{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:22:55Z","timestamp":1740126175063,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T00:00:00Z","timestamp":1392249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81201277","81271833","81071354"],"award-info":[{"award-number":["81201277","81271833","81071354"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of China","doi-asserted-by":"crossref","award":["20120071120099"],"award-info":[{"award-number":["20120071120099"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guanghui","award":["GH-2011-201"],"award-info":[{"award-number":["GH-2011-201"]}]},{"name":"Shanghai Medical College"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Chronic hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> therapy with nucleos(t)ide analogues, particularly tenofovir or adefovir, may affect renal function. To date, there has not been a head\u2010to\u2010head controlled study to assess estimated glomerular filtration rate (<jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>) fluctuations in nucleos(t)ide\u2010treated <jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content> patients. We aimed to evaluate the long\u2010term effects of nucleos(t)ide on <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> in Chinese patients with chronic hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>. This prospective cohort study included 275 patients. Patient subgroups included those treated with lamivudine (<jats:italic>n<\/jats:italic>\u00a0=\u00a050), adefovir (<jats:italic>n<\/jats:italic>\u00a0=\u00a060), telbivudine (<jats:italic>n<\/jats:italic>\u00a0=\u00a068) and entecavir (<jats:italic>n<\/jats:italic>\u00a0=\u00a061); untreated patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a036) served as control. After an average follow\u2010up duration of 23\u00a0months, <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> calculated by <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ockcroft\u2013<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ault and <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>odification of <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>iet in <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>enal <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>isease formulas increased by 18.35\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/min and 19.34\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/min (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001) in the telbivudine group, respectively, and decreased by 10.95\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/min and 12.17\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/min (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0001) in the adefovir group, respectively. Even if renal function was normal or mildly impaired at baseline, <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> increased significantly more in the telbivudine group than in the other groups (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). More patients in the adefovir group (23%) had a \u226520% decrease in <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> than the other groups (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001). More patients in the telbivudine group (31%) had a \u226520% increase in <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> than the other groups (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001). In conclusion, prolonged telbivudine therapy resulted in improved <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>, while adefovir therapy was associated with decreased <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>. Lamivudine and entecavir therapy did not significantly influence <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jvh.12229","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T02:38:09Z","timestamp":1392604689000},"page":"46-54","source":"Crossref","is-referenced-by-count":23,"title":["Impact of nucleos(t)ide analogues on the estimated glomerular filtration rate in patients with chronic hepatitis <scp>B<\/scp>: a prospective cohort study in <scp>C<\/scp>hina"],"prefix":"10.1111","volume":"22","author":[{"given":"X.","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Huashan Hospital Fudan University Shanghai China"},{"name":"Key laboratory of Medical Molecular Virology of the Ministries of Education and Health (MOH&amp;MOE) Fudan University Shanghai China"},{"name":"Department of Hepatitis Diseases Shanghai Public Health Clinical Center Fudan University Shanghai 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