{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:49:59Z","timestamp":1792457399346,"version":"4.5.0"},"reference-count":8,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T00:00:00Z","timestamp":1418342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Congenital cytomegalovirus (c<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>) infection can reside in many organ systems; however, the virus has a particular predilection towards inhabiting the reticuloendothelial system, especially the liver. Specific studies focusing only on hepatic involvement in infants with c<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> are lacking. We report our experience with a large cohort of infants treated in our hospital clinic due to c<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> and hepatic involvement. Hepatic involvement was defined either as hepatitis (elevated alanine transaminases (ALT) &gt;80\u00a0units\/L without cholestatic disease) or cholestatic disease (elevated ALT &gt;80\u00a0units\/L combined with direct bilirubin &gt;2\u00a0mg\/dL). During the study period, 198 infants were diagnosed with symptomatic c<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> in our clinic. Hepatic involvement was observed in 13 infants (6.6%); 7 (3.5%) with hepatitis and 6 (3%) with cholestatic disease. Maternal primary infection with cytomegalovirus during pregnancy was diagnosed in 7 (53.8%) of the 13 infants, nonprimary in 3 (23.1%) and unknown in 3 (23.1%). Among these 13 infants, central nervous system (<jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>) involvement was observed in 11 (84.6%) and hearing impairment in 7 (53.8%). Treatment with an antiviral agent was initiated in all cases. Gradual improvement of hepatic enzymes and cholestasis was observed over a prolonged period. We found that the incidence of hepatic involvement in infants with c<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> is much less frequent than previously reported. The hepatic involvement in these infants may manifest in two different ways, and thus, a high index of suspicion and a stepwise approach will help in correctly diagnosing these infants. Antiviral treatment due to <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> involvement is warranted and prognosis is excellent.<\/jats:p>","DOI":"10.1111\/jvh.12374","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T06:30:12Z","timestamp":1418365812000},"page":"763-768","source":"Crossref","is-referenced-by-count":28,"title":["Hepatic involvement in congenital cytomegalovirus infection \u2013 infrequent yet significant"],"prefix":"10.1111","volume":"22","author":[{"given":"E.","family":"Bilavsky","sequence":"first","affiliation":[{"name":"Department of Pediatrics C Schneider Children's Medical Center Petah Tiqva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Department of Pediatric Radiology Schneider Children's Medical Center Petah Tiqva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Bar\u2010Sever","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Division of Nuclear Medicine Schneider Children's Medical Center Petah Tiqva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Pardo","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Department of Gynecology and Obstetrics Rabin Medical Center Beilinson Hospital Petah Tiqva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Amir","sequence":"additional","affiliation":[{"name":"Department of Pediatrics C Schneider Children's Medical Center Petah Tiqva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit629"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.12.007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199202000-00007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-010-1176-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(03)00192-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-008-0774-2"},{"key":"e_1_2_8_8_1","first-page":"942","article-title":"Infantile cholestasis due to cytomegalovirus infection of the liver. A possible cause of paucity of interlobular bile ducts","volume":"117","author":"Kage M","year":"1993","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_8_9_1","unstructured":"http:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT00466817?term=congenital+cmv&rank=9(accessed 28 April 2014)."}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.12374","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.12374","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.12374","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T08:33:11Z","timestamp":1696235591000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.12374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,12]]},"references-count":8,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/jvh.12374"],"URL":"https:\/\/doi.org\/10.1111\/jvh.12374","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,12]]}}}