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This study was therefore to identify the potential role of <jats:italic>SOCS1<\/jats:italic> and its promoter methylation pattern in ACHBLF patients. Sixty ACHBLF patients, 60 chronic hepatitis B (CHB) patients and 30 healthy controls were investigated in this study. We found that expression of <jats:italic>SOCS1 <\/jats:italic><jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> in CHB and ACHBLF patients was significantly higher than that in healthy controls. The serum level of IL\u20106, IFN\u2010<jats:italic>\u03b3<\/jats:italic> and TNF\u2010<jats:italic>\u03b1<\/jats:italic> was significantly higher in ACHBLF than CHB. Increased serum level of IL\u20106, IFN\u2010<jats:italic>\u03b3<\/jats:italic> and TNF\u2010<jats:italic>\u03b1<\/jats:italic> was correlated with total bilirubin, ALT, PTA and MELD scores in ACHBLF. The degree of methylation of the <jats:italic>SOCS1<\/jats:italic> in ACHBLF patients (35.0%, 21\/60) was significantly higher than that in CHB patients (16.7%, 10\/60). Furthermore, methylated group showed lower level of <jats:italic>SOCS1,<\/jats:italic> and higher MELD scores and mortality rate when compared with unmethylated group of ACHBLF. These results suggested that <jats:italic>SOCS1<\/jats:italic> might contribute to immune\u2010related liver damage in ACHBLF, and its aberrant methylation may be a key event for the prognosis of ACHBLF.<\/jats:p>","DOI":"10.1111\/jvh.12286","type":"journal-article","created":{"date-parts":[[2014,7,21]],"date-time":"2014-07-21T08:10:39Z","timestamp":1405930239000},"page":"307-317","source":"Crossref","is-referenced-by-count":5,"title":["Methylation of suppressor of cytokine signalling 1 gene promoter is associated with acute\u2010on\u2010chronic hepatitis <scp>B<\/scp> liver failure"],"prefix":"10.1111","volume":"22","author":[{"given":"J.\u2010J.","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hepatology Qilu Hospital of Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.\u2010C.","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Hepatology Qilu Hospital of Shandong University Jinan 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