{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:18:59Z","timestamp":1765700339097},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,7,24]],"date-time":"2014-07-24T00:00:00Z","timestamp":1406160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010infected patients, the vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> deficiency has been related to chronic liver diseases, progression of hepatic fibrosis and poor response to the treatment. The <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>27B1 gene, which encodes the 1\u2010<jats:italic>\u03b1<\/jats:italic>\u2010hidroxylase and involved in the 1,25\u2010dihydroxyvitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> synthesis, was recently associated to type\u20101 diabetes, autoimmune disorders and treatment response in <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>. Then, we aimed to investigate the role of <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>27B1 polymorphisms in <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> treatment with <jats:styled-content style=\"fixed-case\">PEG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>. We retrospectively enrolled 190 patients with chronic hepatitis <jats:styled-content style=\"fixed-case\">B HB<\/jats:styled-content>eAg negative treated for 48\u00a0weeks with <jats:styled-content style=\"fixed-case\">PEG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IFN <\/jats:styled-content><jats:italic>\u03b1<\/jats:italic>\u20102a. We examined the role of rs4646536 <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>27<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>1 <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>27<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>1+2838) according to virological and serological response. Our results showed that the <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> genotype of <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>27<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>1+2838 was significantly prevalent in patients with end\u2010of\u2010therapy virological response (37.6%) <jats:italic>vs <\/jats:italic><jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> (9.4%) (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). Virological relapse was prevalent in patients with <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> genotype (12.6%) <jats:italic>vs <\/jats:italic><jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> genotype (2.1%) (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> genotype was also related to <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg loss (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.004) and anti\u2010<jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>s appearance (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.002). In the multivariate analysis, the <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> genotype resulted to be a good positive predictor of sustained virological response (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a05.632, <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>\u00a0=\u00a01.938\u201316.368, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.001) and serological response (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a06.161, <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>\u00a0=\u00a01.856\u201320.457, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.003). The <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>27B1+2838 polymorphism may be useful as pretreatment factor to selection of patients with higher probability of response to therapy.<\/jats:p>","DOI":"10.1111\/jvh.12288","type":"journal-article","created":{"date-parts":[[2014,7,24]],"date-time":"2014-07-24T08:42:51Z","timestamp":1406191371000},"page":"318-327","source":"Crossref","is-referenced-by-count":25,"title":["Role of <scp>CYP<\/scp>27<scp>B<\/scp>1+2838 promoter polymorphism in the treatment of chronic hepatitis <scp>B HB<\/scp>e<scp>A<\/scp>g negative with <scp>PEG<\/scp>\u2010interferon"],"prefix":"10.1111","volume":"22","author":[{"given":"L.","family":"Boglione","sequence":"first","affiliation":[{"name":"Unit of Infectious Diseases Department of Medical Sciences Amedeo di Savoia Hospital University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Cusato","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Department of Medical Sciences Amedeo di Savoia Hospital University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"De Nicol\u00f2","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Department of Medical Sciences Amedeo di Savoia Hospital University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Cariti","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Department of Medical Sciences Amedeo di Savoia Hospital University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Di Perri","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Department of Medical Sciences Amedeo di Savoia Hospital University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"D'Avolio","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Department of Medical Sciences Amedeo di Savoia Hospital University of Turin Turin 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