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At present, seven drugs, including two interferons and five oral nucleos(t)ide analogues (<jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>s), have been approved for the treatment of chronic hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>. Interferon works by immunomodulation, but is successful in less than a third of treated patients and is a relatively weak antiviral. <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>s directly suppress the hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> virus but have limited durability. Based on current data, combination of <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content> and interferon results in greater viral suppression but does not translate to off\u2010treatment sustained response. Concomitant or sequential treatment also does not make a difference. Combining telbivudine and interferon also runs the risk of severe peripheral neuropathy. On the other hand, interferon switch or additional therapy in patients well controlled with <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>s appears to improve the durability of off\u2010treatment response. This article reviews current data on interferon and <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content> combination and discusses potential future developments.<\/jats:p>","DOI":"10.1111\/jvh.12341","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T09:30:47Z","timestamp":1416216647000},"page":"825-834","source":"Crossref","is-referenced-by-count":37,"title":["Combination therapy of interferon and nucleotide\/nucleoside analogues for chronic hepatitis <scp>B<\/scp>"],"prefix":"10.1111","volume":"21","author":[{"given":"G. 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