> liver failure"],"prefix":"10.1111","volume":"21","author":[{"given":"H.","family":"Liu","sequence":"first","affiliation":[{"name":"Beijing Ditan Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Ditan Hospital Capital Medical University Beijing China"},{"name":"Peking University People's Hospital Peking University Hepatology Institute Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Wan","sequence":"additional","affiliation":[{"name":"Beijing Ditan Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Sang","sequence":"additional","affiliation":[{"name":"Beijing Ditan Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Chang","sequence":"additional","affiliation":[{"name":"Beijing Ditan Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Ditan Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Zeng","sequence":"additional","affiliation":[{"name":"Beijing Ditan Hospital Capital Medical University Beijing China"},{"name":"Institute of Infectious Diseases Capital Medical University Beijing China"},{"name":"Beijing Key Laboratory of Emerging Infectious Diseases Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-008-9106-x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0b013e328344b42d"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030322"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.11.008"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e3181e6bf13"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2008.01046.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2011.00911.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2009.01242.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2004-0009OC"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901309"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040639"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-11-4390"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/he.2000.5852"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06910.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-011-1192-x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-7682-5-2"},{"issue":"1","key":"e_1_2_8_18_1","first-page":"5","article-title":"Ratio of neutrophil to lymphocyte counts\u2013rapid and simple parameter of systemic inflammation and stress in critically ill","volume":"102","author":"Zahorec R","year":"2001","journal-title":"Bratisl Lek Listy"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000331494"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2010.11.006"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2506"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57990"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0310162"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181faefa3"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2011.01475.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02262.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000232940"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.06.040"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25801"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-008-9098-6"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.2310\/JIM.0b013e3181db8764"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-011-9333-5"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23273"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.10.019"},{"issue":"115","key":"e_1_2_8_35_1","first-page":"814","article-title":"Changes in peripheral T\u2010lymphocyte subsets in acute\u2010on\u2010chronic liver failure patients with artificial liver support system","volume":"59","author":"Lou YF","year":"2012","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181624464"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.12160","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.12160","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.12160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:28:29Z","timestamp":1695540509000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.12160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,28]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/jvh.12160"],"URL":"https:\/\/doi.org\/10.1111\/jvh.12160","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,28]]}}}