{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:22:40Z","timestamp":1740126160368,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"name":"The China National S&T Major Project for Infectious Diseases","award":["2012ZX10002003 and 2012ZX10002005"],"award-info":[{"award-number":["2012ZX10002003 and 2012ZX10002005"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81271826"],"award-info":[{"award-number":["81271826"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Acute hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) infection is primarily followed by chronic infection, while spontaneous recovery of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection (<jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) occurs in a minority of those infected. Identification of <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> clinically depends on two combined indicators, persistently undetectable peripheral <jats:styled-content style=\"fixed-case\">HCV RNA<\/jats:styled-content> and positivity for anti\u2010<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>. However, the characteristics of dynamic variation in anti\u2010<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> antibodies in <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>, especially in those patients co\u2010infected with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>, are still undefined. In this study, a cohort of patients infected with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> through commercial blood collection practices was studied. We found that the annual decreasing rate of anti\u2010<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> presented a gradually accelerated process in <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> resolvers. However, the variation in the decline of anti\u2010<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> presented a slowly accelerated process within the early decrease stage and a gradually decelerated process within the latter decrease stage. In addition, we deduced that it expended approximately 16\u00a0years from natural <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> recovery to undetectable peripheral anti\u2010<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> resolvers co\u2010infected with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>, while this time was estimated to be 20\u00a0years in <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> without <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> co\u2010infection. Our data indicated that the decay of anti\u2010<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> was accelerated by <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010related impairment of immune function. The prevalence of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection may be severely underestimated in this large\u2010scale retrospective epidemiologic investigation in an <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected population.<\/jats:p>","DOI":"10.1111\/jvh.12238","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T12:24:10Z","timestamp":1392207850000},"page":"690-695","source":"Crossref","is-referenced-by-count":1,"title":["<scp>HIV<\/scp> co\u2010infection accelerates decay of humoral responses in spontaneous resolvers of <scp>HCV<\/scp> infection"],"prefix":"10.1111","volume":"21","author":[{"given":"Y.","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Microbiology Peking University Health Science Center Beijing China"},{"name":"Department of Nutrition and Food Hygiene College of Public Health Zhengzhou University Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Microbiology Peking University Health Science Center Beijing China"},{"name":"Center of Infectious Diseases Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Microbiology Peking University Health Science Center Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Microbiology Peking University Health Science Center Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Microbiology Peking University Health Science Center Beijing China"},{"name":"Center of Infectious Diseases Peking University Beijing 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