{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:53:30Z","timestamp":1790146410509,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T00:00:00Z","timestamp":1406678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"French Agence Nationale de Recherche sur le Sida et les h\u00e9patites virales","award":["ANRS 12184"],"award-info":[{"award-number":["ANRS 12184"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>gypt, as elsewhere, liver biopsy (<jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content>) remains the gold standard to assess liver fibrosis in chronic hepatitis <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>) and is required to decide whether a treatment should be proposed. Many of its disadvantages have led to develop noninvasive methods to replace <jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content>. These new methods should be evaluated in <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>gypt, where circulating virus genotype 4 (<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4), increased body mass index and co\u2010infection with schistosomiasis may interfere with liver fibrosis assessment. <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>gyptian <jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>\u2010infected patients with <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4 underwent a <jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content>, an elastometry measurement (<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ibroscan<jats:sup>\u00a9<\/jats:sup>), and serum markers (<jats:styled-content style=\"fixed-case\">APRI<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> F<\/jats:styled-content>ib4 and <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ibrotest<jats:sup>\u00a9<\/jats:sup>). Patients had to have a <jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content> \u226515\u00a0mm length or \u226510 portal tracts with two pathologists blinded readings to be included in the analysis. Patients with hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> virus co\u2010infection were excluded. Three hundred and twelve patients are reported. The performance of each technique for distinguishing <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>0<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>1 <jats:italic>vs<\/jats:italic> <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>2<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>4 was compared. The area under receiver operating characteristic curves was 0.70, 0.76, 0.71 and 0.75 for <jats:styled-content style=\"fixed-case\">APRI<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> F<\/jats:styled-content>ib\u20104, <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ibrotest\u00a9 and <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ibroscan\u00a9, respectively (no influence of schistosomiasis was noticed). An algorithm using the <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ib4 for identifying patients with <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>2 stage or more reduced by nearly 90% the number of liver biopsies. Our results demonstrated that noninvasive techniques were feasible in <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>gypt, for <jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content> G4\u2010infected patients. Because of its validity and its easiness to perform, we believe that <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ib4 may be used to assess the <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>2 threshold, which decides whether treatment should be proposed or delayed.<\/jats:p>","DOI":"10.1111\/jvh.12285","type":"journal-article","created":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T05:19:19Z","timestamp":1406697559000},"page":"245-253","source":"Crossref","is-referenced-by-count":37,"title":["Comparison of liver biopsy and noninvasive techniques for liver fibrosis assessment in patients infected with <scp>HCV<\/scp>\u2010genotype 4 in <scp>E<\/scp>gypt"],"prefix":"10.1111","volume":"22","author":[{"given":"P.","family":"Bonnard","sequence":"first","affiliation":[{"name":"Infectious Diseases H\u00f4pital Tenon (AP\u2010HP) Paris France"},{"name":"Unit\u00e9 INSERM U707 UPMC Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Elsharkawy","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine and Hepatology Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Zalata","sequence":"additional","affiliation":[{"name":"Department of Pathology Mansoura Faculty of Medicine Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Delarocque\u2010Astagneau","sequence":"additional","affiliation":[{"name":"Emerging Diseases Epidemiology Unit Institut Pasteur Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Biard","sequence":"additional","affiliation":[{"name":"Emerging Diseases Epidemiology Unit Institut Pasteur Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Le Fouler","sequence":"additional","affiliation":[{"name":"Emerging Diseases Epidemiology Unit Institut Pasteur Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. B.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine and Hepatology Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Abdel\u2010Hamid","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Faculty of Medicine Minia University Minia Egypt"},{"name":"Viral Hepatitis Research Laboratory National Hepatology and Tropical Medicine Research Institute Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"El\u2010Daly","sequence":"additional","affiliation":[{"name":"Viral Hepatitis Research Laboratory National Hepatology and Tropical Medicine Research Institute Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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