{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:50:11Z","timestamp":1788871811073,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T00:00:00Z","timestamp":1387324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"crossref","award":["2010-0001200"],"award-info":[{"award-number":["2010-0001200"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2014,12]]},"abstract":"Summary<\/jats:title>\n \n Previous studies have demonstrated that the treatment of chronic hepatitis\n B<\/jats:styled-content>\n (\n CHB<\/jats:styled-content>\n ) infection with adefovir (\n ADV<\/jats:styled-content>\n ) can impair renal function. In contrast, treatment with telbivudine (LdT) improves renal function in\n CHB<\/jats:styled-content>\n patients. The aim of this study was to evaluate the renoprotective effect of LdT in\n CHB<\/jats:styled-content>\n patients receiving\n ADV<\/jats:styled-content>\n \u2010based combination therapy. The effects of treatment with\n ADV<\/jats:styled-content>\n + LdT on renal function were compared to those resulting from treatment with ADV + entecavir (\n ETV<\/jats:styled-content>\n ),\n ADV<\/jats:styled-content>\n + lamivudine (\n LAM<\/jats:styled-content>\n ),\n ADV<\/jats:styled-content>\n alone and ETV alone. The consecutive cohort analysis included 831 CHB patients who received\n ADV<\/jats:styled-content>\n + LdT,\n ADV<\/jats:styled-content>\n +\n LAM<\/jats:styled-content>\n ,\n ADV<\/jats:styled-content>\n +\n ETV<\/jats:styled-content>\n ,\n ADV<\/jats:styled-content>\n alone or ETV alone for 96\u00a0weeks. Alterations in estimated glomerular filtration rate (e\n GFR<\/jats:styled-content>\n ) were compared between the five groups using a linear mixed\u2010effects model.\n HBV DNA<\/jats:styled-content>\n levels were also compared between the five groups during the 96\u2010week period. Among the five treatment groups, significant improvements in e\n GFR<\/jats:styled-content>\n were observed in the\n ADV<\/jats:styled-content>\n + LdT and\n ADV<\/jats:styled-content>\n +\n LAM<\/jats:styled-content>\n groups over time (\n P\u00a0<\/jats:italic>\n <\u00a00.001 for each group compared with baseline e\n GFR<\/jats:styled-content>\n ). In patients with a baseline e\n GFR<\/jats:styled-content>\n between 50 and 90\u00a0mL\/min, the change in e\n GFR<\/jats:styled-content>\n was the most significant in the\n ADV<\/jats:styled-content>\n + LdT group (+0.641\u00a0mL\/min;\n P\u00a0<\/jats:italic>\n <\u00a00.001). Age, gender, baseline e\n GFR<\/jats:styled-content>\n and treatment option were significant predictive factors for e\n GFR<\/jats:styled-content>\n changes. In conclusion, our results suggest that the combination therapy of LdT and\n ADV<\/jats:styled-content>\n is significantly associated with renoprotective effects in\n CHB<\/jats:styled-content>\n patients when compared with other\n ADV<\/jats:styled-content>\n \u2010based combination or single therapies.\n <\/jats:p>","DOI":"10.1111\/jvh.12217","type":"journal-article","created":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T22:56:39Z","timestamp":1387407399000},"page":"873-881","source":"Crossref","is-referenced-by-count":22,"title":["Telbivudine protects renal function in patients with chronic hepatitis\n B<\/scp>\n infection in conjunction with adefovir\u2010based combination therapy"],"prefix":"10.1111","volume":"21","author":[{"given":"M.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Seoul Metropolitan Government Seoul National University Boramae Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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