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To evaluate the relationship between depression and <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>, among other factors, in an <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010infected cohort. In this cross\u2010sectional analysis, seventy\u2010four non\u2010type 2 diabetic, noncirrhotic, <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010infected patients underwent comprehensive clinical, histologic and metabolic evaluation. <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> was assessed directly with an insulin suppression test by measuring steady\u2010state plasma glucose (<jats:styled-content style=\"fixed-case\">SSPG<\/jats:styled-content>) levels during continuous infusions of octreotide, glucose and insulin. Logistic regression modelling was used to evaluate predictors associated with depression. Thirty\u2010nine (53%) patients were depressed, and 21 (54%) depressed patients were on at least one antidepressant. A higher estimated proportion of depressed patients were <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>aucasian (51% <jats:italic>vs<\/jats:italic> 20%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005), unemployed (69% <jats:italic>vs<\/jats:italic> 49%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.07), heavier smokers (18 pack\u2010years <jats:italic>vs<\/jats:italic> 13 pack\u2010years, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.07), on substance abuse therapy (16% <jats:italic>vs<\/jats:italic> 3%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.06) and had lower <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> levels (1.2\u00a0mmol\/L <jats:italic>vs<\/jats:italic> 1.4\u00a0mmol\/L, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). The mean <jats:styled-content style=\"fixed-case\">SSPG<\/jats:styled-content> levels in depressed and nondepressed patients were 7.3 and 8.3\u00a0mmol\/L (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.45), respectively. In multipredictor adjusted analysis, only <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>aucasian race (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.19, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.42\u201312.35, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009) and lower <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.95, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.89\u20130.99, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.046) were associated with depression. In conclusion, although prevalent, depression was not associated with peripheral <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> in this <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010infected cohort. Attention to other modifiable factors associated with depression in the <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010infected population is warranted.<\/jats:p>","DOI":"10.1111\/jvh.12306","type":"journal-article","created":{"date-parts":[[2014,9,8]],"date-time":"2014-09-08T07:05:39Z","timestamp":1410159939000},"page":"272-280","source":"Crossref","is-referenced-by-count":2,"title":["Depression is not associated with peripheral insulin resistance in patients with chronic hepatitis <scp>C<\/scp> infection"],"prefix":"10.1111","volume":"22","author":[{"given":"S. C.","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Medicine San Francisco General Hospital University of California San Francisco San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kornak","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of California San Francisco San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Khalili","sequence":"additional","affiliation":[{"name":"Department of Medicine San Francisco General Hospital University of California San Francisco San Francisco CA USA"},{"name":"Liver Center San Francisco General Hospital University of California San Francisco San Francisco CA 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