{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:26:38Z","timestamp":1787243198147,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T00:00:00Z","timestamp":1424908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Indian Council of Medical Research (ICMR), New Delhi"},{"name":"University Grants Commission (UGC), New Delhi"},{"name":"Council of Scientific & Industrial Research (CSIR), New Delhi"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2015,10]]},"abstract":"Summary<\/jats:title>\n \n Effective recognition of viral infection and successive activation of antiviral innate immune responses are vital for host antiviral defence, which largely depends on multiple regulators, including Toll\u2010like receptors (\n TLR<\/jats:styled-content>\n s) and micro\n RNA<\/jats:styled-content>\n s. Several early reports suggest that specific\n TLR<\/jats:styled-content>\n \u2010mediated immune responses can control hepatitis\n B<\/jats:styled-content>\n virus (\n HBV<\/jats:styled-content>\n ) replication and express differentially with disease outcome. Considering the versatile function of miR\u2010155 in the\n TLR<\/jats:styled-content>\n \u2010mediated innate immune response, we aimed to study the association between miR\u2010155 and\n TLR<\/jats:styled-content>\n s and their subsequent impact on\n HBV<\/jats:styled-content>\n replication using both a\n HBV<\/jats:styled-content>\n \u2010replicating stable cell line (HepG2.2.15) and\n HBV<\/jats:styled-content>\n \u2010infected liver biopsy and serum samples. Our results showed that miR\u2010155 was suppressed during\n HBV<\/jats:styled-content>\n infection and a subsequent positive correlation of miR\u2010155 with\n TLR<\/jats:styled-content>\n 7 activation was noted. Further, ectopic expression of miR\u2010155\n in vitro<\/jats:italic>\n reduced\n HBV<\/jats:styled-content>\n load as evidenced from reduced viral\n DNA<\/jats:styled-content>\n ,\n mRNA<\/jats:styled-content>\n and subsequently reduced level of secreted viral antigens (\n HB<\/jats:styled-content>\n sAg and\n HB<\/jats:styled-content>\n eAg). Our results further suggested that\n CCAAT<\/jats:styled-content>\n \/enhancer\u2010binding protein\u2010\n \u03b2<\/jats:italic>\n (C\/\n EBP<\/jats:styled-content>\n \u2010\n \u03b2<\/jats:italic>\n ), a positive regulator of\n HBV<\/jats:styled-content>\n transcription, was inhibited by miR\u2010155. Taken together, our study established a correlation between miR\u2010155 and\n TLR<\/jats:styled-content>\n 7 during\n HBV<\/jats:styled-content>\n infection and also demonstrated\n in vitro<\/jats:italic>\n that increased miR\u2010155 level could help to reduce\n HBV<\/jats:styled-content>\n viral load by targeting C\/\n EBP<\/jats:styled-content>\n \u2010\n \u03b2<\/jats:italic>\n .\n <\/jats:p>","DOI":"10.1111\/jvh.12390","type":"journal-article","created":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T04:57:19Z","timestamp":1424926639000},"page":"817-827","source":"Crossref","is-referenced-by-count":46,"title":["Expression of microRNA\u2010155 correlates positively with the expression of Toll\u2010like receptor 7 and modulates hepatitis B virus via C\/EBP\u2010\n \u03b2<\/i>\n in hepatocytes"],"prefix":"10.1111","volume":"22","author":[{"given":"N.","family":"Sarkar","sequence":"first","affiliation":[{"name":"ICMR Virus Unit Kolkata, ID & BG Hospital Campus Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Panigrahi","sequence":"additional","affiliation":[{"name":"ICMR Virus Unit Kolkata, ID & BG Hospital Campus Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pal","sequence":"additional","affiliation":[{"name":"ICMR Virus Unit Kolkata, ID & BG Hospital Campus Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Biswas","sequence":"additional","affiliation":[{"name":"ICMR Virus Unit Kolkata, ID & BG Hospital Campus Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. P.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology SCB Medical College Cuttack India"},{"name":"Kalinga Gastroenterology Foundation Beam Diagnostics Premises Cuttack India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. K.","family":"Kar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology SCB Medical College Cuttack India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bandopadhyay","sequence":"additional","affiliation":[{"name":"ICMR Virus Unit Kolkata, ID & BG Hospital Campus Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Das","sequence":"additional","affiliation":[{"name":"ICMR Virus Unit Kolkata, ID & BG Hospital Campus Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Saha","sequence":"additional","affiliation":[{"name":"ICMR Virus Unit Kolkata, ID & BG Hospital Campus Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kanda","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Oncology Chiba University, Graduate School of Medicine Chiba 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