{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:11:10Z","timestamp":1783012270141,"version":"3.54.6"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,3,26]],"date-time":"2014-03-26T00:00:00Z","timestamp":1395792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To examine the associations between maternal hepatitis B (<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>) and hepatitis C (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) infection status and selected infant neurological outcomes diagnosed at birth, we conducted a population\u2010based, retrospective cohort study on singleton live births in Florida from 1998 to 2009. Primary exposures included maternal <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> monoinfection. The neurological outcomes included brachial plexus injury, cephalhematoma, foetal distress, feeding difficulties, intraventricular h aemorrhage and neonatal seizures. Multivariable logistic regression models were used to generate odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) and 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) that were adjusted for socio\u2010demographic characteristics, risky behaviours, pregnancy complications and pre\u2010existing medical conditions, and timing of delivery. The risk of an adverse neurological outcome was higher in infants born to mothers with hepatitis viral infection (7.2% for <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>, 5.0% for <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>), compared with infants of hepatitis virus\u2010free mothers (4.2%). After adjusting for potential confounders, women with <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> were twice as likely to have infants who suffered from brachial plexus injury (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.04, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.15\u20133.60), while those with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> had an elevated odds of having an infant with feeding difficulties (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.32, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.06\u20131.64) and a borderline increased likelihood for neonatal seizures (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.74, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a00.98\u20133.10). Additionally, <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>+ mothers had a 22% increased odds of having an infant with some type of adverse neurological outcome (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.22, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.03\u20131.44). Our findings add to current understanding of the association between maternal <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infections and infant neurological outcomes. Further research evaluating the role of maternal <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infections (including viraemia, treatment) on pregnancy outcomes is warranted.<\/jats:p>","DOI":"10.1111\/jvh.12250","type":"journal-article","created":{"date-parts":[[2014,3,26]],"date-time":"2014-03-26T09:02:45Z","timestamp":1395824565000},"source":"Crossref","is-referenced-by-count":43,"title":["Maternal hepatitis <scp>B<\/scp> and hepatitis <scp>C<\/scp> infection and neonatal neurological outcomes"],"prefix":"10.1111","volume":"21","author":[{"given":"J. L.","family":"Salemi","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics College of Public Health University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. E.","family":"Whiteman","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology College of Medicine University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. M.","family":"August","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics College of Public Health University of South Florida Tampa FL USA"},{"name":"Department of Community and Family Health College of Public Health University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Chandler","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics College of Public Health University of South Florida Tampa FL USA"},{"name":"Department of Community and Family Health College of Public Health University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. K.","family":"Mbah","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics College of Public Health University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. M.","family":"Salihu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics College of Public Health University of South Florida Tampa FL USA"},{"name":"Division of Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology College of Medicine University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2008.01933.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1446.2009.00790.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2008.01947.x"},{"issue":"1","key":"e_1_2_8_5_1","first-page":"S131","article-title":"Hepatitis and reproduction","volume":"86","author":"Practice Committee of the American Society for Reproductive Medicine","year":"2006","journal-title":"Fertil 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