{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:05Z","timestamp":1790532005344,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T00:00:00Z","timestamp":1390953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CDC Foundation","award":["MOA 481-13"],"award-info":[{"award-number":["MOA 481-13"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2014,12]]},"abstract":"Summary<\/jats:title>\n \n Assessment of liver fibrosis is critical for successful individualized disease management in persons with chronic hepatitis\n B<\/jats:styled-content>\n (\n CHB<\/jats:styled-content>\n ) or chronic hepatitis\n C<\/jats:styled-content>\n (\n CHC<\/jats:styled-content>\n ). We expanded and validated serum marker indices to provide accurate, reproducible and easily applied methods of fibrosis assessment. Liver biopsy results from over 284\n CHB<\/jats:styled-content>\n and 2304\n CHC<\/jats:styled-content>\n patients in the\n C<\/jats:styled-content>\n hronic\n H<\/jats:styled-content>\n epatitis\n C<\/jats:styled-content>\n ohort\n S<\/jats:styled-content>\n tudy (\u2018\n CH<\/jats:styled-content>\n e\n CS<\/jats:styled-content>\n ') were mapped to a F0\u2013F4 equivalent scale.\n APRI<\/jats:styled-content>\n and\n FIB<\/jats:styled-content>\n \u20104 scores within a 6\u2010month window of biopsy were mapped to the same scale. A novel algorithm was applied to derive and validate optimal cut\u2010offs for differentiating fibrosis levels. For the prediction of advanced fibrosis and cirrhosis, the\n FIB<\/jats:styled-content>\n \u20104 score outperformed the other serum marker indices in the\n CHC<\/jats:styled-content>\n cohort and was similar to\n APRI<\/jats:styled-content>\n in the\n CHB<\/jats:styled-content>\n cohort. The area under the receiver operating characteristic curves (\n AUROC<\/jats:styled-content>\n ) for\n FIB<\/jats:styled-content>\n \u20104 in differentiating F3\u2013F4 from F0\u2013F2 was 0.86 (95%\n CI<\/jats:styled-content>\n : 0.80\u20130.92) for\n CHB<\/jats:styled-content>\n and 0.83 (95%\n CI<\/jats:styled-content>\n : 0.81\u20130.85) for\n CHC<\/jats:styled-content>\n . The suggested cut\u2010offs based on\n FIB<\/jats:styled-content>\n \u20104 model produced high positive predictive values [\n CHB<\/jats:styled-content>\n : 90.0% for F0\u2013F2, 100.0% for cirrhosis (F4);\n CHC<\/jats:styled-content>\n : 89.7% for F0\u2013F2; 82.9% for cirrhosis (F4)]. In this large observational cohort,\n FIB<\/jats:styled-content>\n \u20104 predicted the upper and lower end of liver fibrosis stage (cirrhosis and F0\u2013F2, respectively) with a high degree of accuracy in both\n CHB<\/jats:styled-content>\n and\n CHC<\/jats:styled-content>\n patients.\n <\/jats:p>","DOI":"10.1111\/jvh.12224","type":"journal-article","created":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T02:45:25Z","timestamp":1390963525000},"page":"930-937","source":"Crossref","is-referenced-by-count":98,"title":["The validity of serum markers for fibrosis staging in chronic hepatitis B and C"],"prefix":"10.1111","volume":"21","author":[{"given":"J.","family":"Li","sequence":"first","affiliation":[{"name":"Henry Ford Health System Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. C.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Henry Ford Health System Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. B.","family":"Rupp","sequence":"additional","affiliation":[{"name":"Henry Ford Health System Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henry Ford Health System Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Boscarino","sequence":"additional","affiliation":[{"name":"Center for Health Research Geisinger Clinic Danville PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Vijayadeva","sequence":"additional","affiliation":[{"name":"The Center for Health Research Kaiser Permanente Hawaii Honolulu HI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"The Center for Health Research Kaiser Permanente Northwest Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lu","sequence":"additional","affiliation":[{"name":"Henry Ford Health System Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Chronic Hepatitis Cohort Study (CHeCS) Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-11-91"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.02.017"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02663.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit245"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22085"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2009.02192.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50346"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200607000-00013"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21835"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24105"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)31836-8"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21178"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.10.044"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21669"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-84858-7"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1586\/erp.10.93"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis815"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4044"},{"issue":"9","key":"e_1_2_9_21_1","first-page":"3","article-title":"Fibroscan (transient elastography) for the measurement of liver fibrosis","volume":"8","author":"Afdhal NH","year":"2012","journal-title":"Gastroenterol Hepatol"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.06038.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hep.2003.09.022"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.12224","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.12224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.12224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T09:04:08Z","timestamp":1695459848000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.12224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,29]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/jvh.12224"],"URL":"https:\/\/doi.org\/10.1111\/jvh.12224","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,29]]}}}